The ENBIS-21 Quality and Reliability Engineering International Special Issue is related to the contributions to the 21st Annual Conference of the European Network for Business and Industrial Statistics (ENBIS) held online from 13 to 15 September, 2021. The topics covered by the 12 papers included in this special issue fall within the scope of ENBIS, whose ultimate goal is to bridge the gap between methodology and application in the field of business and industrial statistics and foster networking between statisticians in academic and commercial settings. It becomes evident from the papers on this issue that classical methods of industrial statistics are still having a wide range of applications and expansions towards complex and big data structures as well as they are increasingly cross-fertilized by artificial intelligence and machine learning perspectives and approaches. The issue is opened by the contribution of Yang et al.1 in the Statistical Process Monitoring (SPM) of data in the form of tensors. The authors develop a hierarchical in-situ process monitoring approach for anomaly detection, which is applied to thermal video streams acquired during a metal additive manufacturing process for highly complex parts. A more traditional SPM approach based on generalized likelihood ratio (GLR) control charts is elaborated by Rizzo and Di Bucchianico2 to set up tailor-made monitoring for high-purity (high-quality) processes and deals with issues arising in GLR control charts for discrete processes. Along the line of developing statistical methods for complex data structures, Gril et al.3 set up a tensor-on-tensor regression model able to dynamically predict repetitive human motions helpful in avoiding unwanted collisions at the interface with robots in industrial assembly tasks. Chuquin et al.4 present a straightforward extension of the K-means clustering to spatially correlated functional data, with an application in the analysis of the normalized difference vegetation index in a large region of Ecuador. From a more general perspective, Vanacore et al.5 address the problem of assessing prediction performance in the multi-class classification of imbalanced data sets. In the optimal Design of Experiments (DoE) Pesce et al.6 offer new results that are oriented to bias reduction in large datasets and protection against confounders. Whereas, Kirchhoff et al.7 use DoE as the initial solution for the optimization of shift planning in high-bay warehouse operations based on Gaussian process models with low-rank correlation kernels. Risk assessment and management is the topic of the following three papers. Testik and Unlu8 compare traditional and fuzzy failure modes and effect analysis to rank risks in different areas of testing and calibration laboratories. Meynaoui et al.9 deal with an accidental scenario in a sodium-cooled fast nuclear reactor by means of a global sensitivity analysis of the input parameter distribution used in numerical simulator outputs to model physical phenomena. Lai and Zwetsloot10 offer a data-driven ensemble ranking system of product quality, which is validated in the identification of high-risk manufacturers in a solar industry case study. The final two papers are devoted to the Reliability and Maintenance of repairable systems. El-Aroui and Gaudoin11 propose a general goodness-of-fit test for imperfect repair models that has the favorable property of being asymptotically distribution-free for renewal and power law processes. Fouladirad et al.12 develop a new bounded transformed gamma process model to describe and predict degradation phenomena by relaxing the typical assumption that the degradation level can grow indefinitely, which is often unrealistic for technological units. The proposed model is also applied to a set of wear measures of cylinder liners that equip a diesel engine for marine propulsion. We are deeply grateful to the journal staff for their professional assistance in the editorial process, as well as to the anonymous referees for the time and effort spent to provide careful and constructive comments, and to all the authors, who made revisions on a very tight timescale.