Introduction: Liver resection is a most effective treatment for patients with operable primary or secondary liver tumours. This study assesses the outcomes of liver resection performed for primary liver lesions (PLL) versus secondary/metastatic liver lesions (SLL). Methods and Materials: The parameters were operative time, acute kidney injury (AKI), bile leak, sepsis, mortality and hospital readmission within 3 months. After excluding 12 cholangiocarcinomas resections, a total of 308 liver resections from Addenbrookes Hospital between 2015-2017 were included in this study. 66 liver resections were performed for PLL and remaining of 242 for SLL group. Relevant parameters were collected from a prospective electronic patient database. Results: The mean operative time was 403±139 versus 417±122 (P=0.38) minutes PLL group and SLL groups respectively. The incidence of postoperative AKI were not different in between the groups (6/66 versus 9/242; P=0.10). But the incidence of bile leak was significantly high in PLL group (11/66 versus 14/242; P=0.008). Similarly high incidence of postoperative sepsis noted in the PLL group compared to SLL (4/66 versus 3/242; P=0.04). Mortality, hospital readmission at 3 months were (1/66 versus 1/242; P=1) and (1/66 versus 3/242; P=0.38) respectively. Conclusion: Liver resections performed for primary liver lesions were associated with the risk of postoperative bile leak and sepsis compared to metastatic liver diseases. Further multicentre prospective study with long-term follow up is recommended.