Autocatalytic fission–fusion microexplosions, mutually amplifying fission and fusion reactions, are proposed for propulsion. Autocatalytic fission–fusion microexplosions can be realized by imploding a shell of uranium 235 (or plutonium) onto a magnetized deuterium–tritium (DT) plasma. After having reached a high temperature, the DT plasma releases fusion neutrons making fission reactions in the fissile shell increasing the implosion velocity which in turn increases the fusion reaction rate until full ignition of the DT plasma. To implode the fissile shell a small amount of high explosive and to magnetize the DT plasma a small auxiliary electric discharge are required. In comparison to nuclear bomb pulse propulsion, the energy released per pulse is much smaller and the efficiency higher. And in comparison to laser- or particle-beam-ignited fusion microexplosions, there is no need for a massive fusion ignition driver.