Owing to their remarkable thermal–hydraulic performance, vapor chambers have diverse applications, especially for cooling electronic devices. However, the performances of circular and noncircular pillars throughout the entire vapor chamber under identical wick volume conditions have been compared in very few studies. In this study, a series of noncircular pillar arrays featuring biomimetic tree-like fractal networks is introduced. The incorporation of fractal pillars significantly enhances the thermal–hydraulic performance of the vapor chamber because the gas–liquid interface area is extended. Compared to a vapor chamber with circular pillars, the maximum condensation surface temperature difference, total thermal resistance, and liquid pressure drop of this vapor chamber with fractal pillars are reduced by up to 57.8%, 13.8%, and 10.9%, respectively. In particular, with large branch levels and pillar diameters, the fractal structure is pivotal for boosting the overall performance. When the number of pillars is increased, the fractal structure's impact on the thermal performance reaches a limit, whereas its boosting effect on the flow performance weakens. This study is a pioneering exploration of the application of stretched geometries in pillar-type vapor chambers, with fractal pillars utilized in showcase demonstrations.