Abstract
Targeted next generation sequencing (NGS) is now utilized for embryonic aneuploidy screening. The increased resolution of NGS presents the opportunity to detect mosacism. While a direct relationship between advanced maternal age and aneuploidy is well established, the data linking ovarian age and mosaicism is limited. Although mosaicism results from mitotic errors, advanced ovarian age could theoretically hinder the proper segregation of chromosomes via defects in cohesion molecules and microtubules.
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