Incidence Of Knee Osteoarthritis Research Articles

Acupuncture combined with traditional Chinese medicine for knee osteoarthritis: A protocol for systematic review and meta-analysis

With the aging of society, the incidence of knee osteoarthritis (KOA) is increasing year by year, which seriously affects the quality of life. Acupuncture therapy has been widely used in the treatment of osteoarthritis, but there is no complete systematic review on acupuncture combined with traditional Chinese medicine. Therefore, this study aims to clarify the efficacy and safety of acupuncture combined with traditional Chinese medicine in the treatment of KOA through systematic review and meta-analysis. A structured and systematic literature search will be conducted in the following databases up to March, 20, 2022: PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chinese Scientific and Journal Database, Wan Fang database and 2 clinical trials register platforms: Chinese Clinical Trial Registry, ClinicalTrials.gov (www.ClinicalTrials.gov/). We will use the Review Manager 5.4 software provided by the Cochrane Collaborative Network for statistical analysis. We then assessed the quality and risk of the included studies and observed the outcome measures. This meta-analysis further established the efficacy of acupuncture combined with traditional Chinese medicine in the treatment of KOA. This meta-analysis aims to investigate the efficacy of acupuncture combined with traditional Chinese medicine on patients with KOA and provide reliable evidence. To provide more options for clinicians and patients in the treatment of KOA.

Osteoarthritis: insights into pathogenesis and futuristic treatment strategies

<p class="abstract">Osteoarthritis is the most common musculoskeletal condition world over that causes significant health, economic, and societal burdens. Till date, no therapeutic approaches have been able to stop or delay the progression of osteoarthritis satisfactorily. Structural and clinical features of the disease are characterized by a high inter-patient variability. This heterogeneity is believed to be a major factor associated with the complexity of osteoarthritis and the on-going difficulty to identify a single therapy for all sub-groups. The objective of this review is to highlight recent advances in the understanding of the pathophysiology of osteoarthritis and latest biological treatments available, their limitations and to bring to notice the latest state-of-the-art on-going research on novel therapies. For this study we searched different online databases such as PubMed and Cochrane Library from inception to January 2022. We identified eligible studies on the pathophysiologic findings, prevalence, or incidence of knee osteoarthritis, available treatments, and current research for future therapies. Besides the availability of vast literature on cartilage extracellular matrix and its changes in osteoarthritis, the complicated mechanism of the disease still has missing links in the chain. Presently, biological treatments such as platelet rich plasma, bone marrow mesenchymal stem cells and autologous fragmented adipose tissue containing structural vascular fraction are commonly used. In future, gene therapy could become a potential option for treating the disease.<strong> </strong>More extensive insights into the pathophysiology of osteoarthritis will be helpful in designing therapies that can curb structural progression and promote cartilage regeneration thus providing more potent relief from painful and disabling condition associated with osteoarthritis.</p>

Penyuluhan Osteoarthritis Lutut pada Komunitas Senam Sehat RW 6 Pabelan Kecamatan Kartasura Kabupaten Sukoharjo

Osteoarthritis is a disease that is often found in the elderly. The prevalence of knee osteoarthritis shows that adults in the 60-64 year age group are 22%, while men with the same age group are found to have 23% of right knee osteoarthritis while the left knee is 16.3%. While osteoarthritis in women, the right knee is 24% and the left knee is 24.7%. The incidence of knee osteoarthritis in Indonesia is around 30%, namely at the age of 40-60 years, and 60% at the age of more than 61 years. The partner of this service activity is the Healthy Gymnastics Community RW 6 Pabelan, Kartasura District, Sukoharjo Regency in preventing osteoarthritis and knowing the understanding of the education. The educational method provided by the lecture method is delivered with poster media. To measure the level of understanding and knowledge, pre-test and post-test were carried out on 8 respondents with the pre-test results obtained that 1 person (12.5%) had knowledge in the good category, 7 people (87.5%) had sufficient knowledge. and the post-test results obtained 2 people (25%) have knowledge in the sufficient category, 6 people (75%) have knowledge in the good category. Participants were enthusiastic in participating in this activity and there was an increase in understanding by the Healthy Gymnastics Community RW 6 Pabelan, Kartasura District, Sukoharjo Regency about prevention management in osteoarthritis.

Association of Diabetes Mellitus Status and Hyperglycemia With Symptomatic Knee Osteoarthritis.

Emerging evidence indicates that hyperglycemia has an adverse impact on the knee joint which, in turn, may increase the risk of knee osteoarthritis (OA), but evidence from the real-life settings of large-scale cohort studies remains unclear. We sought to evaluate the association of glycemic control and the risk of symptomatic knee OA in a community-based cohort of older adults. We conducted a prospective analysis of 10,730 participants without knee OA. Comprehensive blood biomarker data were obtained. Diabetes mellitus (DM) was defined mainly using a glycosylated hemoglobin (HbA1c ) level of ≥6.5%; poor glycemic control in individuals with DM was defined as an HbA1c level of ≥7%. We fit Cox regression models, stratified according to DM status. We evaluated the hazards associated with HbA1c and fasting blood glucose levels using a spline model. During a median follow-up of 5 years, knee OA developed in 1,089 participants (108 with DM and 971 without). Knee OA was related to DM (hazard ratio [HR] 1.29 [95% confidence interval (95% CI) 1.02-1.78]), bad glycemic regulation in DM patients (HR 1.41 [95% CI 1.05-2.09]), and long-term DM (≥5 versus <5 years; HR 1.49 [95% CI 1.02-2.17]). High levels of HbA1c (>7.7% and 61 mmoles/mole) and fasting blood glucose (>186 mg/dl) were significantly associated with higher risk of incident knee OA. DM, bad glycemic management, and long-term DM are potential risk factors of symptomatic knee OA independent of age and body mass index. Targeting blood glucose, in addition to bodyweight, may be an important avenue for prevention of knee OA.

The KNee OsteoArthritis Prediction (KNOAP2020) challenge: An image analysis challenge to predict incident symptomatic radiographic knee osteoarthritis from MRI and X-ray images

The KNee OsteoArthritis Prediction (KNOAP2020) challenge was organized to objectively compare methods for the prediction of incident symptomatic radiographic knee osteoarthritis within 78 months on a test set with blinded ground truth. The challenge participants were free to use any available data sources to train their models. A test set of 423 knees from the Prevention of Knee Osteoarthritis in Overweight Females (PROOF) study consisting of magnetic resonance imaging (MRI) and X-ray image data along with clinical risk factors at baseline was made available to all challenge participants. The ground truth outcomes, i.e., which knees developed incident symptomatic radiographic knee osteoarthritis (according to the combined ACR criteria) within 78 months, were not provided to the participants. To assess the performance of the submitted models, we used the area under the receiver operating characteristic curve (ROCAUC) and balanced accuracy (BACC). Seven teams submitted 23 entries in total. A majority of the algorithms were trained on data from the Osteoarthritis Initiative. The model with the highest ROCAUC (0.64 (95% confidence interval (CI): 0.57-0.70)) used deep learning to extract information from X-ray images combined with clinical variables. The model with the highest BACC (0.59 (95% CI: 0.52-0.65)) ensembled three different models that used automatically extracted X-ray and MRI features along with clinical variables. The KNOAP2020 challenge established a benchmark for predicting incident symptomatic radiographic knee osteoarthritis. Accurate prediction of incident symptomatic radiographic knee osteoarthritis is a complex and still unsolved problem requiring additional investigation.

Whole grain consumption and risk of radiographic knee osteoarthritis: a prospective study from the Osteoarthritis Initiative.

To assess the association of whole grain consumption with the risk of incident knee OA. We followed 2846 participants in the Osteoarthritis Initiative ages 45-79 years. Participants were free from radiographic knee OA (Kellgren-Lawrence grade <2) in at least one knee at baseline. Dietary data from baseline were obtained using the Block Brief Food Frequency Questionnaire. We defined radiographic knee OA incidence as a Kellgren-Lawrence grade ≥2 during the subsequent 96 months. Cox proportional hazards models were used to assess the association between whole grain food intake and the risk of incident knee OA. During the 96 month follow-up, 518 participants (691 knees) developed incident radiographic knee OA. Higher total whole grain consumption was significantly associated with a lower knee OA risk [hazard ratio (HR)quartile 4vs1 = 0.66 (95% CI 0.52, 0.84), P for trend < 0.01] after adjusting for demographic and socio-economic factors, clinical factors and other dietary factors related to OA. Consistently, a significant inverse association of dark bread consumption with knee OA risk was observed [HRquartile 4vs1 = 0.68 (95% CI 0.53, 0.87), P for trend < 0.01). In addition, we observed a significant inverse association between higher cereal fibre intake and reduced knee OA risk [HRquartile 4vs1 = 0.61 (95% CI 0.46, 0.81), P for trend < 0.01). Our findings revealed a significant inverse association of whole grain consumption with knee OA risk. These findings provide evidence that eating a diet rich in whole grains may be a potential nutritional strategy to prevent knee OA.

Risk Assessment for Hip and Knee Osteoarthritis Using Polygenic Risk Scores.

ObjectivePolygenic risk scores (PRS) allow risk stratification using common single‐nucleotide polymorphisms (SNPs), and clinical applications are currently explored for several diseases. This study was undertaken to assess the risk of hip and knee osteoarthritis (OA) using PRS.MethodsWe analyzed 12,732 individuals from a population‐based cohort from the Rotterdam Study (n = 11,496), a clinical cohort (Cohort Hip and Cohort Knee [CHECK] study; n = 908), and a high‐risk cohort of overweight women (Prevention of Knee OA in Overweight Females [PROOF] study; n = 328), for the association of the PRS with prevalence/incidence of radiographic OA, of clinical OA, and of total hip replacement (THR) or total knee replacement (TKR). The hip PRS and knee PRS contained 44 and 24 independent SNPs, respectively, and were derived from a recent genome‐wide association study meta‐analysis. Standardized PRS (with Z transformation) were used in all analyses.ResultsWe found a stronger association of the PRS for clinically defined OA compared to radiographic OA phenotypes, and we observed the highest PRS risk stratification for TKR/THR. The odds ratio (OR) per SD was 1.3 for incident THR (95% confidence interval [95% CI] 1.1–1.5) and 1.6 (95% CI 1.3–1.9) for incident TKR in the Rotterdam Study. The knee PRS was associated with incident clinical knee OA in the CHECK study (OR 1.3 [95% CI 1.1–1.5]), but not for the PROOF study (OR 1.2 [95% CI 0.8–1.7]). The OR for OA increased gradually across the PRS distribution, up to 2.1 (95% CI 1.4–3.2) for individuals with the 10% highest PRS compared to the middle 50% of the PRS distribution.ConclusionOur findings validated the association of PRS across OA definitions. Since OA is becoming frequent and primary prevention is not commonly applicable, PRS‐based risk assessment could play a role in OA prevention. However, the utility of PRS is dependent on the setting. Further studies are needed to test the integration of genetic risk assessment in diverse health care settings.

The Role of Plasma, Platelets, and Growth Factors in Knee Osteoarthritis: The Evidence-Based Medicine 2022

Knee osteoarthritis greatly affects the quality of life of numerous people worldwide. Study in 2020 estimated that the global incidence of knee osteoarthritis was 203 per 10,000 person-years and the global prevalence was 16%. Biologic derivatives, such as plasma, platelets, and growth factors, have gained popularity due to their efficacy and safety; however, several controversies related to the treatment of knee osteoarthritis with orthobiologics still exist. The purpose of this review is to provide recent evidence about the use of growth factors as orthobiologics for the treatment of knee osteoarthritis, to summarize the up-to-date clinical practice guidelines provided by American Academy of Orthopedic Surgeons (AAOS) and American College of Rheumatology (ACR), and to discuss these guidelines based on the latest research.

Are Athletes Playing for Osteoarthritis? A Systematic Review

Abstract &#x0D; &#x0D; Background &#x0D; An athlete suffers from many injuries in his sports career which may be due to some trauma or maybe atraumatic. Athletes involved in the sports of long-running remains worried about knee osteoarthritis (O.A) and a question always remain in a debate that physical activity is a risk of O.A and the athletes are running for osteoarthritis. This systematic review was conducted to synthesize the evidence on the quantitative association between participation in specific sports and the occurrence of Knee OA. This systematic review will also analyze the effect of sports injuries on knee OA.&#x0D; Methods&#x0D; Three electronic databases including PubMed, Scopus, and Springer link are selected for gathering the information and the articles for this study. This systematic review is based on the randomized control trials (RCTs), cohort and case-control studies published in the last 20 years (2000-2022) evaluating the symptomatic or asymptomatic tibiofemoral knee osteoarthritis change. The quality for study methodology was evaluated by using the Cochrane Effective Practice and Organization of Care Risk of Bias Tool and PRISMA checklist as a reference. Review manager, 5.4.1 Cochrane Collaboration was used for analyzing the risk for bias of individual studies.&#x0D; Results&#x0D; A total of 508 articles were searched and nine articles were selected to synthesized the results of this systematic review. Total nine articles are selected to conclude the results based on the inclusion criteria. Graph 1 is showing the study design and the number of included and excluded articles. The results are synthesized on the following levels using the PICOS model, i) comparison of running sports and incidence of knee osteoarthritis, ii) comparison of soccer, gender, and incidence of knee osteoarthritis, iii) comparison of anterior cruciate injury, the effect of treatment and incidence of knee osteoarthritis, and iv) comparison of training and prevention of knee osteoarthritis incidence.&#x0D; Conclusion&#x0D; Sports with more jumping, twisting, and knee injuries contribute to the prevalence of knee osteoarthritis. Knee osteoarthritis in athletes remains asymptomatic initially and it manifested after 15 to 20 years after the start of pathogenesis due to some knee injury, especially ACL and menisci injury.

Risk of Comorbidities Following Physician-Diagnosed Knee or Hip Osteoarthritis: A Register-Based Cohort Study.

To estimate the risk of developing comorbidities in patients after physician-diagnosed knee or hip osteoarthritis (OA). This was a cohort study using Swedish longitudinal health care register data; we studied residents in the Skåne region age ≥35 years on January 1, 2010 who were free from diagnosed hip or knee OA (n = 548,681). We then identified subjects with at least 1 new diagnosis of knee or hip OA (incident OA) between 2010 and 2017 (n = 50,942 considered exposed). Subjects without diagnosed OA were considered unexposed. From January 2010 both unexposed and exposed subjects were observed for the occurrence of 18 different predefined comorbidities until either relocation outside of the region, death, occurrence of the comorbidity, or December 2017, whichever came first. We calculated unadjusted hazard ratios (HRs) and adjusted HRs of comorbidities using Cox models with knee and hip OA as time-varying exposures. Subjects with incident knee or hip OA had 7% to 60% higher adjusted HRs (range 1.07-1.60) of depression, cardiovascular diseases, back pain, and osteoporosis than individuals without an OA diagnosis. An increased risk of diabetes mellitus was found only for knee OA (adjusted HR 1.19 [95% confidence interval 1.13-1.26]). For the rest of the diagnoses, we found either no increased risk or estimates with wide confidence intervals, excluding clear interpretations of the direction or size of effects. Incident physician-diagnosed knee and hip OA is associated with an increased risk of depression, cardiovascular diseases, back pain, osteoporosis, and diabetes mellitus. However, the latter was only found for knee OA.

Increased risk of incident knee osteoarthritis in those with greater work-related physical activity

ObjectiveOccupations involving greater physical activity may increase risk for knee osteoarthritis (OA). Existing studies have not evaluated work-related physical activity before OA onset. Hence, we aimed to evaluate the association...

Knee joint osteoarthritis in obese subjects, effects of diet and exercise on knee joint loading: a review of literature

The incidence of osteoarthritis (OA) is greater in the knee than in other joints and is increasing. This could be because of an increase in the applied loads on this joint or because of a change in the alignment of the knee joint. The aim of this review was to determine the effects of being overweight on knee joint OA. Moreover, it aimed to determine whether a change in body weight by diet or exercise influenced the loads applied on the knee joint and decreased the incidence of knee OA. A systematic literature search was carried out to find the literature published on the effects of joint loading and being overweight on knee OA in databases such as Medline, PubMed, Embase, Web of Sciences, Scopus, and Google Scholar. The key words such as knee OA and loading, knee OA and joint contact forces, knee OA and body weight were used to determine the effects of joint loading on knee OA. The quality of the studies was evaluated by use of Downs and Black tool. There were 15 studies on the effects of joint loading, overweight, and obesity on joint contact force and knee OA symptoms and three studies on the effects of weight loss, exercise, and intensive diet intervention on joint loading. The quality of these papers varied between 9 and 20. The results of this review showed that obese subjects are at high risk of knee OA because of change in alignment of the knee joint and also overloading of the joint. Use of approaches such as diet and exercise may decrease the loads applied on the joint and decrease the incidence of knee OA.

Comparison of the knee joint reaction force between individuals with and without acute anterior cruciate ligament rupture during walking

BackgroundAnterior cruciate ligament plays a significant role in knee joint stability. It is claimed that the incidence of knee osteoarthritis increases in individuals with anterior cruciate ligament (ACL) rupture. The aim of this study was to evaluate the knee joints reaction force in ACL rupture group compared to normal subjects.MethodFifteen patients with acute ACL rupture and 15 healthy subjects participated in this study. The ground reaction force (GRF) and kinematic data were collected at a sampling rate of 120 Hz during level-ground walking. Spatiotemporal parameters, joint angles, muscle forces and moments, and joint reaction force (JRF) of lower extremity were analyzed by OpenSIM software.ResultsThe hip, knee and ankle joints reaction force at loading response and push-off intervals of the stance phase during walking was significantly higher in individuals with ACL rupture compared to healthy controls (p value < 0.05). Walking velocity (p value < 0.001), knee (p value = 0.065) and ankle (p value = 0.001) range of motion in the sagittal plane were significantly lower in the patients with ACL rupture compared to healthy subjects. The mean value of vertical GRF in the mid-stance, the peak of the hip adduction moment in loading response and push-off phases, the hip abductor, knee flexor and vastus intermedius part of quadriceps muscle forces were significantly higher compared to healthy subjects (p < 0.05) while vastus medialis and vastus lateralis produced significantly lower force (p < 0.001).ConclusionsBased on results of this study, lower limb JRF was higher in those with ACL rupture compared to healthy subjects may be due to the compensatory mechanisms used by this group of subjects. An increase in knee JRF in patients with ACL rupture may be the reason for the high incidence of knee OA.

Assessment of clinical outcome of platelet rich plasma (PRP) injection in progression of mild to moderate osteoarthritis patients, a retrospective study

Background and Objectives: Global reports (2020) state that an annual 86.7 million people (age >20 years) are diagnosed with incident knee Osteoarthritis. Various therapies and medications have been given to treat this condition and one such upcoming therapy is the use of Platelet-rich plasma. In spite of the promising outcomes, some experts in the field are yet skeptical about the use of Platelet-rich plasma therapy to treat osteoarthritis. In this study, the investigators attempt to measure the clinical outcome of platelet-rich plasma therapy in patients with progression of mild to moderate osteoarthritis. Methods: Analysis of 102 patient records was carried out from the years 2016-2020 to assess the clinical outcome of the intra-articular Platelet Rich Plasma (PRP) injection in the progression of mild to moderate osteoarthritis patients from the period of pre-injection to 12 months post-injection. Assessment tools such as the VAS and the WOMAC score were used. IBM SPSS software version 1.0 was used for the statistical data analysis. Results: Medical records analyzed of the patients showed a gradual decrease in pain, observed over a period of 12 months post-injection (as assessed by the VAS and WOMAC score). Significant reduction in swelling (Friedman test: Chi-square = 199.68, P< 0.0001) and tenderness (Friedman test: Chi-square = 199.14, P< 0.0001) was also observed. Conclusion: A significant reduction in pain, swelling, tenderness and improvement in function was observed post 12 months of the injection given. The results are encouraging when compared to pre-injection pain and symptoms, suggesting a positive clinical use of PRP injections for mild to moderate osteoarthritic patients.

PROSPECTIVE ASSOCIATION OF METABOLOMIC PROFILES OF DIETARY PATTERNS WITH INCIDENT KNEE OSTEOARTHRITIS: A CASE-COHORT STUDY FROM THE OSTEOARTHRITIS INITIATIVE

Purpose: Knee osteoarthritis (KOA) significantly impacts the quality of life and imposes a huge financial burden on societies. Unfortunately, its pathogenesis is still poorly understood and no effective disease modifying drugs have been developed. Dietary factors associated with inflammation, obesity and other metabolic risk factors appear to play a role in OA pathogenesis. In this study, we aimed to investigate the association of metabolomic profiles of dietary patterns with the incidence of knee OA.

THE LARGER MRI-DETECTED MEDIAL TIBIAL OSTEOPHYTE WIDTH, THE HIGHER RISK FOR UNSTABLE MENISCUS TEAR IN KNEE OA -THE BUNKYO HEALTH STUDY (BHS)-

Purpose: Osteoarthritis of the knee (knee OA) is a slowly but progressive joint disease and is most common form of joint dysfunction and knee pain. Strong mechanical stress subjected to joint surface is one of the major risk factors for incidence and progression of knee OA: e.g. varus alignment increases risk of medial knee OA progression, valgus alignment increases risk of lateral knee OA progression, obesity is also a risk factor of knee OA, and burden of malalignment predicts decline in physical function.

MEDIAL JOINT SPACE WIDTH AND JOINT LINE CONVERGENCE ANGLE WERE CORRELATED WITH CLINICAL RESULTS AFTER HIGH TIBIAL OSTEOTOMY(HTO) IN PATIENTS WITH MEDIAL KNEE OSTEOARTHRITIS

Purpose: There is an urgent need for the establishment of the methods for early diagnosis and early treatment of knee osteoarthritis (OA). Strong mechanical stress subjected to joint surface is one of the major risk factors for incidence and progression of knee OA. Furthermore, strong mechanical stress is currently considered to be placed in an upstream position among existing risk factors of knee OA: e.g. varus alignment increases risk of medial knee OA progression, valgus alignment increases risk of lateral knee OA progression, obesity is also a risk factor of knee OA, and burden of malalignment predicts decline in physical function.

POTENTIAL SURROGATE OUTCOMES FOR INCIDENT KNEE OSTEOARTHRITIS AMONG OVERWEIGHT AND OBESE WOMEN

Purpose: Experts in the field of OA suggested that a shift in research focus towards the early disease stage is needed; here joint damage might still be reversible, pain is not chronic, and physical functioning is not heavily impaired. Studying incident knee OA among patients with early-stage disease requires very long follow-up when established measures of knee OA, e.g. Kellgren & Lawrence (KL) grade ≥2 or the ACR-criteria), are used. Validated surrogate outcomes of established knee OA, can boost the research on new disease- and symptom-modifying treatments within the ‘window of opportunity’ of early-stage knee OA.

Recreational Physical Activity and Risk of Incident Knee Osteoarthritis: An International Meta-Analysis of Individual Participant-Level Data.

The effect of physical activity on the risk of developing knee osteoarthritis (OA) is unclear. We undertook this study to examine the relationship between recreational physical activity and incident knee OA outcomes using comparable physical activity and OA definitions. Data were acquired from 6 global, community-based cohorts of participants with and those without knee OA. Eligible participants had no evidence of knee OA or rheumatoid arthritis at baseline. Participants were followed up for 5-12 years for incident outcomes including the following: 1) radiographic knee OA (Kellgren-Lawrence [K/L] grade ≥2), 2) painful radiographic knee OA (radiographic OA with knee pain), and 3) OA-related knee pain. Self-reported recreational physical activity included sports and walking/cycling activities and was quantified at baseline as metabolic equivalents of task (METs) in days per week. Risk ratios (RRs) were calculated and pooled using individual participant data meta-analysis. Secondary analysis assessed the association between physical activity, defined as time (hours per week) spent in recreational physical activity and incident knee OA outcomes. Based on a total of 5,065 participants, pooled RR estimates for the association of MET days per week with painful radiographic OA (RR 1.02 [95% confidence interval (95% CI) 0.93-1.12]), radiographic OA (RR 1.00 [95% CI 0.94-1.07]), and OA-related knee pain (RR 1.00 [95% CI 0.96-1.04]) were not significant. Similarly, the analysis of hours per week spent in physical activity also showed no significant associations with all outcomes. Our findings suggest that whole-body, physiologic energy expenditure during recreational activities and time spent in physical activity were not associated with incident knee OA outcomes.

The application of whole-body vibration training in knee osteoarthritis

With the gradual increase of the aging population in Chinese society, the incidence of knee osteoarthritis showed an increasing trend. However, there are very few practical solutions for it. As a novel neuromuscular training technique, whole-body vibration training has become a candidate for treating knee osteoarthritis. In this review, we firstly elaborated on the modeofaction and influence factors of the whole-body vibration training. Next, we summarized its effects in knee osteoarthritis, including improving knee function and some uncertain muscle function and proprioception effects. Next, we also summarized its possible mechanisms, including improving bone microstructure, delaying articular cartilage degeneration, modulating inflammatory cells and inflammatory factors. Then, we summarized the clinical effectiveness of whole-body vibration training by analyzing some clinical randomized controlled trials. Finally, based on the above summary, we analyzed and listed the limitations of whole-body vibration training in treating knee osteoarthritis and found the shortcomings in the existing studies. This review provides ideas for the future application of whole-body vibration training in the treatment of knee osteoarthritis.