Illness In Women Research Articles

Breast implant illness in women with implant-based reconstruction after breast cancer

Abstract Background This study investigated the association between silicone breast implants and health symptoms (Breast Implant Illness (BII)) in women with implant-based breast reconstruction after breast cancer. While there is increasing evidence of an association with BII in cosmetic breast augmentation cases, for women with implant-based breast reconstruction this is unknown. Methods Retrospective cohort study of 254 women who underwent implant-based reconstruction after breast cancer and a control group of 487 women who underwent breast-conserving therapy or simple mastectomy. We linked Dutch Breast Implant Registry data (2015-2019) and general practice electronic health records data (2014-2022) to study the occurrence of thirteen BII-related health symptoms in general practice and the number of consultations for these symptoms one year before to three years after breast surgery. Results Over the three years following implantation, no significant differences in symptom occurrence were observed compared to both the year before implantation and the control group. Women with breast implants did not have more consultations compared to the control group during follow-up. However, there was an increased likelihood of multiple consultations in the first and second years post-implantation compared to before implantation (≥3 consultations first year OR = 2.10, p = 0.005; second year OR = 1.70, p = 0.048; ≥5 consultations first year OR = 2.57, p = 0.02). Conclusions This study found no evidence for BII in women with implant-based reconstruction after breast cancer. Despite certain limitations in examining BII in this specific patient group, these findings add valuable information to the decision-making process of breast cancer patients considering reconstructive options. Key messages • This is the first study on BII that focused solely on women with breast implants for reconstruction after breast cancer. • No evidence of BII was found in this patient group.

Breastfeeding Competency among Expectant Women

Breast milk serves as a vital source of nutrition for infants during the initial six months of life, offering a comprehensive array of essential nutrients.Breast milk serves as the optimal source of nutrition for infants, contributing to enhanced health outcomes throughout their lifespan and offering significant advantages to both families and society as a whole. The advocacy for breastfeeding can lead to a rise in family income through the preservation of infants' growth and development, as well as aiding in the recovery of women following childbirth. Consequently, this could result in increased labor force participation and demographic benefits for society.Moreover, it can contribute to the reduction of family and social medical costs by lowering the likelihood of short-term and long-term illnesses in women and infants. Results: The study results display that total effect of breastfeeding motivation on breastfeeding competency is .4419, p < 0.05. The direct effect of breastfeeding motivation on breastfeeding competency is .4608, p < 0.001. Conclusions: The student’s researcher concluded the following: The older the woman, the better the breastfeeding competency she exhibits. The better the socioeconomic status the family has, the better the breastfeeding competency the woman mirrors. The more perceived valuable breastfeeding to mothers and babies, the better the breastfeeding competency the woman reflects.

Molecular investigation of Her2 gene in Breast Cancer Women In Babylon City

Background: The most prevalent illness in women is breast cancer, “Human epidermal growth factor receptor 2 (HER2)” plays a significant role in the carcinogenesis of breast cancer. (HER2)” overexpression can arise from several causes and is frequently observed in 20–30% of instances of breast cancer. Aim of the study: The current study was aimed to investigate the correlation between the existence of HER2 gene expression in the peripheral blood samples with breast cancer females by using the primers of HER2 gene and PCR technique. Materials and Methods: In this study, seventy two (72) peripheral Blood samples were taken from the breast cancer ladies from Marjan Hospital's at Oncology Center in Babylon city's who had previously received a confirmatory diagnosis of breast cancer with ten (10) blood samples from clinically healthy women as a control group during the period from June 2022 to January 2023, DNA samples were isolated from the collected blood samples by DNA Extraction kit (FavorPrepTM Blood/Cultured Cells Genomic DNA Extraction Mini Kit), then, conventional PCR technique was performed with specific oligo primers to amplify the Her2 gene's target sequence in those DNA samples, then, agarose gel electrophoresis was applied for detecting the target sequence in the DNA products with the band size 150bp. Results: 58 / 72(80.5 %) of the DNA samples were positive and 14/ 72 (19. 5%) were negative for Her2 gene in the peripheral blood samples of the breast cancer women. Conclusions: in conclusion the current study's results demonstrated that 58/ 72 (80.5%) of the peripheral blood samples from breast cancer women were positive and the remaining 14/ 72(19.5%) of the peripheral blood samples were negative for Her-2 gene, “HER2 gene” can be considered as a useful biomarker and an obvious indicator for breast cancer which could be employed for early and confirmatory diagnosis of breast cancer in women.

An essay on the Charcot and Richer hysteria: from charcoal drawings to cell phones.

Hysteria, previously also known as the disease of the womb, has moved from being a woman's illness through the medieval times' stigma of demonic possession, to the modern concept of a functional neurological disorder. Interestingly to the present assay, Charcot (1825-1893) and Richer (1849-1933) described, in their 1887 work Les Démoniaques dans l'art, by means of iconography, semiological aspects of the so-called Grande Attaque Hystérique, which resembles features of psychogenic nonepileptic seizures emulating grand mal epileptic seizures. The aim of the present assay is to describe how those charcoal iconographic representations evolved through history and are nowadays portrayed in videos recorded at epilepsy monitoring units and patients' cell phones.

Impacts of women's work and childcare on child illness among Bangladeshi Shodagor communities

For decades, women's employment has been seen as crucial for achieving greater autonomy and empowerment for women, and for promoting better health and nutrition outcomes for children, particularly in low- and middle-income countries (LMIC). However, numerous empirical studies of the relationship between women's work and child outcomes have shown mixed results. Our study tests the assumptions of a model that suggests loss of maternal care during working hours may produce negative health outcomes for children. We use longitudinal data collected from traditionally semi-nomadic, boat-dwelling Shodagor families in Matlab, Bangladesh to determine the importance of maternal care as a mechanism influencing the relationship between women's work and child illness. We use Bayesian linear mixed models to assess the influence of occupation and amount of care on average days of child illness per month, and also to examine the role that allomothers play in buffering against potential negative impacts of lost maternal care on child illness. Results show that children who receive more care from mothers experience fewer days of illness, and that availability of high-quality alloparents mediates the relationship between maternal work and child health. These results indicate that both the care and resources provided by mothers influence children's biological outcomes. This has important implications for policy and aid interventions in LMIC, which have been developed to capitalize on an assumed positive relationship between maternal work and child health and nutrition.

The Relationship between Lifestyle Behaviors and Mental Illness in Women in College.

Women, particularly those in college, have the highest prevalence of any mental illness (MI), which negatively impacts social connection, academic performance, and health. Research into alternative treatment methods suggests that lifestyle behaviors are safer and more effective than medication at reducing MI symptoms. This study explores the relationship between lifestyle behaviors and MI in college women through an online survey. The survey included a food frequency questionnaire (Diet History Questionnaire II) and questions about lifestyle behaviors, symptoms of MI, and sociodemographic information. Diet quality was calculated using the Healthy Eating Index (HEI), and MI was assessed using the Depression, Anxiety, and Stress Scale-21. Independent sample t-tests, ANOVA, and chi-square analyses were conducted. A total of 222 women completed the survey. Overall, diet quality was poor, with a mean HEI of 62.6 ± 10.4. No significant differences or associations were found between MI groups for total HEI score, sleep, or tobacco use. However, alcohol use was significantly associated with MI (p = 0.049). Individuals with fewer concurrent unhealthy lifestyle behaviors had less severe symptoms of depression (p = 0.009) and anxiety (p < 0.001) compared to those with more unhealthy lifestyle behaviors. In this study, alcohol use was the only independent lifestyle behavior associated with symptoms of MI. We also found an association between the number of concurrent unhealthy lifestyle behaviors and depression and anxiety symptoms. Future research should explore the benefits of a healthy lifestyle on MI in a more diverse sample of women.

Breast Cancer Prediction Using Oversampling Technique, Particle Swarm Optimization, and Fuzzy Logic

Background: Breast cancer is one of the most devastating and prominent reasons for women's life loss on the planet today. Therefore, the development of tools for the early detection of breast cancer based on the use of a large amount of available clinical data in combination with machine learning/artificial intelligence models can be a cost-effective and game-changer solution for saving women's lives. Researchers have been working hard to put such a tool into practice in recent years. Introduction: Breast cancer is a serious health issue, and detecting it early is crucial to improving patient outcomes. Breast cancer is the second most prevalent chronic illness in women behind lung cancer and can also affect males, though it does so significantly on a smaller scale Objective: For early detection of breast cancer, a wide range of methods, including oversampling, feature selection, fuzzy logic, and machine learning algorithms, have been explored. This research article aims to predict the type and risk factors of breast cancer. Methods: In this study, the support vector machine-synthetic minority oversampling technique (SVM-SMOTE) was used to balance the Wisconsin Breast Cancer Original (WBCO) dataset from the UCI repository. To enhance the models’ performance and decrease the number of features, features were extracted using particle swarm optimization (PSO). Furthermore, thirteen types of models are proposed: Decision Tree (DT), Logistic Regression (LR), Random Forest (RF), Naïve Bayes (NB), K-Nearest Neighbors (KNN), Support Vector Machine (SVM), Gradient Boosting (GB), Extreme Gradient Boosting (XGB), Adaptive Boosting (AB), Categorical Boosting (CB), Light Gradient Boosting Machine (LGBM), Multi-Layer Perceptron (MLP), and Extra Trees (ET). The PSO-suggested features are utilized as input fuzzy variables, and fuzzy logic is trained. Results: As a result of these proposed techniques, the highest accuracy was obtained at 92.64%, 98.31%, and 97.19% using SVM-SMOTE, SVM-SMOTE+PSO, and PSO+fuzzy logic, respec-tively. Conclusion: In our investigation, we used fewer attributes (three), such as clump thickness, mar-ginal adhesion, and Bland chromatin, in the fuzzy logic systems and obtained satisfactory results.

Follicular Fluid and Blood Monitorization of Infertility Biomarkers in Women with Endometriosis.

Infertility is recognized globally as a social disease and a growing medical condition, posing a significant challenge to modern reproductive health. Endometriosis, the third-most frequent gynecologic disorder, is one of the most common and intricate conditions that can lead to female infertility. Despite extensive research, the etiology, malignant transformation, and biological therapy of endometriosis remain unknown. Blood and follicular fluid are two matrices that have been carefully studied and can provide insights into women's health. These matrices are clinically significant because they contain metabolites closely associated with women's illness stage and reproductive outcomes. Nowadays, the application of metabolomic analysis in biological matrices may be able to predict the outcome of assisted reproductive technologies with greater precision. From a molecular viewpoint on reproductive health, we evaluate and compare the utilization of human follicular fluid and blood as matrices in analysis for diagnostic and assisted reproductive technology (ART) predictors of success for endometriosis patients. In the follicular fluid (FF), plasma, and serum of endometriosis-affected women, researchers identified dysregulations of oxidative stress, upregulation of several immune factors, and aberrations in energy metabolic pathways. The altered signatures negatively correlate with the overall oocyte and embryo quality and fertilization rate.

Efficacy and Safety of Human Umbilical Cord Mesenchymal Stem Cells in Improving Fertility in Polycystic Ovary Syndrome Mice

Background: Polycystic ovary syndrome (PCOS) is the most prevalent reproductive endocrine illness in women of reproductive age and is one of the most important causes of female infertility. The pathogenesis of PCOS is complex. Although mesenchymal stem cell therapy is anticipated to be a successful treatment for PCOS, its long-term safety, including tumorigenesis in patients, remains unknown. Objective: This study aimed to confirm the efficacy and safety of human umbilical cord mesenchymal stem cells in improving fertility in PCOS mice. Methods: In this study, dehydroepiandrosterone (DHEA) was used to construct a C56BL/6 mouse PCOS model, human umbilical cord mesenchymal stem cells (hUC-MSCs) were used as a treatment, and the reproductive phenotype was observed in parallel breeding experiments to confirm the efficacy of the treatment. A 4-month follow-up period, final blood tests, and organ histology were carried out to confirm the long-term safety of the treatment. Results: After hUC-MSCs treatment, the sex hormone disorder of mice was corrected, the morphology and function of the ovary were improved, the number of offspring was significantly increased compared to the control group, and no adverse reactions related to stem cell transplantation such as tumor formation were found within 4 months. Conclusion: The treatment of hUC-MSCs is safe and effective in treating PCOS over the long term.

Lifestyle changes and Nutrition in Polycystic Ovarian Disorder: A Holistic Review

Polycystic Ovarian Disorder (PCOD) is a prevalent endocrine illness in women of reproductive age which is a reproductive and metabolic disorder. It shows hormonal abnormalities in which there is an excessive production of androgens and that is one of the main causes of infertility, diabetes, irregular menstrual periods, hirsutism, hair loss, obesity and acne. One of the main features of PCOD is the presence of cysts on the ovaries, which can affect their ability to release eggs regularly and Anti-Müllerian hormone (AMH) plays an inhibitory role in follicular development and recruitment, contributing to follicular arrest. AMH inhibitory action on FSH-induced aromatase production likely contributes to hyperandrogenism in PCOD. Some factors which can cause of PCOD such as lack of exercise, skipping breakfast, fast food, unbalanced sleep, obesity, genetic, environmental factors and stress level. Lifestyle and nutrition can affect PCOD development and maintenance in PCOD can be done by lifestyle changes such as diet regulation (in taking of vitamins, antioxidant and Creatine) and exercise, as well as medications to regulate hormones, improve fertility and sleep which play a vital role in PCOD management.

Sex Differences in Stress-Induced Cortisol Response Among Infants of Mothers Exposed to Childhood Adversity

BackgroundAdverse childhood experiences (ACEs) increase risk for mental illness in women and their children, and dysregulation of the hypothalamic-pituitary-adrenal axis may play a role. The impact of ACEs on the hypothalamic-pituitary-adrenal axis may be strongest when ACEs occur prepubertally and in people who are exposed to abuse ACEs. MethodsTo test this, we measured salivary cortisol in 96 mother-infant dyads while mothers were separated from their infants, who were experiencing a laboratory stressor. Mothers completed the Adverse Childhood Experiences Questionnaire; ACEs that occurred prepubertally (pACEs) were measured, and mother-infant dyads were grouped based on maternal pACE history as follows: no pACEs, ≥1 pACEs with abuse, or ≥1 pACEs but no abuse. ResultsMothers with ≥1 pACEs exhibited decreases in cortisol (relative to preinfant stressor), which differed significantly from the cortisol increase experienced by mothers with no pACEs, regardless of abuse presence (p = .001) or absence (p = .002). These pACE groups did not differ from one another (p = .929). Significant sex differences in infant cortisol were observed in infants of mothers with ≥1 pACEs (regardless of abuse) but not in infants of mothers with no pACEs. When mothers had experienced ≥1 pACEs, males showed decreases in cortisol in response to a stressor whereas females demonstrated increases, and males and females differed significantly when their mothers had ≥1 pACEs with (p = .025) and without (p = .032) abuse. ConclusionsRegardless of maternal exposure to childhood abuse, in response to a stressor, pACEs were associated with lower cortisol response in mothers and sex differences in 6-month-old infants, with males showing a lower cortisol response than females.

A Comparative Study of Fresh versus Frozen Embryo Transfer and their Outcomes in Patients with Polycystic Ovarian Syndrome

Background: In in vitro fertilization (IVF)/assisted reproductive technology, fresh embryo transfer is generally preferred over frozen embryo transfer (FET). Still, some research shows that FET could increase the childbirth rate which reduces the amount of ovarian hyperstimulation syndrome (OHSS) and pregnancy problems in females with polycystic ovarian syndrome (PCOS). There is a high risk of aberrant pregnancies, incorrect placentation, and other issues when a fresh embryo is transferred. They are more likely to get OHSS. Fresh embryo transfer reduces the chances to get pregnant as the stimulatory effect will be there for long time, and the endometrium is less receptive for the embryos and vice versa in the case of FET. For IVF, the transfer of fresh embryos is typically preferred over the transfer of frozen embryos. However, some research suggests that the transfer of frozen embryos may increase the live birth rate and decrease the rates of OHSS and pregnancy complications in women with polycystic ovary syndrome. One of the most prevalent endocrine illnesses in women of reproductive age is PCOS. Chronic anovulation, hyperandrogenemia, and clinical signs of hyperandrogenism are hallmarks of polycystic ovary syndrome in the absence of additional diseases such as congenital adrenal hyperplasia, androgen-producing tumors, or Cushing syndrome. Despite the fact that some patients are discovered to be clomiphene citrate (CC) resistant, CC is still the first line of treatment for anovulatory infertility caused by PCOS. Numerous treatments, such as the usage of metformin, ovarian drilling, and gonadotropin therapy, may be taken into consideration in these people. Materials and Methods: Fifty women in all ranging in age from 25 to 45 participated in the study. Half of the study participants are from Wardha, and the other half are from rural areas close to Wardha. Participants were chosen from patients who sought medical attention for issues relating to infertility. We have taken consent from all the patients with the mutual understanding that their medical is being used for a comparative study. All the patients in our study are subjected to IVF following embryo transfer. We have taken n = 50 in which all the patients are PCOS patients with AMH noticeably higher than others. Out of them, we have taken 25 patients who are allocated for fresh Day 5 transfer and 25 of them are allocated for Day 5 FET. We have collected data for a total of 50 patients and compared the β-human chorionic gonadotropin values whether it is positive or negative in each case. We have done a comparative study by comparing the results of patients undergoing fresh versus FET with their ages ranging from 25 to 45 years. Results: The data of fresh Day 5 embryo and frozen Day 5 transfer and their outcome were noted. We concluded that FET has good results compared to fresh embryo transfer.

Evaluation of the Efficacy and Safety of Dienogest in the Treatment of Primary Dysmenorrhea: A Study in a District-Level Hospital in Bangladesh

Background: Dysmenorrhea is a common symptom secondary to various gynecological disorders, but it is also represented in most women as a primary form of disease. Pain associated with dysmenorrhea is caused by hypersecretion of prostaglandins and an increased uterine contractility. The primary dysmenorrhea is quite frequent in young women and remains with a good prognosis, even though it is associated with low quality of life. Objectives: The aim of this study is to evaluate of the efficacy and safety of dienogest in the treatment of primary dysmenorrhea: a study in a district-level hospital in Bangladesh. Methods: The cross-sectional observational study was conducted in the Department of Gynae and Obs, Naogaon Sadar Hospital from July 2022 to June 2023. A total of 100 subjects who received DNG (1 mg/day, orally) were included in the study. Data were collected by face-to-face interview and analyzed by appropriate computer based programmed software Statistical Package for the Social Sciences (SPSS), version 24. Results: In this study, most of the patients 43% lies between 21 years to 25 years and body weight of 24% patients were between 51 to 55 kg. In this study, most of the patients 41% body mass index were 18.5 – 24.9 kg/m2. Most of the patients’ clinical symptoms were cramping pain in the lower abdomen (89%), low back pain (86%), pain spreading down to the leg (73%), fatigue (64%). About (56%) adverse effects were body weight gain and irregular uterine bleeding occurred in 35 of 100 cases (35%). Conclusion: Primary dysmenorrhea is one of the most common illnesses in women of childbearing age. When severe, it may interfere with the activities of daily living and may lead to school and work absenteeism. Primary dysmenorrhea is also one of the most underdiagnosed diseases, so clinicians should suspect the diagnosis in a timely manner and provide appropriate treatment.

The Problem of Diagnostic Criteria of Breast Implant Illness in Women After Breast Reconstruction: Review and Discussion of a Case.

There has been a rising trend in the use of silicone breast implants for breast reconstructions after breast cancer treatment, as well as in the aesthetic breast procedures. A cluster of non-specific symptoms related to the presence of silicone implant has been called breast implant illness (BII). However, there are no strict criteria of BII which would specifically define this term. The increasing interest in BII among patients and physicians urges verifying own cases of "on-demand" explantations. In this paper, we discussed a case of a patient with initial BII diagnosis, after breast reconstruction, and reviewed the literature on the BII symptoms and aetiology. A decision for aesthetic revision, not explantation, was made as the diagnosis of BII was questioned, and somatisation due to dissatisfaction with the aesthetic result of breast reconstruction was diagnosed. Improving aesthetics by implant exchange and contralateral mastopexy caused a full recovery from patient's symptoms. Based on our case, we point on the fact that BII diagnosis in patients after breast reconstruction is challenging. We suggest that while considering such a diagnosis and further proceedings, e.g. explantation, especially in patients after breast reconstruction, some exclusion criteria should be considered. Dissatisfaction with the result of the surgery can also lead to somatisation and the presence of real clinical symptoms, which should not be confused with the possible autoimmune reaction to silicone particles. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Prevalence and Dietary Management of Polycystic Ovary Syndrome among Libyan Women Attending in Infertility Center Tripoli, Libya

Polycystic ovarian syndrome (PCOS) is the most common heterogenic endocrine illness in women of reproductive age, caused mostly by an excess of androgen and ovarian dysfunction. The present study was carried out to estimate the prevalence of PCOS among Libyan women who attended infertility center Tripoli, Libya, from 2020-2022, evaluate hormonal profile, Body Mass Index, weight and west circumferential before and after treatment and diet management. A longitudinal cross-sectional study conducted in the Tripoli Fertility Center in Tripoli, Libya, the study population targeting output Libyan female patients who presented to the gynecology and obstetrics (OPD) department and therapeutic nutrition department. Data Retrospectively collected from 2020 until 2022 and diagnosed using Rotterdam’s criteria. A total of 603 patients visited the gynecology and obstetrics department and the therapeutic nutrition department between January 2020 and December 2022. Out of which 174 women in the PCOS group and 429 in the non-PCOS group. The prevalence of PCOS was 29.56% in 2020, 37.5% in 2021, and 20.27% in 2022. The mean age of PCOS was 34.90 ± 5.5 SD, and all of the PCOS group were married. Worth to mention that all of PCOS cases was insulin resistance type. In terms of weight in the PCOS group, 19.54% were obese BMI &gt;29, 68.96% were morbid obese with BMI &gt;35, and approximately 68.39% of waist circumference measurements were more than 88cm. Hirsutism and oligomenorrhea were the major clinical features, morbid obese seems to be more prevalent in Libyan PCOS patients, low carbohydrate diet and physical activities may play an important role in PCOS management.

Attitude to the child's illness and parental burnout of women raising children with autism spectrum disorders

The subject of the study is the parental burnout of women raising children with autism spectrum disorders. Special attention is paid to the type of attitude to the mother's child's illness and her emotional burnout. The aim of the study is to identify the relationship of parental burnout with the type of attitude to the child and his illness in women raising children with autism spectrum disorders. Theoretical analysis of scientific research on the problem of emotional burnout of parents raising children with autism spectrum disorder allows us to conclude that each family faces huge problems of a different nature, which leads to chronic stress, flowing into emotional burnout. Different types of attitudes to the disease can aggravate this condition. The main conclusions of the study are presented in the provisions. Parental burnout of women raising children with autism spectrum disorders is determined by the peculiarities of emotional relationships with the child. Data were obtained on different relationships between the symptoms of parental burnout and the type of relationship with a child of different ages. Emotional exhaustion, depersonalization, reduction of parental achievements are interrelated with the peculiarities of contact with the child, the inability to understand the child, feelings arising in interaction with the child, the inability to provide emotional support to the child. The type of attitude to the child's illness is determined by the peculiarities of the emotional relationship between mother and child. Thus, the predictors of the types of attitude to the child's illness are the feelings that arise in the mother's relationship with the child, a negative attitude towards herself as a mother, unconditional child, restrictions on activity and physical contact.

Pregnancy-Associated Plasma Protein-A: Implications for Heart Failure and Cardiovascular Risks in Women – A Review

Pregnancy-associated plasma protein-A (PAPP-A), is gaining interest as a possible biomarker and contributory factor to female cardiovascular health issues. This review article highlights the increasing amount of research connecting PAPP-A to heart failure and other cardiovascular concerns in females. PAPP-A levels have been found to be higher in women with heart failure and also been linked to the development and advancement of cardiovascular risks (atherosclerosis and coronary artery disease) in women. Improvements in risk assessment, early identification, and customized therapies for cardiovascular illnesses in women may be made possible by developments in this sector.

Community Based Study of Rural Tribal Women’s Prepregnancy Health

Background: In addition to health during pregnancy, labour, post-birth, an optimal state of physical and mental health at the onset of pregnancy is essential for health of women and their babies during pregnancy, birth, and post birth over decades. The concept of preconception health has been old; however it has received little attention until recently. There has now been momentum because of persisting sufferings of women during pregnancy, birth and beyond in spite of best of care during pregnancy. Objective: Present community based study was conducted to know about prepregnancy health, body mass index (BMI), hemoglobin (Hb), any major illnesses in women of a remote rural region. Material and methods: After the institution’s ethics committee’s approval, community based study was conducted in 100 villages with health facilities in forestry and hilly regions. Total 2400 women of reproductive age, likely to have pregnancy were included randomly, minimum 20 from each village to get information as per objective. Results: Among 2400 women, 22.8% had low BMI, 56.6% normal, 26.6% high BMI, 10% women had &lt;5gm/dl Hb, 20.5% ≥ 5 but &lt;7 gm/dl Hb, 33.7% ≥ 7 but &lt;9 gm/dl Hb, 12% Hb ≥ 9 but &lt;11gm/dl Hb, 23.6% women had Hb ≥ 11gm/dl Hb. Total 12.1% women had hypertension, 8.4% had diabetes, 79.5% had other disorders, mostly anemia. Conclusion: There were 22.8% underweight tribal women with chances of other nutritional deficiencies, 30.54% had severe and 33.75% had moderate anemia, 10% had alarming very severe anemia, real cause of concern. Government health providers need to identify various disorders of prepregnancy which can become dangerous during pregnancy, birth, post birth for both mother and baby. It is also important to address them in later life through various preventive and therapeutic interventions.

Neo-adjuvant PIPAC and Systemic Chemotherapy in Management of Synchronous Peritoneal Metastasis From Gastric Cancer

Introduction: Polycystic Ovarian Disorder (PCOD) is a prevalent endocrine illness in women of reproductive age. It has hormonal abnormalities, irregular menstrual cycles and tiny ovarian cysts. Lifestyle and food affect PCOD development and maintenance, coupled with Peritoneal metastasis from gastric cancer remains a major problem. The aim of our study is a retrospective analysis in two different groups with used PIPAC as neo-adjuvant management of synchronous peritoneal metastasis. Group A: 42 patients received as neo-adjuvant treatment 2 cycles of PIPAC (Doxorubicin 3 mgr/m2, cisplatin 10 mgr/m2) and 6 cycles of neo-adjuvant systemic chemotherapy with FLOT and we performed CRS+HIPEC (with cisplatin 80 mgr/m2, mitomycin 35 mgr/m2) for 90 min and 6 cycles of adjuvant systemic chemotherapy with FLOT. Group B: 26 patients received 4 cycles of neo-adjuvant systemic chemotherapy with FLOT, we performed CRS+HIPEC as Group A and 4 cycles of systemic chemotherapy with FLOT. For patients of Group A, the Median survival time is 46months.Group B patients had a median OS of 36 months. For patients of Group A, the Median Disease Time (DFS) was 37 months. Group B patients had a median DFS of 30 months. For each degree increase in the PCI pre score and for the same treatment group, the PCI posr score increases by 0.573 degrees. Group 2, for the same PCIpre score, have a 163% higher PCI posr score. On patients with singet ring cell adenocarcinoma there is a statistical significance difference in OS for PIPAC group. Patients of group A had a median OS of 26 months. For patients of group B, the median OS was 14 months. Morbidity and mortality in both groups are 53,4% and 4,7% for Group A and 44,5% and 5,5% for Group B respectively. The neo-adjuvant PIPAC with systemic chemotherapy might be a promising approach for patients with peritoneal metastasis from gastric cancer. PIPAC is a safe and well tolerated procedure.

Optimizing Polycystic Ovarian Disorder (PCOD) Treatment with Personalized Lifestyle and Nutrition Strategies

Introduction: Polycystic Ovarian Disorder (PCOD) is a prevalent endocrine illness in women of reproductive age. It has hormonal abnormalities, irregular menstrual cycles and tiny ovarian cysts. Lifestyle and food affect PCOD development and maintenance, coupled with medical therapies. Lifestyle, diet and PCOD are interconnected in this thorough assessment. Methodology: The evaluation comprises PCOD, lifestyle, diet, exercise, stress management and nutrition research published between January 1, 2000 and May 1, 2023. Result: PCOS management requires lifestyle changes including frequent exercise, a healthy weight, nutritious diet and no cigarettes. While lifestyle modifications cannot substitute medical care, they improve well-being. Low-GI, ketogenic and omega-3 fatty acid diets may reduce insulin resistance and PCOS symptoms. Eating no Saturated Fats (SFAs) is also important. Exercise improves insulin sensitivity, but high-intensity sessions improve cardiorespiratory fitness, insulin resistance and body composition more. We propose intense aerobic and strength training. PCOS might worsen insulin resistance due to sleep disruptions. Getting enough sleep is important for metabolism. PCOS sufferers may have reduced melatonin, which regulates the body’s 24-hour schedule, underlining the significance of sleep. Vitamin D, inositol, folate, B-group vitamins, vitamin K and vitamin E may improve insulin sensitivity and hormonal balance. Vitamins including bioflavonoids, carnitine and alpha-lipoic acid and minerals like chromium picolinate, calcium, magnesium, selenium and zinc may also help PCOS sufferers. More study is required to prove their effectiveness. Conclusion: PCOD is complicated and needs comprehensive treatment. Lifestyle, food and medical therapies should be combined for best outcomes. Healthcare practitioners and PCOD patients must collaborate to create tailored lifestyle, diet and supplement recommendations. Improve these remedies for the PCOD community with further study.