This study examined the impact of a tailored nutritional education program on dietary compliance and clinical outcomes in chronic kidney disease patients. The study included 440 participants who were randomly divided into an intervention group (n = 220), which received a customized nutritional education program and a control group (n = 220), which received standard treatment without additional dietary supervision. The educational intervention, designed to address key dietary adjustments, was delivered through individual and group sessions, with monthly follow-ups and instructional materials in print and digital formats. Nutrient intake was closely monitored, particularly potassium, phosphate, and protein intake. Clinical outcomes such as serum creatinine levels, glomerular filtration rate, blood pressure, and electrolyte levels were measured at baseline and at six months after the intervention. Dietary compliance was assessed using a validated questionnaire. Results indicated significant improvements in dietary compliance in the intervention group, with notable reductions in potassium and phosphate intake compared to the control group. The intervention group also demonstrated better protein regulation. These changes in nutrient intake were associated with improvements in clinical outcomes, including enhanced glomerular filtration rate, stabilized serum creatinine levels, and improved blood pressure control. These findings suggest that tailored nutritional education programs can significantly enhance dietary adherence and improve clinical outcomes in chronic kidney disease patients, highlighting the importance of personalized dietary interventions in managing chronic conditions.