Inclusion Of Acetonitrile Research Articles

Repetitive‐Synthesis of Bulky Dendrimers – A Reversibly Photoactive Dendrimer with Six Azobenzene Side Chains

AbstractDendrimers with bulky repeating units containing up to 43 benzene rings (in 9) have been obtained by using a repetitive divergent synthetic strategy (three generations). The new functional dendrimer 13 containing six azobenzene units at the periphery was synthesized allowing a reversible switching of the shape and size of the molecule upon irradiation. An X‐ray structure analysis of the dendritic molecule 3a shows the inclusion of acetonitrile.

Inclusion of acetonitrile in a macrobicyclic host molecule

The first inclusion complex of acetonitrile in a molecular cavity is described; X-ray structure and IR spectra show that the π-donor host 4 encloses acetonitrile as a π-accepto selectively inside its molecular cavity, whereas empty intermolecular cavities are not occupied by acetonitrile.

Orientational selectivity for the inclusion of acetonitrile in tailor-made macrobicyclic host molecules

The first σ–π-interaction between a C–H acidic acetonitrile methyl group and and a ‘π–basic’ host cavity is described based on the X-ray structure of the complex between the host 3 and MeCN; comparison with the structure of the complex between 1 and MeCN shows orientational selectivity for MeCN in the two hosts.

High-performance hydrophobic-interaction chromatography of steroid hormone receptors

The use of high-performance hydrophobic-interaction chromatography (HPHIC) on SynChropak 500 propyl columns has been evaluated for the first time in the analysis of estrogen receptors labeled with [ 1 2 5I]iodoestradiol-17β. These receptors were extracted from reproductive tissues with 500 m M phosphate buffer and applied to the stationary phase. Utilizing an inverse phosphate gradient (500 to 10 m M, elution resulted in rapidly excluded components in the void volume followed by a second radioactive peak at 400 m M phosphate. Both peaks appeared to contain specific estrogen-binding components in that steroid association was inhibited by diethylstilbestrol and free ligand was eluted with a different retention time. A great deal of [ 1 2 5 I]iodoestradiol- 17β was retained by the column. Inclusion of acetonitrile (20%) in the mobile phase resulted in the elution of[ 1 2 5I]iodoestradiol-receptor complexes at a different position from free ligand. Distribution of specific estrogen-binding components appeared to be tumor-dependent. These preliminary results indicate that HPHIC may be useful for isolating various isoforms of steroid hormone receptors so that detailed information regarding their intrinsic properties may be ascertained.