Abstract
Purpose: Experts in the field of OA suggested that a shift in research focus towards the early disease stage is needed; here joint damage might still be reversible, pain is not chronic, and physical functioning is not heavily impaired. Studying incident knee OA among patients with early-stage disease requires very long follow-up when established measures of knee OA, e.g. Kellgren & Lawrence (KL) grade ≥2 or the ACR-criteria), are used. Validated surrogate outcomes of established knee OA, can boost the research on new disease- and symptom-modifying treatments within the ‘window of opportunity’ of early-stage knee OA.
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