The spread of areas under crops of winter barley is associated with great national economic importance, since its products include malt, feed grain, hay and are used in the food industry. The main reasons for the production of an insufficient amount of winter barley grain is a violation of cultivation technologies. Among the main ones are the untimely use of means of protection or the absence of these measures to regulate the number of harmful organisms in crops of winter barley to an economically imperceptible level. Violation of the scientific foundations of agriculture and changes in weather and climatic conditions led to an increase in the development of diseases, the number of weeds in winter barley crops. During seed dressing with modern highly effective dressing agents, conditions are created under which winter barley plants better tolerate stress, improve the development of their root system, which is important for plants in preparation for winter entry. The infestation of winter barley fields is accompanied by the appearance of both early and late crops, a certain periodicity of the appearance of weeds of different biological groups. Accordingly, in different conditions and in different fields, the weed structure can differ significantly. Therefore, the development of highly effective systems for protecting winter barley crops from weeds largely depends on the completeness of the study of phytocenoses and the species composition of weeds. The introduction of herbicides on crops of winter barley contributed to a sharp decrease in weeds. Dicotyledonous weeds were almost completely destroyed, in the agrocenoses of winter barley, mainly cereal weeds remained, but they did not pose a threat to barley plants. Control of barley and weed plant diseases in agrocenoses provides an increase in crop yields, as well as an improvement in grain quality. To obtain the planned level of grain yield of winter barley of appropriate quality, it is recommended before sowing barley seeds to treat with a disinfectant Scenik 80 FS at a rate of 1,5 l/ha, and for effective weed control in winter barley crops, spray with herbicide Caliber 75 c. g. + South Africa Trend 90 at a rate of 50 g/ha + 0,2 l/ha, which helps reduce weeds to 96,5% and will allow to obtain a grain yield of winter barley at 6,24 t/ha.