Introduction Sensory integration therapy can improve language skills, attention, and social interactions in children with ASD. However, it is also important to note that research in this field is ongoing and more studies are needed to confirm the effectiveness of these therapies. The present study is aimed to identify the effects of occupational therapy-based sensory processing skill therapies in improving the autism severity and QoL among ASD children. Methodology The intervention was performed for 12-weeks, 6 sessions per week, each session based on 60 minutes of duration. The treatment protocol comprised four sensory processing skills in which Each child was trained on every skill for 15 minutes, making a total of 60 minutes of duration for a single session. Results Significant improvements in CARS, CGAS and PedsQL (p<0.001) were observed after 12-weeks of intervention. Conclusion Sensory processing skills therapies are a practical treatment approach in optimizing sensory load among ASD children. Keywords Art therapies, Autism, Quality of life, Sensory integration