Abstract
BackgroundFlurbiprofen axetil (FA) is a commonly prescribed agent to relieve perioperative pain, but the relationship between FA and postoperative acute kidney injury (AKI) remains unclear. This study attempted to evaluate the effects of different dose of perioperative FA on postoperative AKI.MethodsA total of 9915 patients were enrolled for this retrospective study. The clinical characteristics and the prevalence of postoperative AKI among patients non-using, using low dose (50-100 mg), middle dose (100-250 mg) and large dose (≧250 mg) of FA were analyzed respectively. The impact of different dose of FA on postoperative AKI was analyzed using univariable and multivariate logistic regression analysis.ResultsThe prevalence of postoperative AKI was 6.7% in the overall subjects and 5.1% in 2446 cases who used FA. The incidence of AKI in low dose group was significantly less than that of non use group (4.5% vs 7.2%, P < 0.001), but the incidence of AKI in large dose group was significantly higher than that in the non-use group (18.8% vs 7.2%, P < 0.001). However, there was no significant difference between patients without using FA and subjects using middle dose of FA (7.2% vs 5.6%, p = 0.355). Multivariate logistic regression analysis showed that low dose of FA was a protective factor for postoperative AKI (OR = 0.75, p = 0.0188), and large dose of FA was a risk factor for postoperative AKI (OR = 4.8, p < 0.0001).ConclusionsThe impact of FA on postoperative AKI was dose-dependent, using of low dose FA (50-100 mg) perioperatively may effectively reduce the incidence of postoperative AKI.
Highlights
Flurbiprofen axetil (FA) is a commonly prescribed agent to relieve perioperative pain, but the relationship between FA and postoperative acute kidney injury (AKI) remains unclear
Postoperative AKI is a common complication in various operation patients, and it occurs in approximately 6.3–7.4% of patients who undergo noncardiac surgery [2, 3]
Previous studies have indicated that FA could ameliorate renal injury in the rats with 5/6 kidney ablation [9, 10], but some clinical data have showed that FA could induce renal papillary necrosis [11], and even acute tubulointerstitial nephritis [12]
Summary
Flurbiprofen axetil (FA) is a commonly prescribed agent to relieve perioperative pain, but the relationship between FA and postoperative acute kidney injury (AKI) remains unclear. Postoperative AKI is a common complication in various operation patients, and it occurs in approximately 6.3–7.4% of patients who undergo noncardiac surgery [2, 3]. Flurbiprofen axetil (FA) is an injectable nonselective cyclooxygenase (COX) inhibitor It can selectively accumulate in surgical incision and inflammatory site to reduce the inflammation and pain because of composed emulsified lipid microspheres [7]. In order to explore the exact effects of FA on postoperative AKI, we performed this large retrospective study to guide future clinical applications of FA
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
