Long-term alcohol abuse causes psycho-emotional and cognitive impairment, including severe dementia. Oxidative stress is considered one of the main mechanisms in the cognitive disorders pathophysiology caused by long-term alcoholism. In this regard, the search for substances capable of correcting mitochondrial dysfunction and oxidative stress that arise as a result of prolonged ethanol consumption is relevant. Of particular interest in the complex treatment of alcoholic encephalopathy is Chinese hyssop (Lophanthus chinensis), used in Tibetan and Mongolian traditional medicine for liver diseases, as well as a means of improving the functional state of the body and metabolism, slowing down the aging process. Material and methods. Alcohol intoxication was modeled in Wistar rats by per os administration of a 40 % ethanol solution in a volume of 10 ml/kg for six weeks. The L. chinensis dry extract at a dose of 100 mg/kg was administered to animals per os starting from the third week, an hour after ethanol. On day 45, the content of malondialdehyde (MDA), reduced glutathione (GSH), activity of catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase, NADH dehydrogenase and succinate dehydrogenase complex, concentration of ATP werei determined spectrophotometrically in the animal brain homogenate. Results. It was found that L. chinensis extract increases the activity of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase (by 10 %, р = 0.016, by 31 %, р = 0.001, by 30 %, р = 0.041, by 29 %, р = 0.009, respectively) and GSH content (by 24 %, р = 0.019), and also reduces the concentration of MDA (by 20 %, р = 0.014) in brain tissue. A decrease in the intensity of oxidative stress enhances the functioning of enzymatic complexes I (by 23 %, р = 0.017) and II of the mitochondrial respiratory chain (by 72 %, р = 0.001) and increases the ATP content (by 23 %, р = 0.029) in the rat’s brain. Conclusions. L. chinensis extract exhibits antioxidant effects and stimulates energy processes in neurodegenerative processes in the brain caused by long-term alcoholism.
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