Incidence Of Diabetes Mellitus Research Articles

Association of Renal Hyperfiltration with Incidence of New-Onset Diabetes Mellitus: A Nationwide Cohort Study.

Background and Objectives: While the connection between decreased kidney function and diabetes mellitus (DM) is commonly acknowledged, there is insufficient research examining the relationship between higher-than-normal estimated glomerular filtration rate (eGFR) and the incidence risk of new-onset DM. Our research aimed to explore the relationship between an eGFR and the incidence risk of new-onset DM in the Korean general population through a nationwide longitudinal study. Methods: This research employed the cohort records of the National Health Insurance Service in Korea, analyzing records from 2,294,358 individuals between the ages of 20 and 79 who underwent health check-ups between 2010 and 2011. The eGFR levels from the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation were used to assess the renal function. New-onset DM was defined as two or more claims with the International Classification of Diseases-10 classification codes E10 to E14, being prescribed any medication for lowering blood glucose, or having a record of fasting plasma glucose levels of ≥126 mg/dL from a health examination after the index date. Results: The mean age of subjects was 47.34 ± 13.76 years. The 150,813 (6.57%) new-onset DM cases were identified over a median follow-up of 9.63 years. In the multivariable Cox regression analysis, in comparison with the 5th decile, the 10th (≥114.12 mL/min/1.73 m2) (hazard ratio (HR): 0.52, 95% confidence interval (CI) (0.50-0.54), p < 0.001) eGFR decile was significantly associated with a decreased incidence of new-onset DM. Moreover, eGFR >120 mL/min/1.73 m2 was associated with a reduced risk of new-onset DM (HR: 0.40, 95% CI (0.39-0.42), p < 0.001). These results were consistent regardless of the presence of impaired glucose tolerance, age, or obesity. Conclusion: Our study showed higher-than-normal eGFR levels were associated with a lower risk of incidence for new-onset DM regardless of the presence of impaired glucose tolerance, age, or obesity. In general population, higher-than-normal eGFR may be associated with a lower risk of incidence of new-onset DM.

Early education on diabetes mellitus for the community

Diabetes mellitus is a chronic disease that is increasing around the world, including in Indonesia. Early introduction and education about diabetes mellitus are critical to raising public awareness and understanding of this disease and how to prevent and manage it. This community service program aims to provide education about diabetes mellitus to the community, with a focus on symptom recognition, risk factors, prevention, and disease management. The methods used include counseling, workshops, and the distribution of educational materials. The results of this program are expected to increase public knowledge and awareness about diabetes mellitus so that they can take preventive steps and improve the quality of life of people with diabetes. This educational program is expected to contribute to reducing the incidence of diabetes mellitus and enhancing the community's quality of life

Trends in the Incidence of Gestational Diabetes Mellitus Among the Medicaid Population Before and During the COVID-19 Pandemic.

Importance: Although there are many regional and national studies on the trends in the incidence of gestational diabetes mellitus (GDM), the trends in the incidence of GDM among the Medicaid population are lacking, especially before and during coronavirus disease of 2019 (COVID-19). Objective: To investigate the trends in the incidence of GDM before and during COVID-19 pandemic (2016-2021) among the Louisiana Medicaid population. Design, Setting, and Participants: This study included 111,936, Louisiana Medicaid pregnant women of age 18-50 between January 1, 2016, to December 31, 2021. Main Outcomes and Measures: Pregnancies, GDM, and pre-pregnancy diabetes cases were identified by using the Tenth Revisions of the International Classification of Disease code. The annual incidence of GDM and annual prevalence of pre-pregnancy diabetes were calculated for each age and race subgroup. Results: The age-standardized incidence of GDM increased from 10.2% in 2016 to 14.8 in 2020 and decreased to 14.0% in 2021. The age-standardized prevalence of pre-pregnancy diabetes increased from 2.8% in 2016 to 3.4% in 2018 and decreased to 2.3% in 2021. The age-standardized rate of GDM was the highest among Asian women (23.0%), then White women (15.5%), and African American women (13.9%) (p for difference <0.001). The COVID-19 pandemic saw an increase in the incidence of GDM, with a rise in prominent GDM risk factors, such as obesity and sedentary behaviors, suggesting an association. Conclusion and Relevance: The incidence of GDM significantly increased during the COVID-19 pandemic. Potential reasons might include increased sedentary behavior and increased prevalence of obesity. GDM is a major public health issue, and the prevention of GDM is particularly essential for the Louisiana Medicaid population owing to the high prevalence of GDM-related risk factors in this population.

54225 Elevated circulating blood eosinophils and inflammatory laboratory markers as predictors of incident diabetes mellitus in patients with atopic dermatitis: a multicenter cohort study

54225 Elevated circulating blood eosinophils and inflammatory laboratory markers as predictors of incident diabetes mellitus in patients with atopic dermatitis: a multicenter cohort study

The association between the Helicobacter pylori infection and the occurrence of gestational diabetes: a systematic review and meta-analysis

BackgroundThis meta-analysis aims to establish a more precise association between gestational diabetes mellitus (GDM) incidence and H. pylori infection by amalgamating findings from prior case–control and cohort studies.MethodsTo identify relevant studies, we conducted a comprehensive search using the Excerpta Medica Database (Embase), PubMed (Medline), Web of Science (ISI), and Scopus from January 1990 to November 2022. The screening process involved reviewing the entire text, abstracts, and titles of retrieved articles. Subsequently, data extraction was performed from the selected articles, and their quality was assessed using the Newcastle–Ottawa Scale checklist. Version 17 of STATA software was utilized for the analysis, with relative risks (RR) calculated along with their 95% confidence intervals (CI) to quantify the impact of the included studies.ResultsThis meta-analysis included eight observational and analytical studies. The combined risk of gestational diabetes mellitus (GDM) in pregnant women with H. pylori infection was found to be 1.97 times higher compared to pregnant women without infection (RR: 1.97; 95% CI 1.57–2.47; I2 = 0.00%; P = 0.84).ConclusionPregnant women with H. pylori infection are at an increased risk of developing gestational diabetes.

Impact of iron overload on incidence of diabetes mellitus, cardiac disease, and death in congenital hemolytic anemias

AbstractIron overload and its complications are recognized to be morbid and fatal in patients with congenital hemolytic anemias. In patients with iron overload caused by congenital hemolytic anemias, there has been no study evaluating the dose-response relationship between serum markers of iron overload and long-term health complications. Filling this critical gap was the aim of this study. We evaluated outcomes in a 5-hospital observational cohort study of adults with congenital hemolytic anemias diagnosed with iron overload over a 40-year period and assessed associations between depth and duration of iron overload, as well as clinical complications including diabetes, heart disease, malignancy, bone density disorders, and death. One hundred seventy patients with congenital hemolytic anemias developing iron overload were included. More years experienced of ferritin >500 ng/mL and >1000 ng/mL were associated with the development of diabetes mellitus, with adjusted odds ratios (ORs) of 2.61 per 10-year increment (P = .034) and 3.24 per 10-year increment (P = .035), respectively. More years experienced of ferritin >1000 ng/mL were associated with the development of heart disease (adjusted OR, 5.30 per 10-year increment; P = .002). Peak lifetime ferritin of >10 000 ng/mL was associated with sixfold odds of developing diabetes (P = .04) and 10-fold odds of developing heart disease (P = .007). A peak ferritin >10 000 ng/mL was associated with an increase in mortality (adjusted OR, 6.77; P = .033). In conclusion, iron overload in patients with congenital hemolytic anemias is associated with diabetes mellitus, cardiac disease, and death. Prolonged exposure to relatively modest iron overload was associated with nearly threefold increased odds of diabetes.

Hyperglycemia adversely affects critical physiological events related to rat sperm capacitation

Hyperglycemia, the hallmark of diabetes mellitus (DM), is the main cause of DM-related systemic complications, including reproductive issues. Furthermore, the incidence of DM in males of reproductive ages is becoming an increasing concern, as the complexity of sperm capacitation (an essential process for fertilizing the egg) extends beyond conventional sperm parameters such as count, viability, and motility. Capacitation defects cause male infertility, and DM-related hyperglycemia may affect this process. We explore the effects of uncontrolled hyperglycemia on sperm using alloxan-induced hyperglycemic Wistar rats. In addition to assessing conventional sperm parameters, we also evaluated functional indicators, including hyperactivation (HA) with a pharmacological approach and assessed its effects with a computer-assisted sperm analysis (CASA); fluorescence indicators to monitor membrane potential (EmR, DiSC3(5)) and mitochondrial membrane potential (Ψ, JC-1); CatSper activity, using its ability to permeate Na+ ions, and ATP levels with the luciferin-luciferase reaction. We confirmed previous findings with our hyperglycemic model, which replicated the typical reduction on conventional sperm parameters. In sperm from hyperglycemic rats, we observed increased motility and HA levels after pharmacological treatment. Additionally, CatSper activity was unaffected by hyperglycemia, while EmR was hyperpolarized under non-capacitating condition. Finally, we noted a low percentage of hyperpolarized Ψ and reduced ATP content. This study highlights the significance of impact of hyperglycemia on sperm physiology and capacitation. We proposed that low ATP levels perturb energy state, signaling pathways, ion channels activity, motility, and HA. Our findings offer insight into DM-associated infertility and potential treatment strategies.

EFFECTIVENESS OF WEST SUMATRAN DADIAH ON REDUCING HYPERGLYCAEMIA AND LIPID PROFILE IN DIABETIC RATS

The high incidence of DM (Diabetes Mellitus) has made diabetes a global health problem that is often associated with other health problems and high treatment costs. For this reason, complementary therapies such as Dadiah are needed. Dadiah is fermented buffalo milk from West Sumatra. This study aims to determine the effectiveness of Dadiah on reducing hyperglycaemia and lipid profile of diabetic model rats. The experimental study used 25 rats divided into five groups. Group 1 was negative control, group 2 was positive control, group 3 was DM rats with Dadiah intervention at a dose of 3g/300gBB, group 4 was DM with metformin 13.5mg/kgBB, and group 5 was DM with a combination of Dadiah and Metformin. After STZ induction, each group was given the intervention for six weeks, and the blood sugar and cholesterol levels were observed. The average decrease in blood sugar levels and cholesterol levels close to the negative control group was obtained in the Dadiah and metformin combination treatment group (P3) with an average blood sugar level of 124.2 mg/dL, total cholesterol level of 78.4 mg/dL, HDL level of 28.2 mg/dL, LDL level of 27.8 mg/dL and triglycerides 113.6 mg/dL. The administration of Dadiah and the combination of Dadiah with Metformin proved to have the highest effectiveness in alleviating hyperglycaemia and hypercholesterolemia in diabetes mellitus model rats.

Effect of baseline LH/FSH ratio in PCOS on IVF-ET outcomes: a retrospective cohort study

Objective: To exlplore the association between the baseline luteinizing hormone/follicle stimulating hormone (LH/FSH) ratio of polycystic ovary syndrome (PCOS) and in vitro fertilisation-embryo transfer outcomes. Methods: This was a retrospective cohort study. A total of 2 868 PCOS patients were enrolled, all of the participants were patients in The First Affiliated Hospital of Anhui Medical University Hospital from October 2015 to October 2021. Propensity score matching (1∶2.5) was conducted to regulate the non-random allocation of patients. Data were extracted from the hospital's medical records. Patients with baseline LH/FSH ratio>2 were deemed as study group, patients with baseline LH/FSH ratio≤2 were deemed as control group. Single factor analysis was applied to compare the differences of pregnancy outcomes between two groups. Results: After propensity score matching (1∶2.5), there were no statistically significant differences in baseline data between the two groups (all P>0.05), indicating that the data were comparable. In the study group, the total dose of gonadotropin (Gn) and duration of Gn were lower than those of the control group (t=4.989, P<0.001; t=3.267, P=0.001), the rate of in vitro maturation was higher than that of the control group (χ2=4.938, P=0.026), the number of retrieved oocytes and cleavage were higher than those of the control group (t=-2.305, P=0.021; t=-2.816, P=0.005), but there were no differences in the number and rate of high-quality embryos between the two groups (t=-1.636, P=0.102; t=-0.123, P=0.902). The incidence of moderate to severe ovarian hyperstimulation syndrome in the study group was significantly higher than that in the control group (χ2=17.277, P<0.001). Regardless of fresh embryo transfer or frozen-thawed embryo transfer cycles, the incidences of gestational diabetes mellitus in the study group were higher than those in the control group (χ2=9.174, P=0.002; χ2=4.204, P=0.040) of singleton pregnancy. In the fresh embryo transfer cycle, the clinical pregnancy rate [30.30% (20/66) vs 47.75% (53/111)] and delivery rate [30.30% (20/66) vs 46.85% (52/111)] in the study group were lower than those in the control group (χ2=5.198, P=0.023; χ2=4.695, P=0.030). In the frozen-thawed embryo transfer cycle, the delivery rate in the study group was higer than that in the control group [59.41% (423/712) vs 55.04% (1 053/1 913); χ2=7.526, P=0.023]. The clinical pregnancy rate and delivery rate of fresh embryo transfer cycle in the study group were significantly lower than those of frozen-thawed embryo transfer cycle (χ2=21.308, P<0.001; χ2=20.871, P<0.001), but there were no significant differences in the control group (all P>0.05). Conclusions: PCOS patients with a higher basal LH/FSH ratio are more likely to develop moderate to severe ovarian hyperstimulation syndrome after controlled ovarian stimulation and have a higher incidence of gestational diabetes mellitus. Better pregnancy outcome could be obtained by frozen-thawed embryo transfer.

Trimethylamine N-oxide: A new target for the prevention and treatment of ischemic stroke

At present, ischemic stroke (IS) is the main contributor to mortality and disability. As a major chronic non-communicable disease, it poses a major threat to public health. Adding to the already substantial burden of stroke in China is the rapidly aging population and the rising incidence of diabetes mellitus, hypertension, and hyperlipidemia. As a Chinese proverb goes, &amp;ldquo;diseases invade the body through the mouth,&amp;rdquo; which is, coincidentally, consistent with a claim by Hippocrates, the father of modern medicine, that the source of all diseases begins in the intestines. These ancient wisdom underscore the importance of dissecting the relationship between IS and diet. Food is the primary source of trimethylamine N-oxide (TMAO), an intestinal metabolite, which has drawn a lot of attention because it plays a key role in a number of pathways linked to the development and progression of atherosclerosis. These pathways include lipid metabolism, vascular endothelial injury, and the induction of inflammation. Given its potential as a therapeutic target for IS, conducting in-depth research on TMAO has become particularly crucial. With varied involvement in atherosclerosis, TMAO stands out as a viable target for innovative treatment techniques targeted at decreasing the risk and severity of IS. It is evident that practicing a specific diet can reduce the risk for IS, underscoring the necessity to investigate the role of controlling dietary TMAO intake in mitigating the risk of IS. At present, a growing body of research has explored the role of TMAO in vascular diseases, uncovering numerous interventions to reduce TMAO levels, which serve dual benefits of addressing both atherosclerosis and the associated risk of IS. This paper reviews the relationship between TMAO and IS, along with the progress in research on the clinical value of TMAO, offering new perspectives on IS prevention and treatment.

The Prevalence and Management of Diabetes Mellitus Among Educated and Uneducated Populations in Pakistan. A comparative study

Background: Diabetes mellitus (DM) is a growing public health challenge globally, particularly in developing countries like Pakistan. Education plays a crucial role in DM management and awareness. Objective: The aim of this work was to compare the rate and the treatment of diabetes mellitus (DM) in educated and uneducated people of Pakistan. Methodology: This comparative study was conducted on 500 participants out of which 300 has been given formal education that is at least secondary education whereas 200 has no formal education that is they have dropped out at least at primary level. Diabetes prevalence, awareness, and management and lifestyle practices data were collected using structured questionnaires and blood glucose measurements. Data analysis was done with SPSS v 25.0, where chi-squared tests and logistic regression were used to assess the relationship of educational status with DM prevalence and its management. Results: The result showed that DM was higher among the uneducated group which was 32% compare to the educated group which was 18%. The participants who were educated had better understanding of DM, better compliance with the prescribed drug regimen and improved life style changes. On the other hand, the uneducated group had poor disease knowledge and worst management hence poor management of their disease condition. Conclusion: Education has a great effect on the incidence and control of DM. The study implies that there is a significant lack of knowledge about DM among the uneducated population hence the need to conduct health education to create awareness and ensure proper management of DM.

Incidence of Postoperative Diabetes Mellitus After Roux-en-Y Reconstruction for Gastric Cancer: Retrospective Single-Center Cohort Study.

Sleeve gastrectomy is an effective surgical option for morbid obesity, and it improves glucose homeostasis. In patients with gastric cancer and type 2 diabetes mellitus (DM), gastrectomy, including total gastrectomy, is beneficial for glycemic control. This study aims to clarify the effects of gastrectomy and different reconstructive techniques on the incidence of postoperative DM in patients with gastric cancer. This retrospective, single-center, cohort study included 715 patients without DM who underwent total gastrectomy at the Tokyo Metropolitan Bokutoh Hospital between August 2005 and March 2019. Patients underwent reconstruction by Roux-en-Y (RY) gastric bypass or other surgical techniques (OT), with DM onset determined by hemoglobin A1c levels or medical records. Analyses included 2-sample, 2-tailed t tests; χ2 tests; and the Kaplan-Meier method with log-rank tests to compare the onset curves between the RY and OT groups, along with additional curves stratified by sex. A Swimmer plot for censoring and new-onset DM was implemented. Stratified data analysis compared the RY and OT reconstruction methods. The hazard ratio was 1.52 (95% CI 1.06-2.18; P=.02), which indicated a statistically significant difference in the incidence of new-onset diabetes between the RY and OT groups in patients with gastric cancer. The hazard ratio after propensity score matching was 1.42 (95% CI 1.09-1.86; P=.009). This first-of-its-kind study provides insight into how different methods of gastric reconstruction affect postoperative diabetes. The results suggest significant differences in new-onset DM after surgery based on the reconstruction method. This research highlights the need for careful surgical planning to consider potential postoperative DM, particularly in patients with a family history of DM. Future studies should investigate the role of gut microbiota and other reconstructive techniques, such as laparoscopic jejunal interposition, in developing postoperative DM.

Peer Review of "Incidence of Postoperative Diabetes Mellitus After Roux-en-Y Reconstruction for Gastric Cancer: Retrospective Single-Center Cohort Study".

Peer Review of "Incidence of Postoperative Diabetes Mellitus After Roux-en-Y Reconstruction for Gastric Cancer: Retrospective Single-Center Cohort Study".

Author's Response to Peer Reviews of "Incidence of Postoperative Diabetes Mellitus After Roux-en-Y Reconstruction for Gastric Cancer: Retrospective Single-Center Cohort Study".

Author's Response to Peer Reviews of "Incidence of Postoperative Diabetes Mellitus After Roux-en-Y Reconstruction for Gastric Cancer: Retrospective Single-Center Cohort Study".

The Prevalence of Comorbidities Associated with Multiple Sclerosis in Saudi Arabia.

Multiple sclerosis (MS) is a chronic, immune mediated demyelinating illness of the central nervous system. This study looks at various comorbidities associated with MS, focusing on their impact on disease progression. Understanding comorbidities in MS is important as it can impact treatment selection and overall disease management and prognosis. Our aim is to show the prevalence of comorbidities along with MS. This research focuses on the comorbidities associated with MS and their impact on disease progression in the Arab Gulf region, with a special emphasis on Jeddah, Saudi Arabia. A retrospective record review was conducted from July 2022 to July 2023. The study included 286 patients, selected based on a definitive MS diagnosis in accordance with McDonald's 2017 criteria. Data collected included demographic information, MS type, duration of diagnosis, type of disease modifying therapy (DMT) used, Expanded Disability Status Scale (EDSS) score, and type of comorbidities. The majority of the patients were female (70%) with an average age of 36 years. Most patients had relapsing remitting MS, and the majority were on DMTs, with fingolimod being the most common. Nearly half of the patients had comorbidities, with mood disorders, diabetes mellitus (DM), migraine, and hypertension (HTN) being prevalent. A significant positive association was found between the EDSS scores and both DM and HTN, but there was no significant link with migraine. The findings indicate that individuals with MS have an increased risk of developing comorbidities such as migraine, DM, and HTN. Emphasizing a healthy lifestyle could potentially reduce the incidence of DM and HTN and their related vascular complications. The research also notes the prevalence of mood disorders among the MS population, although it remains inconclusive whether these are separate comorbid conditions or inherent symptoms of MS.

Effect of Ajwa Date Fruit (Phoenix dactylifera) Methanol Extract on Blood Glucose Levels in Mice with Diabetes Mellitus

Highlights: The widespread incidence of DM leads to costly treatments and often results in undesirable side effects. Flavonoids in ajwa date fruit are believed to lower blood glucose levels through several mechanisms. Methanol extract of ajwa date fruit can effectively lower blood glucose levels in diabetic mice at specific optimal doses. Abstract Introduction: High diabetes mellitus (DM) cases result in costly medical expenses. Ajwa date fruit contains triterpenoids, carbohydrates, and flavonoids believed to lower blood glucose, which requires research validation using methanol extract on streptozotocin (STZ)-induced mice. This study aimed to determine the effect of methanol extract of ajwa dates with several dose levels, namely 3 g/WB, 5 g/WB, and 7 g/WB, given orally to mice induced by STZ. Methods: This study utilized a randomized pre- and post-test control group design to assess ajwa date fruit methanol extract effects on blood glucose in Swiss-Webster mice (Mus musculus). The mice were divided into four groups: Group K (6 mice without date extract intervention), P1 (6 mice with 3 g/WB/day oral dose date extract intervention), P2 (7 mice with 5 g/WB/day oral dose date extract intervention), and P3 (7 mice with 7 g/WB/day oral dose date extract intervention) and were induced with 100 mg/WB streptozotocin. Administered daily for three weeks, ajwa dates fruit extract showed varying impacts. Weekly blood glucose measurements and analysis of variance (ANOVA) in the International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) version 27.0 disclosed significant group differences. Results: In the third week, blood glucose measurements revealed significant differences (p = 0.017), with an optimal reduction in P3 (7 mice with 7 g/WB/day oral dose date extract intervention). Conclusion: In the third week, ajwa dates fruit extract, at an optimal 7 g/WB dose, effectively reduced blood glucose levels via flavonoid hypoglycemic mechanisms.

Incidence of Various Tuberculous Lesions in Indian Patients with Diabetes Mellitus: A Cross-Sectional Study

Background: Globally, TB is a major health issue, especially in low- and middle-income nations. Diabetes mellitus (DM) increases TB risk and complicates treatment. Due to the greatest worldwide TB burden and rising DM incidence, India faces a double public health problem. This study investigated the incidence and types of tuberculous lesions in Indian patients with diabetes mellitus. Methods: A total of 250 individuals with a history of DM and respiratory symptoms were included. Data were collected through patient interviews, clinical examinations, and diagnostic tests. The association between diabetes-related factors and the incidence of tuberculous lesions was analyzed. Results: Out of 250 patients, 70 (28%) were diagnosed with tuberculous lesions. Pulmonary tuberculosis was the most common type (16%), followed by extrapulmonary tuberculosis (8%) and disseminated tuberculosis (4%). The duration of diabetes and higher HbA1c levels were considerably correlated with an increased risk of tuberculous lesions (p&lt;0.05). Patients commonly presented with cough with sputum (85.7%), weight loss (78.6%), and loss of appetite (71.4%). Sputum examination for Acid-Fast Bacilli (AFB) was positive in 64.3% of cases, and chest X-rays showed lesions in 71.4% of patients. Conclusion: The study highlights a significant incidence of tuberculous lesions among diabetic patients, with pulmonary tuberculosis being the predominant type. Poor glycemic control and longer duration of diabetes are critical risk factors. These findings emphasize the need for regular TB screening and proactive management in diabetic patients to prevent complications and improve outcomes. Recommendation: Healthcare providers should integrate routine TB screening into the care protocols for diabetic patients, particularly those with poor glycemic control and long-standing diabetes. Public health strategies should focus on the dual burden of TB and DM to enhance early detection and treatment, thereby improving patient outcomes. Keywords: Tuberculosis, Diabetes Mellitus, Incidence, Glycemic Control

Anamnestic, clinical, laboratory and molecular genetic characteristics of patients with neonatal diabetes mellitus

BACKGROUND: Currently, there is an increase in the incidence of diabetes mellitus throughout the world, including the steadily increasing number of rare, genetically determined forms of diabetes. Of particular interest are monogenic forms, including neonatal diabetes mellitus, which is a rare heterogeneous disease that manifests, as a rule, in the first 6 months of a child’s life, characterized by a severe labile course and a high risk of complications. Neonatal diabetes mellitus is a rare heterogeneous disease that usually manifests itself in the first 6 months of a child’s life, characterized by a severe, labile course and a high risk of complications. Currently, more than 25 genes are known, mutations in which cause both permanent and transient neonatal diabetes mellitus, as well as syndromic variants of this disease, which are of particular interest due to their severity and polymorphic clinical picture. In this regard, timely verification of the diagnosis is of particular importance. AIM: The aim of this study is to increase the efficiency of diagnosis of neonatal diabetes mellitus based on the analysis of anamnestic, clinical, laboratory and molecular genetic characteristics of patients. MATERIALS AND METHODS: 14 patients with transient and permanent neonatal diabetes mellitus were examined. RESULTS: 11 (78.6%) patients had isolated neonatal diabetes, in three of them the disease was verified in the structure of hereditary syndromes (Wolcott–Rallison syndrome, IPEX syndrome and Donohue syndrome). According to molecular genetic analysis, 14 variants were found in the genes ABCC8, KCNJ11, GCK, GATA6, WFS1, CACNA1D, EIF2AK3, FOXP3, PAX4, INSR, IGF1R, three of which were not previously described in the literature. CONCLUSIONS: The clinical heterogeneity identified in patients is determined primarily by the diversity of verified variants in causative genes. New variants in the CACNA1D and IGF1R genes that may be associated with the development of NDM, remain poorly understood and require further research.

Impact of the use of a smartphone‐based blood glucose management system within a maternal diabetes service

AbstractBackground: The incidence of gestational diabetes mellitus is increasing, placing more demand on pregnancy diabetes services.Aims: This study aimed to explore the impact of implementing GDm‐Health, a remote blood glucose monitoring application (app), on a tertiary pregnancy diabetes service.Methods: This retrospective cohort study was conducted as part of a quality improvement project. We assessed the frequency of interactions between patients and health care professionals, the type of interactions (face‐to‐face [f2f] or non‐f2f [via text or phone call]), effect on time to treatment initiation and women's satisfaction with the app. We compared two cohorts: cohort 1, women diagnosed in September 2019 (n=52) prior to app introduction, and cohort 2, women diagnosed in September 2020 (n=54) after app introduction. Data were collected from the electronic notes, and app satisfaction was assessed using a questionnaire.Results: Median interactions for each woman from diagnosis to delivery increased from 5 (interquartile range [IQR], 3–6) in cohort 1 to 7 (IQR, 5–10) in cohort 2 (p&lt;0.001). In cohort 2, 88.4% of interactions were non‐f2f compared to 13.7% in cohort 1. There was no change in the time to treatment initiation (19 days [cohort 1] vs 20 days [cohort 2]; p=0.59). Women using the app were satisfied with their care.Conclusions: After GDm‐Health was introduced, women had more interactions with the diabetes team; however, most were non‐f2f interactions via telephone. The app has helped health care professionals streamline the service, particularly in terms of the allocation of clinic space and appointments, and has been well received by patients.

Hubungan Pola Asuh Orang Tua terhadap Kejadian Diabetes pada Anak Usia Sekolah

Elevated blood sugar levels are a sign of a metabolic disease called Diabetes Mellitus (DM). Several factors including the environment are contributors to the incidence of DM. The role of parents is mainly related to the child's lifestyle, including diet and food intake for the child. The lifestyle fostered in the family will affect the health of children. The purpose of this study was to analysis the parenting style of parents towards early diagnosis of diabetes based on blood glucose levels in children. A cross-sectional design and descriptive correlational design were used for this study. This study involved all students at SDN 2 Kepuharjo in August 2023 involving 92 children with total sampling technique. This study used the Parental Authority Questionaire instrument, which consists of twenty question items that assess how parenting is done. Details of the characteristics of the respondents were mostly 11 years old with 47 children (51.1%) and were in grades 5 and 6. The most respondents were female with 49 children (53.3%). Working mother status was at 84 (91.3%). 53 children with less parenting (57.6%). The results of the examination of blood sugar levels obtained were 17 children (18.5%) in the high category. Conclusion There is a correlation between parenting patterns and the number of cases of diabetes in school-age children in elementary schools with a p value of 0.006.