Impact Of COVID-19 Research Articles

Architectural organization and in situ fusion protein structure of lymphocytic choriomeningitis virus.

The impact of COVID-19 on public health has highlighted the importance of understanding zoonotic pathogens. Lymphocytic choriomeningitis virus (LCMV) is a rodent-borne human pathogen that causes hemorrhagic fever. Herein, we describe the in situ structure of LCMV proteins and their architectural organization on the viral envelope and around the nucleocapsid. The virion structure reveals the distribution of the surface glycoprotein complex (GPC) and the contact points between the viral envelope and the underlying matrix protein, as well as the association with the nucleocapsid. The morphology and sizes of virions, as well as the number of RNA polymerase L inside each virion vary greatly, highlighting the fast-changing nature of LCMV. A comparison between the in situ GPC trimeric structure and prior ectodomain structures identifies the transmembrane and endo domains of GPC and key interactions among its subunits. The work provides new insights into LCMV assembly and informs future structure-guided vaccine design.

The impact of Covid-19 on recovery after sexual violence and abuse: Voices of help-seeking survivors and those individuals working within specialist support services in England

We examined the impact of Covid-19 on service delivery within specialist sexual violence services and the healing journeys of survivors of sexual violence and abuse through the experiences of 22 professionals and 221 service users in England. The pandemic posed challenges across all sectors and economies across the globe, but practices and innovations that emerged at that time could enhance future services and user experiences. Thematic analysis was used to identify key themes within the data. Overall, the negative impacts of Covid-19 outweighed the positive changes: survivors reported increased feelings of depression, anxiety, and worry, exacerbated by isolation and lost connections with friends and family, and access to strategies for managing their mental health. Difficulties/delays in accessing support, service provision, and disruptions to rapport, trust, and safety were widespread in participants’ reports. Conversely, for some, requirements to remain at home provided safety from the world, and space for healing, and even prompted survivors of non-recent abuse to seek help. Remote service delivery was beneficial where clients could be ‘at a distance’ in discussing sensitive issues. Together with insights from professionals about their own isolation, blurred boundaries, and concerns regarding client confidentiality and engagement, this research highlights an agile sector responding to an unprecedented situation. Moving forward, survivors’ preferences for flexible/remote support must be integrated into everyday delivery.

Adolescents’ physical activity during and beyond the Covid-19 pandemic: a qualitative study exploring the experiences of young people living in the context of socioeconomic deprivation

BackgroundAdolescent physical activity levels are low and are shown to decline with age into adulthood. Emerging literature suggests these trends were exacerbated during the Covid-19 pandemic. We aimed to understand, from the perspective of adolescents living in deprived communities, whether the Covid-19 pandemic influenced their physical behaviour and explore their ideas for physical activity promotion moving forward.MethodsPurposive sampling was used to recruit older adolescents (13-18-year-old) living in one of the 20% most deprived areas in the UK, as defined by the UK Index of Multiple Deprivation. A mix of in-person and online one-to-one semi-structured interviews were conducted between July 2021- March 2022. Interviews were audio-recorded, transcribed verbatim and anonymised. Data were imported into Nvivo software and analysed drawing on Braun and Clarke’s six phases of thematic analysis.ResultsThe sample consisted of 16 adolescents and included a mix of genders. The following themes were generated during the data analysis: (1) Physical activity behaviour in everyday life (prepandemic), (2) The impact of Covid-19 on physical activity (during) and (3) Young people’s ideas about physical activity promotion (moving forward). Participants described themselves as inactive, with their activity limited to active travel, informal activity and physical education. Experiences of the pandemic were largely negative, impacting participants’ physical and mental health. Ideas around physical activity promotion ranged from the individual to the societal level.ConclusionsOur findings suggest the Covid-19 pandemic had a major impact on young people living in the context of socioeconomic deprivation. Physical activity promotion efforts should focus on school-based opportunities and the provision of safe and low-cost opportunities in socioeconomically deprived areas. As we aim to build back from the Covid-19 pandemic, supporting young people living in socioeconomically deprived communities should be prioritised.

Endocrine dysregulation in COVID-19: molecular mechanisms and insights.

This review describes the impact of COVID-19 on the endocrine system, focusing on cortisol signaling and growth factor-induced endocrine resistance. As expected, SARS-CoV-2 infection induces systemic inflammation, resulting in stimulation of the adrenal glands leading to elevated cortisol levels with normal adrenocorticotropic hormone (ACTH) levels. The cytokine storm could also stimulate cortisol production. However, in some instances, cortisol levels rise independently of ACTH due to a phenomenon known as "pseudo-Cushing's syndrome," where adrenal glands become less responsive to ACTH. Plasma proteomic analyses showed that this pattern was variably observed among COVID-19 patients, potentially involving calcium dysregulation and GNAS-regulated activities, ultimately impacting the regulation of microvascular permeability. COVID-19 also exhibited a syndrome resembling endocrine resistance, governed by receptor tyrosine kinase signaling pathways. Mild cases displayed elevated activity of EGFR and MMP9, along with increased expression of survival factors like Bax and Bcl2. In contrast, more severe cases involved IGFR-I and enhanced NOTCH signaling, with altered expression of Bcl2, AKT1, and MAPK8. In summary, these findings describe the complex interplay between COVID-19 and endocrine pathology, particularly endocrine resistance. These insights suggest potential endocrine targets for therapeutic interventions to improve short- and long-term outcomes for COVID-19 patients.

Gender and race disparities in the evaluation of COVID-19 impact statements for tenure and promotion candidates

ABSTRACT The COVID-19 pandemic disrupted research productivity for many faculty members. As a result, many US universities began asking promotion and tenure candidates to create COVID-19 impact statements in hopes of mitigating the negative impact of these disruptions on tenure decisions. However, little is known about how such impact statements might be evaluated by promotion and tenure committees. This study examined whether such statements might be evaluated differently based on the gender and racial/ethnic categories of the faculty that submit them. Specifically, current US faculty were asked to evaluate hypothetical tenure dossiers that varied in race/ethnicity (Black/Latinx/White) and binary gender (Male/Female). Results indicated that female candidates were evaluated more favorably than male candidates. Specifically, participants thought that female candidate’s disruptions were more understandable, that their COVID-19 impact statements should be given more weight, and that they were more likely to vote to promote female candidates. There were no significant differences across candidates by race/ethnicity. The unexpected pattern of results suggests more research is needed to understand why such patterns emerged.

Impact of COVID-19 on the tourism industry in the northeastern region of Bangladesh

Impact of COVID-19 on the tourism industry in the northeastern region of Bangladesh

Study on Spatiotemporal Characteristics and Influencing Factors of High-Resolution Single-Season Rice

Single-season rice describes the area under rice cultivation from May–October of the year. Many scholars have used lower-resolution data to study single-season rice in different regions, but using high-precision and high-resolution single-season rice data can reveal new phenomena. This paper uses a long-time-series, high-precision, and high-resolution single-season rice cultivation dataset to conduct an in-depth analysis of the spatial–temporal variability characteristics of single-season rice in Jiangsu Province, China, from 2017 to 2021. It explores the correlation between meteorological factors and greenhouse gasses for single-season rice. It analyzes the driving role of social factors on single-season rice. The results showed that single-season rice was mainly grown in the central and northeastern regions of the study area. The single-season rice cultivation was significantly reduced in 2020 due to the impact of COVID-19. Single-season rice strongly correlates with meteorological factors in time but shows a weak spatial correlation. This is because human factors largely dominate the area under single-season rice cultivation. Methane emissions in the study area are mainly influenced by anthropogenic activities rather than single-season rice. Social factors are essential in controlling single-season rice cultivation in the study area. This study was conducted in Jiangsu Province, China. Still, the methodology and results have important implications for agricultural production and environmental management studies in other regions, and some findings have general applicability.

The Impact of COVID-19 on Corporate Governance Practices and Legal Requirements

The COVID-19 pandemic has had an unprecedented effect on businesses worldwide, exposing vulnerabilities in corporate governance and challenging existing legal frameworks. This research paper examines the impact of the pandemic on corporate governance practices, focusing on the adaptations made by businesses to maintain operational integrity, ensure compliance, and protect stakeholder interests. It also explores the legal requirements and reforms that have been implemented to accommodate new challenges, including virtual board meetings, increased disclosure obligations, and enhanced attention to environmental, social, and governance (ESG) factors. The paper concludes with an analysis of the long-term implications of these changes, arguing that COVID-19 has accelerated trends toward greater transparency, flexibility, and stakeholder engagement in corporate governance.

Impacts of the COVID-19 pandemic on the experiences of incarcerated pregnant people

BackgroundThe COVID-19 pandemic disproportionately impacted incarcerated populations, yet few studies have investigated the specific effects on incarcerated pregnant people. This study compares pregnant people’s experiences of pregnancy and parenting in prison before and during the pandemic in order to explore the impacts of COVID-19 on this population.MethodsWe conducted semi-structured interviews with pregnant people at a state prison as part of a larger study on pregnant people’s experiences during incarceration. Interviews explored participants’ experiences and decision-making related to pregnancy and parenting while incarcerated. This secondary analysis compared interviews conducted between June 2019 and March 2020 (pre-COVID-19) to interviews conducted between June and November 2020 (during COVID-19). Interviews conducted during the pandemic included questions about the impact of COVID-19 on participants’ experiences. Brief three and six-month follow-up interviews were conducted when possible.ResultsCOVID-19 introduced new stressors and exacerbated preexisting stressors around participants’ reproductive and parenting experiences. Three major themes emerged: 1) incarceration causes mental, emotional, and physical distress during pregnancy and parenting; 2) COVID-19 worsened conditions of incarceration, contributing to participants’ distress; and 3) the introduction of quarantine protocols during the pandemic felt uniquely punitive for pregnant and postpartum people.ConclusionsThe COVID-19 pandemic was characterized as a major crisis and primary threat to public health, particularly for incarcerated individuals. Yet just as COVID-19 exacerbated preexisting disparities for marginalized, non-incarcerated communities, incarcerated pregnant people similarly described a “worsening” of already-intolerable conditions. The indiscriminate application of quarantine protocols for pregnant people reflects broader carceral logics of control that do not account for the wellbeing of pregnant and postpartum people and their infants, as evidenced by current practices of infant separation, a lack of support, and physically taxing living conditions.

The impact of COVID-19 and the ERS on superannuation savings in Australia

COVID-19 has had a significant economic impact on Australia, and consequently on the superannuation savings of many individuals. To examine COVID-19’s heterogeneous effects across different industries and demographic groups, the impact on superannuation was assessed for 12 representative cameos using a range of Australian data, including Household, Income and Labour Dynamics in Australia (HILDA), ATO, ABS and APRA sources. The marginal impacts of sudden job loss, investment losses, investment switching and participation in the Early Release of Superannuation (ERS) scheme were each investigated in turn. The cameos highlight that some demographic cohorts faced several compounding challenges. For example, many ERS applicants were already facing financial hardship, were more likely to be younger, and faced a higher risk of unemployment. This highlights that COVID-19 has impacted different cohorts in different ways, depending on age, employment status and industry, and family situation, among other factors. JEL Classification: D14, D15, J26, J32

Evaluation of Mortality Statistics in Turkey from 2017 to 2022: An Analysis of the Impact of COVID-19.

Examining death statistics at regular intervals is highly useful for assessing public health. This study aimed to analyze cause-specific mortality statistics, to ascertain their distribution over the years, and to offer remedial solutions to enhance public health outcomes. In this retrospective descriptive study, an analysis was conducted on data sourced from the "Death and Cause of Death Statistics" provided by the Turkish Statistical Institute between 2017 and 2022. While the crude mortality rate remained stable from 2017 to 2019, a discernible increase in mortality rates has been observed since 2020, attributed to the impact of the pandemic. The crude death rate was the highest in the <5 yr and ≥65 yr age groups. Approximately 70% of the total mortality cases in Turkey were attributed to cardiovascular diseases, cancers, respiratory diseases, and diabetes. Given the world's rapidly aging population, an increase in deaths related to the four major noncommunicable diseases is foreseen. Therefore, there is an imperative need to enhance efforts aimed at preventing and controlling these diseases.

Navigating Inflationary Tides: An In-Depth Exploration of Inflation’s Impact on the Indian Economy and Strategic Approaches for Mitigation

Inflation occurs when the value of a currency diminishes over time, making it more expensive to buy the same goods and services than it was in the past. Imagine you&amp;apos;re shopping for your daily essentials like groceries, fuel, or even clothing. Over time, you might notice that the prices of these items have gone up, meaning your money doesn&amp;apos;t stretch as far as it used to. This rise in prices across a broad range of products is what we call inflation. At its core, inflation is driven by an imbalance where the money supply grows faster than the goods and services available. When there&amp;apos;s more money floating around but the same amount of goods, people are willing to pay more for these goods, leading to higher prices. It&amp;apos;s like an auction where more bidders show up, driving up the price of the item being sold. For India, the International Monetary Fund (IMF) has pointed out that even though the economy is bouncing back after the impact of COVID-19, there&amp;apos;s a risk of rising inflation. The IMF suggests that as the recovery strengthens, India should slowly reduce the monetary policies that were supporting the economy during the downturn. One of the most effective tools central banks have to control inflation is adjusting interest rates. By raising interest rates, it becomes more expensive to borrow money, which slows down spending and investment, helping to cool off inflation.

The impact of COVID- 19 on Primary and Secondary Schooling in Mogadishu

Background: Since December 2019, the COVID – 19 pandemic has been circulating in Somalia and other areas of the country. The disease has had a global impact on social, physical, psychological, and educational systems. The study examines how the COVID-19 pandemic impacted the educational process in Mogadishu, Somalia's primary and secondary schools. Aim: This study aims to explore the effect of COVID – 19 on Primary and Secondary Schooling in Mogadishu - Somalia. Methods: This study used a descriptive quantitative analysis design and was performed in a random sample of primary and secondary schools in Mogadishu. The survey data was obtained from 329 schools representing 274 head teachers. A self-administered questionnaire was used to gather information about the head teacher, including background information, activity, and student information. Findings: During the coronavirus, the most of the head teachers were concerned and stressed. The study also showed that the majority of schools are private and rent, that school income is dependent on student tuition, and that school income has declined as a result of the pandemic outbreak, and that the majority of schools have not obtained any financial aid from the government. Conclusion: The principals have learned a valuable lesson that they will apply in the future when dealing with unforeseen circumstances.

Prevalence, Risk Factors, and Impact of Long COVID Among Adults in South Korea.

This study aimed to identify the prevalence, risk factors, and impact of long COVID in a community-based representative sample of patients with COVID-19 aged 19-64 years. A total of 975 participants completed online or telephone surveys at 1 and 3 months post-diagnosis, covering persistent symptoms, daily activity limitations, vaccination status, and underlying diseases. Long COVID, as defined by the WHO criteria, had a prevalence of 19.7-24.9% in females and 12.7% in males. Logistic regression revealed that the odds of having long COVID symptoms were higher among females compared to males (OR, 2.43; 95% CI, 1.53-3.87), and higher in those aged ≥ 30 years compared to those aged 19-29 years: 30-39 years (OR, 2.91; 95% CI, 1.59-5.33), 40-49 years (OR, 2.72; 95% CI, 1.51-4.89), and 50-64 years (OR, 1.96; 95% CI, 1.10-3.49). Additionally, patients with underlying diseases had higher odds of long COVID symptoms compared to those without underlying diseases (OR, 1.81; 95% CI, 1.24-2.64). Among those with long COVID, 54.2% experienced daily activity limitations, and 40.6% received treatment. Furthermore, lower income groups faced greater daily activity limitations but had similar treatment rates to higher income groups. These findings emphasize the need for interest in and the development of programs to support these low-income populations.

Pandemic scars: long-term impact of COVID-19 on work stress among healthcare workers in China.

This study mainly focused on the long-term effect of different risk exposure levels and prior anti-epidemic experience of healthcare workers in mitigating COVID-19 on their work stress in the post-COVID era. The study sample included 359 physicians, 619 nurses, 229 technicians and 212 administrators, for a total of 1,419 healthcare workers working in the Lanzhou area during the investigation. Data were analyzed by multivariate regression models. Our findings indicated that the interaction between pandemic effect mitigation experience and high-risk exposure significantly affected healthcare workers in the post-COVID era by increasing their work stress (p<0.001) and reducing their rest time (p<0.001). Healthcare workers may have experienced worse outcomes in the long term if they had higher levels of risk exposure and more experience in fighting epidemics. Furthermore, poor mental health (p<0.001) and prior experience with SARS (p<0.001) further amplified these adverse effects. However, surprisingly, we did not observe any effect of prior anti-epidemic experience or high-risk exposure on the mental health of healthcare workers in the post-COVID era (p>0.1). The adverse impact of COVID-19 may have left long-lasting effects on Health professionals (HPs), particularly those with high Risk exposure (RE) and more mitigation experience. Poor Mental health (MH) and previous experience in mitigating previous similar outbreaks (such as SARS) are risk factors that should be considered. Support programs must be designed and promoted to help HPs respond and improve their performance. Our study presents compelling evidence that the COVID-19 pandemic will have long-term detrimental effects on the work stress of healthcare workers.

Analyzing the Impact of COVID-19 on Travel and Search Distances for Prominent Landmarks: Insights from Google Trends, X, and Tripadvisor

Analyzing the Impact of COVID-19 on Travel and Search Distances for Prominent Landmarks: Insights from Google Trends, X, and Tripadvisor

Navigating the global health seas: A personal odyssey through the depths of COVID-19

This study offers an extensive perspective on the COVID-19 pandemic through a unique lens, blending personal narratives with informative analysis. Owing to strained public health systems, individuals faced emblematic struggles &amp;ndash; such as awaiting medical attention in overwhelmed emergency rooms and securing testing appointments&amp;ndash;which symbolized universal experiences. Through depersonalized yet interconnected stories, this study elucidates systemic vulnerabilities in global health infrastructures. An examination of socioeconomic disparities through third-person narratives reveals communities grappling with layoffs and limited health-care access. This study seeks to offer an analytical yet empathetic exploration of the broader socioeconomic impact of COVID-19. The objective portrayal of the pursuit for equitable vaccine access mirrors global challenges in scheduling and supply shortages. Furthermore, the personal narratives highlight the connections forged, the information shared, and the resources pooled, emphasizing a shared commitment to overcoming challenges together. This study concludes with a collective call for adopting a resilient, equitable, and united approach to global health in which informed perspectives of collective struggle converge for a better future.

The Unique Impacts of COVID-19 on Low-Income and Diverse Canadian Women's Mental Health Profiles: A Latent Transition Analysis.

There is evidence of an overall decline in women's mental health, particularly those with young children, in the wake of the COVID-19 pandemic. However, research has also found heterogeneity in women's mental health responses. This longitudinal study sampled low-income women with young children by recruiting from the government's child care financial subsidy waitlist. To examine heterogeneity in women's mental health responses to COVID-19, a latent transition analysis was employed to identify profiles of anxiety, depression, and stress among 289 low-income mothers. Using these identified profiles, we examined the transitional patterns between profiles before and during COVID-19 and the sociodemographic and familial factors related to these profiles. A three-profile solution was identified prior to COVID-19 and a four-profile solution during COVID-19, with some profiles exhibiting qualitatively different defining characteristics. Latent transition analyses found diverse patterns of mental health changes after the onset of COVID-19. Mothers with better mental health prior to COVID-19 tended to have the most stable mental health during COVID-19. In contrast, mothers who were highly stressed prior to COVID-19 were equally likely to improve or decline after the onset of the pandemic. In addition, the relationships between race, parenting practices, child temperament, and child mental health were significantly related to mothers' mental health profiles. These findings describe mothers' experiences and areas where policymakers and practitioners can tailor support to low-income women with young children.

Impact of COVID-19 on women leadership in Saudi higher education institutions

The COVID-19 epidemic caused unexpected complications, complexities and challenges in higher educational institutions (HEIs). In order to promote and strengthen the role of women leadership, this study aimed to clarify the unique challenges faced by female leaders at Saudi HEIs during the epidemic, find possible solutions to these challenges, and provide policy as well as management implications. A systematic literature review (SLR) was conducted, examining 27 records (i.e., research papers, articles and conference studies). The data were qualitatively analysed and categorized based on themes like challenges faced, opportunities recognized, and solutions proposed. Findings highlighted women leaders in Saudi HEIs grappled with multiple challenges, including technological barriers, cultural constraints, and increased workloads. Merging challenges with solvable strategies offers a forward-looking perspective, advocating for systemic changes that can shape a resilient and inclusive future for HEIs in Saudi Arabia.

Effects of the COVID-19 pandemic on hospital admissions and inpatient mortality in Kenya: a retrospective cohort study

Background The impact of COVID-19 in Africa remains poorly described. We examined hospitalisation trends for all medical causes, clinician-diagnosed pneumonia admissions, and inpatient mortality in Kenya two years before and across the first six waves of the pandemic. Methods We conducted a hospital-based observational study of patients admitted to 13 public referral facilities in Kenya from January 2018 to December 2022. The pre-COVID-19 population included admissions before 1st March 2020. Time series models, adjusted for seasonality and hospital, compared observed and predicted trends. To estimate the impact of the COVID-19 pandemic, we calculated incidence rate ratios (IRR) from negative binomial mixed-effects models. Results 357,631 patients were admitted across the 13 sites (range 15,354 to 67,241 per hospital). 45,349 patients (42.1%) were admitted to the adult medical wards. On the paediatric ward, 163,608 individuals (47.4%) were aged under five years and 36,227 individuals (10.5%) were aged five years and older. In comparison to the pre-pandemic period, hospitalisations reduced for adults (IRR 0.75, 95% CI 0.69–0.82) and paediatric cases (IRR 0.69, 95% CI 0.64–0.75). In-hospital deaths also declined for adults (IRR 0.83, 95% CI 0.77–0.89) and children (IRR 0.85, 95% CI 0.77–0.94). Adult pneumonia admissions increased (IRR 1.59, 95% CI 1.36–1.85), while paediatric cases decreased overall, (IRR 0.78, 95% CI 0.51–1.20), but became elevated in late 2021 compared to the pre-pandemic period. Conclusions The COVID-19 pandemic did not cause a surge in hospitalisations in Kenya. However, pneumonia admissions among adults (but not children) increased significantly, with peaks aligning with the pandemic waves. These findings underscore the importance of syndromic inpatient surveillance in detecting and monitoring outbreaks.