This research aimed to know the concept of coexistence in Islam, especially in relation to the civil society built by the Prophet Muhammad, may God bless him and grant him peace, in Medina, which represents the model structure of civilizational coexistence with others. Moreover, it raises a set of questions about the concept of coexistence, the concept of the other, and the reality of coexistence in the Medina society (the society built by the Prophet, peace and blessings be upon him), in addition to the controls and forms of this coexistence. Therefore, the importance of this research is evident in clarifying modern concepts related to the relationship with others in civil society. This is done through the Prophetic applications in the Islamic community in Medina. The research clarifies the nature of relationships within the Prophet’s community and the forms of cultural relationship with others. Furthermore, it highlights the extent of our need for guidance and to follow the approach adopted by the Prophet, may God bless him and grant him peace, in civilizational coexistence with others. The research is based on the inductive analytical approach in examining the hadiths and Prophetic events that focus on clarifying the concept of coexistence with others, the controls and determinants of coexistence with others in the Prophetic civil society, and explaining the impact of coexistence on civil society. The results showed that the civil society founded by the Prophet, PBUH, in Medina was characterized by great civilizational principles that demonstrate justice, mercy, and good human behaviours. These principles reflect the need to highlight the Prophetic values of civilized coexistence that prevailed in civil society and how to deal with others in the current era, especially in light of the emergence and spread of ideologies of hatred and racism that have generated many negative convictions about the Islamic approach to coexistence with others.