Abstract
Three distinct antimicrobial compounds were isolated from Brazilian propolis. These compounds were identified as 3,5-diprenyl-4-hydroxycinnamic acid (1), 3-prenyl-4-dihydrocinnamoloxycinnamic acid (2), and 2,2-dimethyl-6-carboxyethenyl-2H-1-benzopyran (3).The respective antimicrobial activity, expressed as MIC in μg/ml, 1–3 against Bacillus cereus was 15.6, 31.3, and 125; that against Enterobacter aerogenes was 31.3, 62.5, and 125; and that against Arthroderma benhamiae was 15.6, > 250, and 62.5. Compound 1 is likely to be one of the major antimicrobial compounds in Brazilian propolis.
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