Subset Of Images Research Articles

Effect of Image-Processing Routines on Geographic Object-Based Image Analysis for Mapping Glacier Surface Facies from Svalbard and the Himalayas

Advancements in remote sensing have led to the development of Geographic Object-Based Image Analysis (GEOBIA). This method of information extraction focuses on segregating correlated pixels into groups for easier classification. This is of excellent use in analyzing very-high-resolution (VHR) data. The application of GEOBIA for glacier surface mapping, however, necessitates multiple scales of segmentation and input of supportive ancillary data. The mapping of glacier surface facies presents a unique problem to GEOBIA on account of its separable but closely matching spectral characteristics and often disheveled surface. Debris cover can induce challenges and requires additions of slope, temperature, and short-wave infrared data as supplements to enable efficient mapping. Moreover, as the influence of atmospheric corrections and image sharpening can derive variations in the apparent surface reflectance, a robust analysis of the effects of these processing routines in a GEOBIA environment is lacking. The current study aims to investigate the impact of three atmospheric corrections, Dark Object Subtraction (DOS), Quick Atmospheric Correction (QUAC), and Fast Line-of-Sight Atmospheric Analysis of Hypercubes (FLAASH), and two pansharpening methods, viz., Gram–Schmidt (GS) and Hyperspherical Color Sharpening (HCS), on the classification of surface facies using GEOBIA. This analysis is performed on VHR WorldView-2 imagery of selected glaciers in Ny-Ålesund, Svalbard, and Chandra–Bhaga basin, Himalaya. The image subsets are segmented using multiresolution segmentation with constant parameters. Three rule sets are defined: rule set 1 utilizes only spectral information, rule set 2 contains only spatial and contextual features, and rule set 3 combines both spatial and spectral attributes. Rule set 3 performs the best across all processing schemes with the highest overall accuracy, followed by rule set 1 and lastly rule set 2. This trend is observed for every image subset. Among the atmospheric corrections, DOS displays consistent performance and is the most reliable, followed by QUAC and FLAASH. Pansharpening improved overall accuracy and GS performed better than HCS. The study reports robust segmentation parameters that may be transferable to other VHR-based glacier surface facies mapping applications. The rule sets are adjusted across the processing schemes to adjust to the change in spectral characteristics introduced by the varying routines. The results indicate that GEOBIA for glacier surface facies mapping may be less prone to the differences in spectral signatures introduced by different atmospheric corrections but may respond well to increasing spatial resolution. The study highlighted the role of spatial attributes for mapping fine features, and in combination with appropriate spectral features may enhance thematic classification.

Identifying Transient Candidates in the Dark Energy Survey Using Convolutional Neural Networks

The ability to discover new transient candidates via image differencing without direct human intervention is an important task in observational astronomy. For these kind of image classification problems, machine learning techniques such as Convolutional Neural Networks (CNNs) have shown remarkable success. In this work, we present the results of an automated transient candidate identification on images with CNNs for an extant data set from the Dark Energy Survey Supernova program, whose main focus was on using Type Ia supernovae for cosmology. By performing an architecture search of CNNs, we identify networks that efficiently select non-artifacts (e.g., supernovae, variable stars, AGN, etc.) from artifacts (image defects, mis-subtractions, etc.), achieving the efficiency of previous work performed with random Forests, without the need to expend any effort in feature identification. The CNNs also help us identify a subset of mislabeled images. Performing a relabeling of the images in this subset, the resulting classification with CNNs is significantly better than previous results, lowering the false positive rate by 27% at a fixed missed detection rate of 0.05.

Impact of targeted diabetic retinopathy training for graders in Vietnam and the implications for future diabetic retinopathy screening programmes: a diagnostic test accuracy study

ObjectivesTo compare the accuracy of trained level 1 diabetic retinopathy (DR) graders (nurses, endocrinologists and one general practitioner), level 2 graders (midlevel ophthalmologists) and level 3 graders (senior ophthalmologists) in...

Connected-SegNets: A Deep Learning Model for Breast Tumor Segmentation from X-ray Images.

Simple SummaryThe segmentation of breast tumors is an important step in identifying and classifying benign and malignant tumors in X-ray images. Mammography screening has proven to be an effective tool for breast cancer diagnosis. However, the inspection of breast mammograms for early-stage cancer can be a challenging task due to the complicated structure of dense breasts. Several deep learning models have been proposed to overcome this particular issue; however, the false positive and false negative rates are still high. Hence, this study introduced a deep learning model, called Connected-SegNets, that combines two SegNet architectures with skip connections to provide a robust model to reduce false positive and false negative rates for breast tumor segmentation from mammograms.Inspired by Connected-UNets, this study proposes a deep learning model, called Connected-SegNets, for breast tumor segmentation from X-ray images. In the proposed model, two SegNet architectures are connected with skip connections between their layers. Moreover, the cross-entropy loss function of the original SegNet has been replaced by the intersection over union (IoU) loss function in order to make the proposed model more robust against noise during the training process. As part of data preprocessing, a histogram equalization technique, called contrast limit adapt histogram equalization (CLAHE), is applied to all datasets to enhance the compressed regions and smooth the distribution of the pixels. Additionally, two image augmentation methods, namely rotation and flipping, are used to increase the amount of training data and to prevent overfitting. The proposed model has been evaluated on two publicly available datasets, specifically INbreast and the curated breast imaging subset of digital database for screening mammography (CBIS-DDSM). The proposed model has also been evaluated using a private dataset obtained from Cheng Hsin General Hospital in Taiwan. The experimental results show that the proposed Connected-SegNets model outperforms the state-of-the-art methods in terms of Dice score and IoU score. The proposed Connected-SegNets produces a maximum Dice score of 96.34% on the INbreast dataset, 92.86% on the CBIS-DDSM dataset, and 92.25% on the private dataset. Furthermore, the experimental results show that the proposed model achieves the highest IoU score of 91.21%, 87.34%, and 83.71% on INbreast, CBIS-DDSM, and the private dataset, respectively.

Quantification of spatial subclonal interactions enhancing the invasive phenotype of pediatric glioma.

SummaryDiffuse midline gliomas (DMGs) are highly aggressive, incurable childhood brain tumors. They present a clinical challenge due to many factors, including heterogeneity and diffuse infiltration, complicating disease management. Recent studies have described the existence of subclonal populations that may co-operate to drive pro-tumorigenic processes such as cellular invasion. However, a precise quantification of subclonal interactions is lacking, a problem that extends to other cancers. In this study, we combine spatial computational modeling of cellular interactions during invasion with co-evolution experiments of clonally disassembled patient-derived DMG cells. We design a Bayesian inference framework to quantify spatial subclonal interactions between molecular and phenotypically distinct lineages with different patterns of invasion. We show how this approach could discriminate genuine interactions, where one clone enhanced the invasive phenotype of another, from those apparently only due to the complex dynamics of spatially restricted growth. This study provides a framework for the quantification of subclonal interactions in DMG.

Transformer based tooth classification from cone-beam computed tomography for dental charting

Dental charting is a useful tool in physical examination, dental surgery, and forensic identification. However, manual dental charting faces some difficulties, such as inaccuracy and psychiatric burden in forensic identification. As a critical step of dental charting, tooth classification can be completed on dental cone-beam computed tomography (CBCT) automatically to solve the above difficulties. In this paper, we build a deep neuron network which accepts a 3D CBCT image patch that contains the region of interest (ROI) of a tooth as input and then outputs the type of the tooth. Although Transformer-based neural networks outperform CNN-based neural networks in many natural image processing tasks, they are difficult to apply to 3D medical images. Therefore, we combine the advantages of CNN and Transformer structure to improve the existing methods and propose the Grouped Bottleneck Transformer to overcome the drawbacks of the Transformer, namely the requirement of large training dataset and high computational complexity. We conducted an experiment on a clinical data set containing 450 training samples and 104 testing samples. Experiments show that our network can achieve a classification accuracy of 91.3% and an AUC score of 99.7%. To further evaluate the effectiveness of our method, we tested our network on the publicly available medical image classification dataset MedMNIST3D. The result shows that our network outperforms other networks on 5 out of 6 3-dimensional medical image subsets.

An integrated framework for breast mass classification and diagnosis using stacked ensemble of residual neural networks

A computer-aided diagnosis (CAD) system requires automated stages of tumor detection, segmentation, and classification that are integrated sequentially into one framework to assist the radiologists with a final diagnosis decision. In this paper, we introduce the final step of breast mass classification and diagnosis using a stacked ensemble of residual neural network (ResNet) models (i.e. ResNet50V2, ResNet101V2, and ResNet152V2). The work presents the task of classifying the detected and segmented breast masses into malignant or benign, and diagnosing the Breast Imaging Reporting and Data System (BI-RADS) assessment category with a score from 2 to 6 and the shape as oval, round, lobulated, or irregular. The proposed methodology was evaluated on two publicly available datasets, the Curated Breast Imaging Subset of Digital Database for Screening Mammography (CBIS-DDSM) and INbreast, and additionally on a private dataset. Comparative experiments were conducted on the individual models and an average ensemble of models with an XGBoost classifier. Qualitative and quantitative results show that the proposed model achieved better performance for (1) Pathology classification with an accuracy of 95.13%, 99.20%, and 95.88%; (2) BI-RADS category classification with an accuracy of 85.38%, 99%, and 96.08% respectively on CBIS-DDSM, INbreast, and the private dataset; and (3) shape classification with 90.02% on the CBIS-DDSM dataset. Our results demonstrate that our proposed integrated framework could benefit from all automated stages to outperform the latest deep learning methodologies.

An automatic breast computer‐aided diagnosis scheme based on a weighted fusion of relevant features and a deep CNN classifier

Mammography continues to play a central part in the early breast masses diagnosis and has raised several challenges in breast cancer detection. Nevertheless, it remains still difficult to detect abnormalities in a dense breast and some benign lesions may have similar appearance with masses. This study proposes a novel Computer-Aided Diagnosis (CADx) allowing benign and malignant mass classification. Accordingly, relevant textural-shape descriptors are proposed, which is the aggregation of a new Local Binary based feature, namely the Monogenic Gray Level and Local Difference (MGLLD), where both texture characteristics and breast tissue density information, and the Zernike moments are incorporated. A heuristic algorithm is then devised for optimizing the proposed features with respect to inter-class and intra-class distribution, by a convenient ponderation. Then, a set of classifiers are applied for opting to the best decision making solution. The Deep CNN yields the best accuracy, with an Area Under Curve (AUC) of 0.98 on Curated Breast Imaging Subset of DDSM (CBIS-DDSM). In addition, the authors are based on a subjective approval of the extracted Region Of Interest (ROI) by experts in radiology. The proposed scheme proves its effectiveness especially on some challenging breast cancer cases, corresponding to higher breast tissue density. In medical image processing, these results open new perspectives with respect to the use of the deep learning solutions, where the small sample-number is known to be a limitation (because pathologies cannot be intentionally provoked).

Abstract 1202: A repository of PDX histology images for exploring spatial heterogeneity and cancer dynamics

Abstract Patient-derived xenografts (PDXs) recapitulate intratumoral spatial heterogeneity and simulate a tumor microenvironment in which human immune and stromal cells in the PDX are replaced over passages by murine cells partially lacking immune function. Histological imaging enables exploring the spatial heterogeneity and dynamics of cancer, stromal, and immune cell interactions as correlates of tumor stage and therapeutic response over passages. We created a repository of curated, haematoxylin and eosin (H&E) images as a community resource for addressing these questions. Images were generated at five sites within the NCI’s PDX Development and Trial Centers Research Network (PDXNet) and the NCI Patient-Derived Models Repository. Over 900 images, including 739 from PDXs and 190 from paired patients, are hosted on the Seven Bridges Genomics Cancer Genomics Cloud. They represent 42 cancer subtypes, including breast cancer (n=134), colon adenocarcinoma (COAD; n=94), pancreatic cancer (n=87), lung adenocarcinoma (LUAD; n=80), melanoma (n=71), and squamous cell lung cancer (LUSC; n=65). Paired human/PDX images are available for each of these cancers. Human and/or PDX images generated following patient treatment are available for 37 of the subtypes. Most images are from early passages (P0: 158; P1: 292; P2: 152; P3: 69; >P3: 55). Annotations include sex, age, race, ethnicity, and, for most images, pathological assessment of tissue-level percent cancer, stromal, and necrotic cell content (n=639) and tumor stage (n=650). RNA and exome sequencing data are available for 99 and 228 images, respectively, matched at the patient or sample level. Quality control was performed using HistoQC. Cells were segmented and labeled as neoplastic, necrotic, immune, stromal, or other using Hover-Net and predictions of total neoplastic cell area correlated with whole-slide pathological assessment of cancer cell percentage (COAD: r=0.51; LUSC: r=0.59). HD-Staining, another classification approach, was applied to a subset of images and our clinical annotations will facilitate validation of this and related methods. Features of 512 x 512 pixel tiles were computed using the Inception V3 convolutional neural network pre-trained on ImageNet. Unsupervised clustering of these features demonstrate inter-patient heterogeneity within pathologist-annotated tumor regions. A classifier developed using pathologist-annotated cancer, stromal, and necrotic regions and trained on the features in LUSC images (n=10 images) achieved a cross-validation accuracy of 96% for cancer tiles across (n=5) LUAD images. Accuracy was lower for stromal classification (90%), likely reflecting current limitations of our small, but growing, labeled training set. Our repository of clinically-annotated PDX H&E images should aid the community in studying spatial heterogeneity and in training deep learning-based image analysis methods. Citation Format: Brian S. White, Xingyi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Akshat M. Savaliya, Lacey E. Dobrolecki, John D. Landua, Matthew H. Bailey, Maihi Fujita, Kurt W. Evans, Bingliang Fang, Junya Fujimoto, Maria Gabriela Raso, Shidan Wang, Guanghua Xiao, Yang Xie, Sherri R. Davies, Ryan C. Fields, R Jay Mashl, Jacqueline L. Mudd, Yeqing Chen, Min Xiao, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, PDXNet Consortium, Yvonne A. Evrard, Tiffany A. Wallace, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Moon S. Chen, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Michael T. Lewis, Ramaswamy Govindan, Li Ding, Shunqiang Li, Meenhard Herlyn, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Carol J. Bult, Brandi Davis-Dusenbery, Dennis A. Dean, Jeffrey H. Chuang. A repository of PDX histology images for exploring spatial heterogeneity and cancer dynamics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1202.

Exploring the Best Parameters of Deep Learning for Breast Cancer Classification System

Breast cancer is one of the deadliest cancers in the world. It is essential to detect the signs of cancer as early as possible, to make the survival rate higher. However, detecting the signs of breast cancer using the machine or deep learning algorithms from the diagnostic imaging results is not trivial. Slight changes in the illumination of the scanned area can significantly affect the automatic breast cancer classification process. Hence, the research aims to propose an automatic classifier for breast cancer from digital medical imaging (e.g., Positron Emission Tomography or PET, X-Ray of Mammogram, and Magnetic Resonance Imaging (MRI) images). The research proposes modified deep learning architecture with five different settings to model automatic breast cancer classifiers. In addition, five machine learning algorithms are also explored to model the classifiers. The dataset used in the research is the Curated Breast Imaging Subset of Digital Database for Screening Mammography (CBIS-DDSM). A total of 2,676 mammogram images are used in the research and are split into 80%:20% (2,141:535) for training and testing datasets. The results demonstrate that the model trained with eight layers of Convolutional Neural Networks (CNN) (SET-8) achieves the best accuracy score of 94.89% and 93.75% in the training and validation dataset, respectively.

An optimized deep learning architecture for breast cancer diagnosis based on improved marine predators algorithm

Breast cancer is the second leading cause of death in women; therefore, effective early detection of this cancer can reduce its mortality rate. Breast cancer detection and classification in the early phases of development may allow for optimal therapy. Convolutional neural networks (CNNs) have enhanced tumor detection and classification efficiency in medical imaging compared to traditional approaches. This paper proposes a novel classification model for breast cancer diagnosis based on a hybridized CNN and an improved optimization algorithm, along with transfer learning, to help radiologists detect abnormalities efficiently. The marine predators algorithm (MPA) is the optimization algorithm we used, and we improve it using the opposition-based learning strategy to cope with the implied weaknesses of the original MPA. The improved marine predators algorithm (IMPA) is used to find the best values for the hyperparameters of the CNN architecture. The proposed method uses a pretrained CNN model called ResNet50 (residual network). This model is hybridized with the IMPA algorithm, resulting in an architecture called IMPA-ResNet50. Our evaluation is performed on two mammographic datasets, the mammographic image analysis society (MIAS) and curated breast imaging subset of DDSM (CBIS-DDSM) datasets. The proposed model was compared with other state-of-the-art approaches. The obtained results showed that the proposed model outperforms the compared state-of-the-art approaches, which are beneficial to classification performance, achieving 98.32% accuracy, 98.56% sensitivity, and 98.68% specificity on the CBIS-DDSM dataset and 98.88% accuracy, 97.61% sensitivity, and 98.40% specificity on the MIAS dataset. To evaluate the performance of IMPA in finding the optimal values for the hyperparameters of ResNet50 architecture, it compared to four other optimization algorithms including gravitational search algorithm (GSA), Harris hawks optimization (HHO), whale optimization algorithm (WOA), and the original MPA algorithm. The counterparts algorithms are also hybrid with the ResNet50 architecture produce models named GSA-ResNet50, HHO-ResNet50, WOA-ResNet50, and MPA-ResNet50, respectively. The results indicated that the proposed IMPA-ResNet50 is achieved a better performance than other counterparts.

A Norm Minimization-Based Convex Vector Optimization Algorithm

We propose an algorithm to generate inner and outer polyhedral approximations to the upper image of a bounded convex vector optimization problem. It is an outer approximation algorithm and is based on solving norm-minimizing scalarizations. Unlike Pascoletti–Serafini scalarization used in the literature for similar purposes, it does not involve a direction parameter. Therefore, the algorithm is free of direction-biasedness. We also propose a modification of the algorithm by introducing a suitable compact subset of the upper image, which helps in proving for the first time the finiteness of an algorithm for convex vector optimization. The computational performance of the algorithms is illustrated using some of the benchmark test problems, which shows promising results in comparison to a similar algorithm that is based on Pascoletti–Serafini scalarization.

UAV-based bridge geometric shape measurement using automatic bridge component detection and distributed multi-view reconstruction

UAV cameras combined with image-based reconstruction are promising non-contact tools for bridge shape inspection while computational efficiency is low, particularly on large-scale image sets. This paper describes an efficient image-based reconstruction pipeline for bridge geometry measurements. A full bridge three-dimensional reconstruction task is decomposed into multiple distributed tasks of reconstructing bridge sub-models using sub-image sets. A deep learning-based object detection method combined with Euclidean clustering is proposed to automatically generate cropped sub-image sets. An image mask generation technique based on 3D-to-2D mesh projection is used to keep valid pixels for camera pose estimation. The proposed method was validated in a laboratory test for arch shape measurement and in a field test for suspension cable shape measurement. The results show significant improvement about computational efficiency without accuracy reduction, compared with conventional image reconstruction methods.

(Non)Marketing of Breastmilk Substitutes in South African Parenting Magazines: How Marketing Regulations May Be Working.

Although exclusive breastfeeding (EBF) for the first six months is optimal for child health, it remains low globally. Breastmilk substitutes (BMS) marketing undermines breastfeeding. In 2012, South Africa introduced Regulation 991, which prohibits marketing BMS products for infants below 6 months. Our study aimed to explore if and how BMS products were presented in South African parenting magazines post-R991. We applied a mixed-methods cross-sectional content analysis design, analyzing all 2018 issues of two popular parenting magazines. We descriptively analyzed quantitative codes, derived from an a priori framework, and conducted qualitative content analysis on a subset of texts and images. We found there was no overt marketing of BMS to parents with infants below 6 months. However, BMS advertisements were placed next to articles about young infants, and vague wording and images were ways by which BMS companies may indirectly benefit. Medical experts in both magazines promoted the introduction of solids before six months. To conclude, while BMS companies in South Africa were abiding by R991 by not overtly advertising BMS in parental print media, their influence persists. Continued monitoring of print media as well as other channels is advisable. This study may be of interest to countries considering stronger regulations of BMS advertising.

Image analysis-based quantification of the visual attributes of fish, with emphasis on color and visual texture

Abstract Images of Red Sea goatfish Parupeneus forsskali were taken in a light box to perform color and visual texture analyses. The average L* and b* values did not change significantly during storage of 7 days, but the a* values decreased (P < 0.05). The change of visual texture parameters energy and entropy (calculated based on histograms, and based on co-occurrence matrices [COM]), box counting-based fractal results, and texture change index (TCI) values are presented. The appearance of fish became “smoother” over time. The entropy values calculated by histograms decreased with storage (P < 0.05), and the maximum range was 0.395. That for COM-based entropies was 71.96. TCI also decreased with storage (P < 0.05) with a maximum range of 10.67. However, energy values increased during storage. The maximum range of the energy values calculated by histograms over time for any color channel was 0.0036. That for COM-based energies was 5.7. There was no observable change in fractal dimension. These image analysis-based parameters were compared with sensory analysis. A trained sensory panel evaluated the visual texture of a sub-set of images. The R2 values for equation fit between sensory score and texture features were, in increasing order: COM based energy (0.185), COM-based entropy (0.313), histogram-based energy (0.375), histogram-based entropy (0.386), TCI values (0.575). Since TCI correlated better with sensory values, it is recommended to be used in this type of visual texture evaluation.

Automatic Breast Tumor Screening of Mammographic Images with Optimal Convolutional Neural Network

Mammography is a first-line imaging examination approach used for early breast tumor screening. Computational techniques based on deep-learning methods, such as convolutional neural network (CNN), are routinely used as classifiers for rapid automatic breast tumor screening in mammography examination. Classifying multiple feature maps on two-dimensional (2D) digital images, a multilayer CNN has multiple convolutional-pooling layers and fully connected networks, which can increase the screening accuracy and reduce the error rate. However, this multilayer architecture presents some limitations, such as high computational complexity, large-scale training dataset requirements, and poor suitability for real-time clinical applications. Hence, this study designs an optimal multilayer architecture for a CNN-based classifier for automatic breast tumor screening, consisting of three convolutional layers, two pooling layers, a flattening layer, and a classification layer. In the first convolutional layer, the proposed classifier performs the fractional-order convolutional process to enhance the image and remove unwanted noise for obtaining the desired object’s edges; in the second and third convolutional-pooling layers, two kernel convolutional and pooling operations are used to ensure the continuous enhancement and sharpening of the feature patterns for further extracting of the desired features at different scales and different levels. Moreover, there is a reduction of the dimensions of the feature patterns. In the classification layer, a multilayer network with an adaptive moment estimation algorithm is used to refine a classifier’s network parameters for mammography classification by separating tumor-free feature patterns from tumor feature patterns. Images can be selected from a curated breast imaging subset of a digital database for screening mammography (CBIS-DDSM), and K-fold cross-validations are performed. The experimental results indicate promising performance for automatic breast tumor screening in terms of recall (%), precision (%), accuracy (%), F1 score, and Youden’s index.

Baseline characteristics of 547 new onset heart failure patients in the PREFERS heart failure study.

AimWe present the baseline characteristics of the PREFERS Stockholm epidemiological study on the natural history and course of new onset heart failure (HF) aiming to improve phenotyping focusing on HF with preserved left ventricular ejection fraction (HFpEF) pathophysiology.Methods and results New onset HF patients diagnosed in hospital or at outpatient HF clinics were included at five Stockholm hospitals 2015–2018 and characterized by N‐terminal pro brain natriuretic peptide (NT‐proBNP), biomarkers, echocardiography, and cardiac magnetic resonance imaging (subset). HFpEF [left ventricular ejection fraction (LVEF) ≥ 50%] was compared with HF with mildly reduced LVEF (HFmrEF; LVEF 41–49%) and with HF with reduced LVEF (HFrEF; LVEF ≤ 40%). We included 547 patients whereof HFpEF (n = 137; 25%), HFmrEF (n = 61; 11%), and HFrEF (n = 349; 64%). HFpEF patients were older (76; 70–81 years; median; interquartile range) than HFrEF (67; 58–74; P < 0.001), more often women (49% vs. 30%; P < 0.001), and had significantly higher comorbidity burden. They more often had atrial fibrillation, hypertension, and renal dysfunction. NT‐proBNP was lower in HFpEF (896; 462–1645 ng/L) than in HFrEF (1160; 563–2370; P = 0.005). In HFpEF, left ventricular (LV) diameters and volumes were smaller (P < 0.001) and septal and posterior wall thickness and relative wall thickness higher (P < 0.001). E/é ≥ 14 was present in 26% of HFpEF vs. 32% of HFrEF (P = 0.017) and left atrial volume index > 34 mL/m2 in 57% vs. 61% (P = 0.040). HFmrEF patients were intermediary between HFpEF and HFrEF for LV mass, LV volumes, and RV volumes but had the highest proportion of left ventricular hypertrophy and the lowest proportion of elevated E/é.ConclusionsPhenotype data in new onset HF patients recruited in a broad clinical setting showed that 25% had HFpEF, were older, more often women, and had greater comorbidity burden. PREFERS is well suited to further explore biomarker and imaging components of HFpEF pathophysiology and may contribute to the emerging knowledge of HF epidemiology.Clinical trial registration: Clinicaltrials.gov identifier: NCT03671122.

Detecting Alzheimer's Disease Using Natural Language Processing of Referential Communication Task Transcripts.

People with Alzheimer's disease (AD) often demonstrate difficulties in discourse production. Referential communication tasks (RCTs) are used to examine a speaker's capability to select and verbally code the characteristics of an object in interactive conversation. In this study, we used contextualized word representations from Natural language processing (NLP) to evaluate how well RCTs are able to distinguish between people with AD and cognitively healthy older adults. We adapted machine learning techniques to analyze manually transcribed speech transcripts in an RCT from 28 older adults, including 12 with AD and 16 cognitively healthy older adults. Two approaches were applied to classify these speech transcript samples: 1) using clinically relevant linguistic features, 2) using machine learned representations derived by a state-of-art pretrained NLP transfer learning model, Bidirectional Encoder Representation from Transformer (BERT) based classification model. The results demonstrated the superior performance of AD detection using a designed transfer learning NLP algorithm. Moreover, the analysis showed that transcripts of a single image yielded high accuracies in AD detection. The results indicated that RCT may be useful as a diagnostic tool for AD, and that the task can be simplified to a subset of images without significant sacrifice to diagnostic accuracy, which can make RCT an easier and more practical tool for AD diagnosis. The results also demonstrate the potential of RCT as a tool to better understand cognitive deficits from the perspective of discourse production in people with AD.

Multivariate curve resolution for analysis of Raman hyperspectral imaging data sets for enzyme immobilization

• Raman hyperspectral imaging of an enzyme immobilized onto two resins was accomplished. • Multivariate data analysis spectrally resolved chemical species involved in immobilization. • Chemical images spatially resolved chemical species involved in immobilization. • The Raman hyperspectral imaging data sets can be used for alternative applications. Biocatalytic processes are an essential component in achieving efficient and productive chemical syntheses in the scientific and industrial communities. Immobilization of the biocatalyst offers distinct advantages for the process, including increasing the stability and reusability of the biocatalyst as well as increasing control over the process. Herein, directly engineered pantothenate kinase (PanK) was immobilized to two commercially available microporous resins. Ralbovsky et al. (2021) utilized Raman hyperspectral imaging in combination with multivariate curve resolution alternating least squares (MCR-ALS) to spatially and spectrally resolve the chemical species involved in the enzyme immobilization process. Here, we provide eight Raman hyperspectral imaging data sets collected from the enzyme immobilized to the resin beads under different collection parameters, encompassing over 26,000 raw spectra. A brief discussion of the results, in the form of chemical maps and chemical images, indicates both resins, PanK, the glass substrate, and a Bis-Tris wash solution were resolved using MCR-ALS analysis of a subset of hyperspectral images, thus providing crucial chemical and spatial information about the system. The eight total Raman hyperspectral imaging data sets are shared to provide the scientific community with a thoroughly characterized set of spectral data which can be used for a variety of applications, including for further understanding and optimization of enzyme immobilization systems as well as for individual learning and development applications in the fields of chemical imaging and chemometrics.

SynthIA: A Synthetic Inversion Approximation for the Stokes Vector Fusing SDO and Hinode into a Virtual Observatory

Abstract Both NASA’s Solar Dynamics Observatory (SDO) and the JAXA/NASA Hinode mission include spectropolarimetric instruments designed to measure the photospheric magnetic field. SDO’s Helioseismic and Magnetic Imager (HMI) emphasizes full-disk, high-cadence, and good-spatial-resolution data acquisition while Hinode’s Solar Optical Telescope Spectro-Polarimeter (SOT-SP) focuses on high spatial resolution and spectral sampling at the cost of a limited field of view and slower temporal cadence. This work introduces a deep-learning system, named the Synthetic Inversion Approximation (SynthIA), that can enhance both missions by capturing the best of each instrument’s characteristics. We use SynthIA to produce a new magnetogram data product, the Synthetic Hinode Pipeline (SynodeP), that mimics magnetograms from the higher-spectral-resolution Hinode/SOT-SP pipeline, but is derived from full-disk, high-cadence, and lower-spectral-resolution SDO/HMI Stokes observations. Results on held-out data show that SynodeP has good agreement with the Hinode/SOT-SP pipeline inversions, including magnetic fill fraction, which is not provided by the current SDO/HMI pipeline. SynodeP further shows a reduction in the magnitude of the 24 hr oscillations present in the SDO/HMI data. To demonstrate SynthIA’s generality, we show the use of SDO/Atmospheric Imaging Assembly data and subsets of the HMI data as inputs, which enables trade-offs between fidelity to the Hinode/SOT-SP inversions, number of observations used, and temporal artifacts. We discuss possible generalizations of SynthIA and its implications for space-weather modeling. This work is part of the NASA Heliophysics DRIVE Science Center at the University of Michigan under grant NASA 80NSSC20K0600E, and will be open-sourced.