Pap Smear Images Research Articles

Comparison of deep transfer learning models for classification of cervical cancer from pap smear images

Cervical cancer is one of the most commonly diagnosed cancers worldwide, and it is particularly prevalent among women living in developing countries. Traditional classification algorithms often require segmentation and feature extraction techniques to detect cervical cancer. In contrast, convolutional neural networks (CNN) models require large datasets to reduce overfitting and poor generalization. Based on limited datasets, transfer learning was applied directly to pap smear images to perform a classification task. A comprehensive comparison of 16 pre-trained models (VGG16, VGG19, ResNet50, ResNet50V2, ResNet101, ResNet101V2, ResNet152, ResNet152V2, DenseNet121, DenseNet169, DenseNet201, MobileNet, XceptionNet, InceptionV3, and InceptionResNetV2) were carried out for cervical cancer classification by relying on the Herlev dataset and Sipakmed dataset. A comparison of the results revealed that ResNet50 achieved 95% accuracy both for 2-class classification and for 7-class classification using the Herlev dataset. Based on the Sipakmed dataset, VGG16 obtained an accuracy of 99.95% for 2-class and 5-class classification, DenseNet121 achieved an accuracy of 97.65% for 3-class classification. Our findings indicate that DTL models are suitable for automating cervical cancer screening, providing more accurate and efficient results than manual screening.

A Fine-Tuned Adaptive Weight Deep Dense Meta Stacked Transfer Learning Model for Effective Cervical Cancer Prediction

Abstract In the digital world of remarkable technological advancements, the detection of cervical cancer at early stages is of important clinical significance as it can vastly improve the survival rate during treatment. Cervical cytopathology, often known as a Pap test is the frequently adopted screening method for cervical cancer. However, the test seems to be effective but investigation of images containing Pap smear with the help of a microscope is a difficult as well as laborious exercise. The procedure for the same demands an expert in the area and is often time-consuming. The serious pitfalls in subjective clinical evaluation evoke the need of developing an automated system for more reliable cervical cancer diagnosis. Therefore, the goal of this study primarily focuses on designing a Deep learning model to process the Pap smear images and correctly classify the cervical cells. For this purpose, firstly, a publically available dataset namely SIPaKMeD is utilized. Then, different data pre-processing methods are applied to intensify the data quality for effective analysis. Next, a novel stacking model is proposed that leverages a Support Vector Classifier (SVC) as a Meta model over a combination of different Transfer Learning Models including VGG16, ResNet101, InceptionV3, Xception, DenseNet169, and Inception ResNet. Furthermore, the dense layers are added to tune the underlying base transfer learning models to learn fine-tuned adaptive weights. The results obtained from experimental evaluation demonstrate the efficacy of the proposed stacking model by yielding the highest accuracy rate of 95.66% in comparison to other employed methods and existing state-of-the-art techniques.

BMT: A Cross-Validated ThinPrep Pap Cervical Cytology Dataset for Machine Learning Model Training and Validation

In the past several years, a few cervical Pap smear datasets have been published for use in clinical training. However, most publicly available datasets consist of pre-segmented single cell images, contain on-image annotations that must be manually edited out, or are prepared using the conventional Pap smear method. Multicellular liquid Pap image datasets are a more accurate reflection of current cervical screening techniques. While a multicellular liquid SurePath™ dataset has been created, machine learning models struggle to classify a test image set when it is prepared differently from the training set due to visual differences. Therefore, this dataset of multicellular Pap smear images prepared with the more common ThinPrep® protocol is presented as a helpful resource for training and testing artificial intelligence models, particularly for future application in cervical dysplasia diagnosis. The “Brown Multicellular ThinPrep” (BMT) dataset is the first publicly available multicellular ThinPrep® dataset, consisting of 600 clinically vetted images collected from 180 Pap smear slides from 180 patients, classified into three key diagnostic categories.

Multi-scale contextual learning for medical image segmentation via dual distillation.

Recently, many studies have explored fusing features extracted from Convolutional neural networks (CNNs) and transformers to integrate multi-scale representations for better performance in medical image segmentation tasks. Although these hybrid models have achieved better results than previous CNN-based and transformer-based methods, they suffer from high computation and spacecomplexities. The purpose of this research is to address the prohibitive computation and space complexities of hybrid models, which limit their application in clinical practice where computational resources are usuallyconstrained. We propose a novel model equipped with a dual distillation scheme to sufficiently harness the complementary advantages of CNNs and transformers without compromising model efficiency. We further propose a multi-scale prior-knowledge distillation (MPD) module to effectively distill multi-scale knowledge from features extracted from transformers. In addition, to cooperate with the knowledge distillation scheme, we also propose an efficient and robust Selective Fusion module in the studentnetwork. We extensively evaluate the proposed model against fourteen different network frameworks on two representative datasets: SipakMed and ISIC 2017. In the SipakMed dataset, 3037 Pap smear images are used for training and 1012 for testing. In the ISIC 2017 dataset, 2000 dermoscopic images are used for training, 150 for validation, and 600 for testing. Experimental results demonstrate that our method not only surpasses existing methods by a considerable margin with respect to the evaluation metrics of mean Intersection over Union, mean Dice coefficient, mean average symmetric surface distance, but also requires fewer computational resources in terms of model parameters and floating-point operations persecond. Comprehensive comparisons in terms of segmentation accuracy and computational complexity unequivocally confirm that our method effectively and efficiently integrates the advantages of both CNNs and transformers, showing its suitability and significance for clinicalapplications.

Optimizing cervical cancer classification using transfer learning with deep gaussian processes and support vector machines

BackgroundCervical cancer is the fourth most frequent cancer in women worldwide. Even though cervical cancer deaths have decreased significantly in Western countries, low and middle-income countries account for nearly 90% of cervical cancer deaths. While Western countries are leveraging the powers of artificial intelligence (AI) in the health sector, most countries in sub-Saharan Africa are still lagging. In Uganda, cytologists manually analyze Pap smear images for the detection of cervical cancer, a process that is highly subjective, slow, and tedious. Machine learning (ML) algorithms have been used in the automated classification of cervical cancer. However, most of the MLs have overfitting limitations which limits their deployment, especially in the health sector where accurate predictions are needed.MethodsIn this study, we propose two kernel-based algorithms for automated detection of cervical cancer. These algorithms are (1) an optimized support vector machine (SVM), and (2) a deep Gaussian Process (DGP) model. The SVM model proposed uses an optimized radial basis kernel while the DGP model uses a hybrid kernel of periodic and local periodic kernel.ResultsExperimental results revealed accuracy of 100% and 99.48% for an optimized SVM model and DGP model respectively. Results on precision, recall, and F1 score were also reported.ConclusionsThe proposed models performed well on cervical cancer detection and classification, and therefore suitable for deployment. We plan to deploy our proposed models in a mobile application-based tool. The limitation of the study was the lack of access to high-performance computational resources.

Enhancing pap smear image classification: integrating transfer learning and attention mechanisms for improved detection of cervical abnormalities

Cervical cancer remains a major global health challenge, accounting for significant morbidity and mortality among women. Early detection through screening, such as Pap smear tests, is crucial for effective treatment and improved patient outcomes. However, traditional manual analysis of Pap smear images is labor-intensive, subject to human error, and requires extensive expertise. To address these challenges, automated approaches using deep learning techniques have been increasingly explored, offering the potential for enhanced diagnostic accuracy and efficiency. This research focuses on improving cervical cancer detection from Pap smear images using advanced deep-learning techniques. Specifically, we aim to enhance classification performance by leveraging Transfer Learning (TL) combined with an attention mechanism, supplemented by effective preprocessing techniques. Our preprocessing pipeline includes image normalization, resizing, and the application of Histogram of Oriented Gradients (HOG), all of which contribute to better feature extraction and improved model performance. The dataset used in this study is the Mendeley Liquid-Based Cytology (LBC) dataset, which provides a comprehensive collection of cervical cytology images annotated by expert cytopathologists. Initial experiments with the ResNet model on raw data yielded an accuracy of 63.95%. However, by applying our preprocessing techniques and integrating an attention mechanism, the accuracy of the ResNet model increased dramatically to 96.74%. Further, the Xception model, known for its superior feature extraction capabilities, achieved the best performance with an accuracy of 98.95%, along with high precision (0.97), recall (0.99), and F1-Score (0.98) on preprocessed data with an attention mechanism. These results underscore the effectiveness of combining preprocessing techniques, TL, and attention mechanisms to significantly enhance the performance of automated cervical cancer detection systems. Our findings demonstrate the potential of these advanced techniques to provide reliable, accurate, and efficient diagnostic tools, which could greatly benefit clinical practice and improve patient outcomes in cervical cancer screening.

Classification of cervical cells from the Pap smear image using the RES_DCGAN data augmentation and ResNet50V2 with self-attention architecture

Cervical cancer is a type of cancer in which abnormal cell growth occurs on the surface lining of the cervix. In this study, we propose a novel residual deep convolutional generative adversarial network (RES_DCGAN) for data augmentation and ResNet50V2 self-attention method to classify cervical cells, to improve the generalizability and performance of the model. The proposed method involves adding residual blocks in the generator of the DCGAN to enhance data flow and generate higher-quality images. Subsequently, a self-attention mechanism is incorporated at the top of the pre-trained models to allow the model to focus more on significant features of the input data. To evaluate our approach, we utilized the Pomeranian and SIPaKMeD cervical cell imaging datasets. The results demonstrate superior performance, achieving an accuracy of 98% with Xception and 96.4% with ResNet50V2 on the Pomeranian dataset. Additionally, DenseNet121 with self-attention achieved accuracies of 92% and 95% in multiclass and binary classification, respectively, using the SIPaKMeD dataset. In conclusion, our RES_DCGAN-based data augmentation and pre-trained with self-attention model yields a promising result in the classification of cervical cancer cells.

Machine Learning-based Automated Diagnosis for Cervical Cancer Using Pap Smear Images: A Systematic Review

Machine Learning-based Automated Diagnosis for Cervical Cancer Using Pap Smear Images: A Systematic Review

New insight in cervical cancer diagnosis using convolution neural network architecture

<p>The Pap smear is a screening method for early cervical cancer diagnosis. The selection of the right optimizer in the convolutional neural network (CNN) model is key to the success of the CNN in image classification, including the classification of cervical cancer Pap smear images. In this study, stochastic gradient descent (SGD), root mean square propagation (RMSprop), Adam, AdaGrad, AdaDelta, Adamax, and Nadam optimizers were used to classify cervical cancer Pap smear images from the SipakMed dataset. Resnet-18, Resnet-34, and VGG-16 are the CNN architectures used in this study, and each architecture uses a transfer-learning model. Based on the test results, we conclude that the transfer learning model performs better on all CNNs and optimization techniques and that in the transfer learning model, the optimization has little influence on the training of the model. Adamax, with accuracy values of 72.8% and 66.8%, had the best accuracy for the VGG-16 and Resnet-18 architectures, respectively. Resnet-34 had 54.0%. This is 0.034% lower than Nadam. Overall, Adamax is a suitable optimizer for CNN in cervical cancer classification on Resnet-18, Resnet-34, and VGG-16 architectures. This study provides new insights into the configuration of CNN models for Pap smear image analysis.</p>

Classification of single-cell routine Pap smear images based on deep learning algorithms

In this study, we classified single-cell routine Pap smear images by applying deep learning algorithms such as AlexNet, VggNet, GoogleNet and MobileNet and compared their classification effects. The results show that the loss of all four models on both the training and test sets shows a trend of gradually decreasing and stabilising. Specifically, the loss of AlexNet gradually decreases from 0.637 to 0.212, VggNet from 0.777 to 0.278, GoogleNet from 1.77 to 0.31, and MobileNet from 0.809 to 0.267. At the same time, MobileNet exhibits the highest maximum and average accuracies which reached 93.9% and 88.3%, respectively, followed by GoogleNet model with 92.9% and 88.0%, AlexNet with 92% and 88.0%, and VggNet with 90.1% and 86.7%. The results show that MobileNet exhibits superior classification results in this task, which provides strong support for its potential application in the classification of single-cell routine Pap smear images. These findings are of great significance for further exploring the application of deep learning in the field of medical imaging and provide a useful reference for future related research.

Classification of single-cell routine Pap smear images based on deep learning algorithms

In this study, we classified single-cell routine Pap smear images by applying deep learning algorithms such as AlexNet, VggNet, GoogleNet and MobileNet and compared their classification effects. The results show that the loss of all four models on both the training and test sets shows a trend of gradually decreasing and stabilising. Specifically, the loss of AlexNet gradually decreases from 0.637 to 0.212, VggNet from 0.777 to 0.278, GoogleNet from 1.77 to 0.31, and MobileNet from 0.809 to 0.267. At the same time, MobileNet exhibits the highest maximum and average accuracies which reached 93.9% and 88.3%, respectively, followed by GoogleNet model with 92.9% and 88.0%, AlexNet with 92% and 88.0%, and VggNet with 90.1% and 86.7%. The results show that MobileNet exhibits superior classification results in this task, which provides strong support for its potential application in the classification of single-cell routine Pap smear images. These findings are of great significance for further exploring the application of deep learning in the field of medical imaging and provide a useful reference for future related research.

CINNAMON-GUI: Revolutionizing Pap Smear Analysis with CNN-Based Digital Pathology Image Classification

Background Medical imaging has seen significant advancements through machine learning, particularly convolutional neural networks (CNNs). These technologies have transformed the analysis of pathological images, enhancing the accuracy of diagnosing and classifying cellular anomalies. Digital pathology methodologies, including image analysis, have improved cervical cancer diagnostics. However, existing commercial platforms are often costly and restrictive, limiting customization and scalability. Methods CINNAMON-GUI is an open-source digital pathology tool based on CNNs for classifying Pap smear images. Transitioning to a Shiny app in Python, it offers enhanced user interface and interactivity. The application supports dynamic web interactions, advanced features for image analysis, and state-of-the-art CNN models tailored for digital pathology. Key features include intuitive UI components, real-time image and plot generation, memory-efficient data handling, and robust training capabilities with customizable CNN architectures. The tool also integrates with Labelme for defining regions of interest and allows testing on external biospecimens. Results Model A (seed 42, 100 epochs) and Model B (same architecture with adjusted augmentation parameters) were compared. Model A stabilized with training accuracy around 0.88 and validation accuracy around 0.913. Model B showed improved performance with training accuracy around 0.91 and validation accuracy around 0.95. Feature mapping highlighted critical morphological aspects, improving classification accuracy. Model B reduced misclassification errors significantly compared to Model A. Conclusions CINNAMON-GUI demonstrates the potential of an open-source platform in digital pathology, providing transparency and collaborative opportunities. The tool enhances diagnostic accuracy through feature map analysis and optimized CNN training. Future development aims to extend its application to other cancer types, leveraging its dynamic and user-friendly interface for broader use in diagnostics.

A two-stream decision fusion network for cervical pap-smear image classification tasks

Deep learning, especially Convolution Neural Networks (CNNs), has demonstrated superior performance in image recognition and classification tasks. They make complex pattern recognition possible by extracting image features through layers of abstraction. However, despite the excellent performance of deep learning in general image classification, its limitations are becoming apparent in specific domains such as cervical cell medical image classification. This is because although the morphology of cervical cells varies between normal, diseased and cancerous, these differences are sometimes very small and difficult to capture. To solve this problem, we propose a two-stream feature fusion model comprising a manual feature branch, a deep feature branch, and a decision fusion module. Specifically, We process cervical cells through a modified DarkNet backbone network to extract deep features. In order to enhance the learning of deep features, we have devised scale convolution blocks to substitute the original convolution, termed Basic convolution blocks. The manual feature branch comprises a range of traditional features and is linked to a multilayer perceptron. Additionally, we design three decision feature channels trained from both manual and deep features to enhance the model performance in cervical cell classification. Our proposed model demonstrates superior performance when compared to state-of-the-art cervical cell classification models. We establish a 15-category 148762 cervical cytopathology image dataset (CCID). In addition, we additionally conducted experiments on the SIPaKMeD dataset. Numerous experiments show that our proposed model performs excellently compared to state-of-the-art classification models. The outcomes illustrate that our approach can significantly aid pathologists in accurately evaluating cervical smears.

Pixel-wise segmentation of cells in digitized Pap smear images

A simple and cheap way to recognize cervical cancer is using light microscopic analysis of Pap smear images. Training artificial intelligence-based systems becomes possible in this domain, e.g., to follow the European recommendation to screen negative smears to reduce false negative cases. The first step for such a process is segmenting the cells. A large and manually segmented dataset is required for this task, which can be used to train deep learning-based solutions. We describe a corresponding dataset with accurate manual segmentations for the enclosed cells. Altogether, the APACS23 (Annotated PAp smear images for Cell Segmentation 2023) dataset contains about 37 000 manually segmented cells and is separated into dedicated training and test parts, which could be used for an official benchmark of scientific investigations or a grand challenge.

A Systematic Literature Review: Performance Comparison of Edge Detection Operators in Medical Images

Medical images play a crucial role in the diagnosis of diseases. To make the diagnosis more accurate, the image should usually be enhanced first using image processing methods such as segmentation and edge detection stages. However, the complexity and noise that may arise in these images pose challenges in edge detection. Therefore, to portray the characteristics of edge detection operators, this research presents a systematic literature review of the performance of various edge detection operators in medical images, focusing on literature published between 2019 and 2023. After the selection process, 41 papers out of the initial 112 collected papers were chosen for further review. The study evaluates edge detection operators e.g., Canny, Sobel, Prewitt, Roberts, and Laplacian of Gaussian (LOG) on medical images such as X-rays, MRI, CT scans, ultrasound, Pap smears, and others. In the analysis, the accuracy, computational time, and response to noise of each operator are compared. The results indicate that despite longer computational times, Canny emerges as the most accurate operator, especially in Pap smear and CT scan images. The LOG operator offers high accuracy in MRI images with more efficient computational time. Evaluation of operator reliability against noise confirms the superiority of Canny. Furthermore, the future potential of edge detection in medical services is also reviewed. For instance, Canny, known for accurate and noise-resistant edges, enhances detection in complex CT-Scan and X-ray images. Meanwhile, LOG, handling artifacts with lower computational time, improves edge clarity in medical images. Potential applications include enhanced diagnosis, efficient patient monitoring, and improved image clarity in future medical services.

A Semantic Segmentation of Nucleus and Cytoplasm in Pap-smear Images using Modified U-Net Architecture

Pap-smear images can help early detection of cervical cancer, but the manual interpretation by a pathologist can be time-consuming and prone to human error. Semantic segmentation of the cell nucleus and cytoplasm plays an essential role in Pap smear image analysis for the detection of cervical cancer automatically. This study proposes a modified U-Net architecture by adding batch normalization to each convolution layer. Batch normalization aims to stabilize and accelerate the convergence of the model during training, thus overcoming the vanishing gradient problem. The modified U-Net model achieves high accuracy and low loss during the training process, indicating its ability to learn and recognize patterns in the data. The performance evaluation of the model resulted in 91.4 % accuracy, 79.9 % sensitivity, 87.7 % specificity, 81.7 % F1-score, and 83.7 % precision. The results show that the proposed modification of U-Net architecture with batch normalization improves the segmentation performance for cervical cancer cells in Pap smear images. However, improvement in architecture is still required to increase the ability to overcome overlapping areas between the nucleus, cytoplasm, and background.

HO-SsNF: heap optimizer-based self-systematized neural fuzzy approach for cervical cancer classification using pap smear images.

Cervical cancer is a significant concern for women, necessitating early detection and precise treatment. Conventional cytological methods often fall short in early diagnosis. The proposed innovative Heap Optimizer-based Self-Systematized Neural Fuzzy (HO-SsNF) method offers a viable solution. It utilizes HO-based segmentation, extracting features via Gray-Level Co-Occurrence Matrix (GLCM) and Local Binary Pattern (LBP). The proposed SsNF-based classifier achieves an impressive 99.6% accuracy in classifying cervical cancer cells, using the Herlev Pap Smear database. Comparative analyses underscore its superiority, establishing it as a valuable tool for precise cervical cancer detection. This algorithm has been seamlessly integrated into cervical cancer diagnosis centers, accessible through smartphone applications, with minimal resource demands. The resulting insights provide a foundation for advancing cancer prevention methods.

An efficient Fusion-Purification Network for Cervical pap-smear image classification

Background and Objectives:In cervical cell diagnostics, autonomous screening technology constitutes the foundation of automated diagnostic systems. Currently, numerous deep learning-based classification techniques have been successfully implemented in the analysis of cervical cell images, yielding favorable outcomes. Nevertheless, efficient discrimination of cervical cells continues to be challenging due to large intra-class and small inter-class variations. The key to dealing with this problem is to capture localized informative differences from cervical cell images and to represent discriminative features efficiently. Existing methods neglect the importance of global morphological information, resulting in inadequate feature representation capability. Methods:To address this limitation, we propose a novel cervical cell classification model that focuses on purified fusion information. Specifically, we first integrate the detailed texture information and morphological structure features, named cervical pathology information fusion. Second, in order to enhance the discrimination of cervical cell features and address the data redundancy and bias inherent after fusion, we design a cervical purification bottleneck module. This model strikes a balance between leveraging purified features and facilitating high-efficiency discrimination. Furthermore, we intend to unveil a more intricate cervical cell dataset: Cervical Cytopathology Image Dataset (CCID). Results:Extensive experiments on two real-world datasets show that our proposed model outperforms state-of-the-art cervical cell classification models. Conclusions:The results show that our method can well help pathologists to accurately evaluate cervical smears.

Ensemble and Transformer Encoder-based Models for the Cervical Cancer Classification Using Pap-smear Images

Cervical cancer poses a health concern for women globally ranking as the seventh most common disease and the fourth most frequent cancer among women. The classification of cytopathology images is utilized in diagnosing this condition with a focus on automating the process due to potential human errors in manual examinations. This study presents an approach that integrates transfer learning, ensemble learning and a transformer encoder to classify cervical cancer using pap-smear images from the SIPaKMeD dataset. By combining these methods human involvement in the classification task is minimized. Initially individual models based on transfer learning are. Their unique characteristics are combined to create an ensemble model. This ensemble model is then input into the proposed transformer encoder specifically utilizing the Vision Transformer (ViT) model. The results highlight the effectiveness of this methodology. The VGG16 model demonstrates accuracy of 97.04% and an F1 score of 97.06% when applied to classifying five categories using the SIPaKMeD dataset. However surpassing this performance is the learning model, with an accuracy of 97.37%. Notably outperforming all models is the transformer encoder model achieving an accuracy of 97.54%.Through the utilization of transfer learning, ensemble learning and the transformer encoder model this research introduces a method, for automating the classification of cervical cancer. The findings underscore the capability of the suggested approach to enhance the precision and effectiveness of diagnosing cancer.

Optimizing Cervical Cancer Classification with SVM and Improved Genetic Algorithm on Pap Smear Images

Optimizing Cervical Cancer Classification with SVM and Improved Genetic Algorithm on Pap Smear Images