Identification Of Antimicrobial Compounds Research Articles

Isolation and Identification of Antimicrobial Compounds in Brazilian Propolis

Three distinct antimicrobial compounds were isolated from Brazilian propolis. These compounds were identified as 3,5-diprenyl-4-hydroxycinnamic acid (1), 3-prenyl-4-dihydrocinnamoloxycinnamic acid (2), and 2,2-dimethyl-6-carboxyethenyl-2H-1-benzopyran (3).The respective antimicrobial activity, expressed as MIC in μg/ml, 1–3 against Bacillus cereus was 15.6, 31.3, and 125; that against Enterobacter aerogenes was 31.3, 62.5, and 125; and that against Arthroderma benhamiae was 15.6, > 250, and 62.5. Compound 1 is likely to be one of the major antimicrobial compounds in Brazilian propolis.

Identification of antimicrobial compounds in heated neutral glucose and fructose solutions

The antimicrobial activity occurring in heated neutral glucose and fructose solutions was shown to result from phenolic di- or tri-hydroxy compounds. Twelve such compounds were identified in glucose solutions heated for 120 minutes at 120 °C. The antimicrobial spectra of these compounds were also investigated.