You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder I1 Apr 2018MP10-11 THE IMPACT OF CHANGE IN PROPHYLACTIC ANTIBIOTICS ON INFECTIOUS COMPLICATIONS AFTER RADICAL CYSTECTOMY WITH ORTHOTOPIC NEOBLADDER Wan Song, Hyun Suk Yoon, Kwang Hyun Kim, Chung-Jong Kim, Hana Yoon, Woo Sik Chung, Bong Suk Sim, In-Rae Cho, Hee Jung Choi, and Dong Hyeon Lee Wan SongWan Song More articles by this author , Hyun Suk YoonHyun Suk Yoon More articles by this author , Kwang Hyun KimKwang Hyun Kim More articles by this author , Chung-Jong KimChung-Jong Kim More articles by this author , Hana YoonHana Yoon More articles by this author , Woo Sik ChungWoo Sik Chung More articles by this author , Bong Suk SimBong Suk Sim More articles by this author , In-Rae ChoIn-Rae Cho More articles by this author , Hee Jung ChoiHee Jung Choi More articles by this author , and Dong Hyeon LeeDong Hyeon Lee More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.357AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Radical cystectomy (RC) is the standard treatment for muscle infiltrating or recurrent, high-risk non-muscle invasive bladder cancer and ileal orthotopic neobladder (IONB) is the currently preferred urinary diversion. However, infectious complication is one of major concerns after surgery. Therefore, we investigated the impact of short-term prophylactic antibiotic on infectious complications after RC with IONB METHODS We reviewed 287 patients who underwent RC with IONB for bladder cancer between 2012 and 2016. Patients were divided into two groups according to the pattern of prophylactic antibiotic (185 patients in pre-intervention, 25days use of 3 staged-multiple antibiotics vs. 102 patients in post-intervention, 24 hours use of 2ndcephalosporin). Onset of infectious complications including bacteriuria, febrile urinary tract infection (FU) and bacteremia, and microorganisms in infectious complications were compared between two groups. RESULTS Of the total 287 patients, bacteriuria, FU and bacteremia were identified in 177 (61.7%), 58 (20.2%) and 18 (6.3%) patients. When compared between two groups, bacteriuria was more frequently identified in post-intervention group (49.2% vs 84.3%, p<0.001). However, FU within 60-day of surgery was 28.6% in pre-intervention group and 28.4% in post-intervention group (p=0.969). Overall FU was not significantly different. Also, bacteremia was not significantly different (5.4% vs 7.8%, p=0.415). The most frequent microorganism in bacteriuria was Enterococcus faecium in pre-intervention, while Enterococcus faecalis in post-intervention group. Enterococcus species resistant to ampicillin or vancomycin were more frequent in pre-intervention group. CONCLUSIONS Short-term use of prophylactic antibiotics is effective in preventing infectious complications after RC with IOBN as well as decreasing colonization with multi-resistant organisms. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e120 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Wan Song More articles by this author Hyun Suk Yoon More articles by this author Kwang Hyun Kim More articles by this author Chung-Jong Kim More articles by this author Hana Yoon More articles by this author Woo Sik Chung More articles by this author Bong Suk Sim More articles by this author In-Rae Cho More articles by this author Hee Jung Choi More articles by this author Dong Hyeon Lee More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...