Tomato leaf curl New Delhi virus (ToLCNDV), a bipartite begomovirus, is an emerging problem for agricultural crops in Pakistan (Zaidi et al. 2016). In 2017, severe symptoms and high incidence of yellow mosaic and leaf curl disease attributable to infection by ToLCNDV (Sohrab et al. 2003) was observed in luffa (Luffa acutangula) grown in the Malakand region (Khyber Pakhtunkhwa province). Several plants of Physalis minima, a common weed plant in and around luffa fields, also exhibited severe mottling and leaf curling symptoms. Leaves from three symptomatic plants of luffa and P. minima tested positive for ToLCNDV using polyclonal antibodies (DSMZ, Germany) in double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA). To further confirm the identity of the virus, DNA was extracted from all the collected leaf samples using a CTAB-based DNA extraction method (Doyle and Doyle 1990). Polymerase chain reaction (PCR) was conducted using ToLCNDV-specific primers ToLCNDV-up (GAACTATGG TGAAGCGACCAGCAGA) and ToLCNDV-do (ACACAGGTCCTTAGGTACCTGG) as described by Alfaro-Fernandez et al. (2016). One ToLCNDV-positive control (accession no. EF620534 obtained from NWFP Agriculture University Peshawar, Pakistan) was also included in PCR, and a healthy plant was used as a negative control. A single amplicon of expected size (∼914 bp) was amplified by PCR from all the ELISA-positive samples of luffa and P. minima including the positive control, whereas no amplicon was amplified from healthy samples. One amplicon each from luffa and P. minima was sequenced in both directions, and the consensus sequences were deposited in GenBank under accession numbers MK560176 and MK560177, respectively. BLASTn analyses of the sequence from luffa (MK560176) and P. minima (MK560177) showed the highest identity (99%) with a ToLCNDV isolate (AF448058) reported on tomato in Malakand region (Shih et al. 2003). Infection of luffa by ToLCNDV was recently reported in Pakistan (Anwar et al. 2020). This is the first report of this virus naturally infecting P. minima. Based on our findings, further targeted surveys must be undertaken to advance our knowledge on alternative hosts of this virus in the region.