Ideal Source Research Articles

Type 3 Diabetes Mellitus, Insulin Resistance, Alzheimer’s Disease and Role of Alpha-Linolenic Acid in Blood–Brain Barrier Repair

Abstract Alzheimer’s disease (AD), is often referred to as Type 3 diabetes mellitus (T3 DM). It has now become evident that T3 DM contributes significantly to the pathogenesis of AD. The T3 DM has a distinct identity being very much selective for blood–brain barrier (BBB) and separated from peripheral diabetes. Alpha-linolenic acid (18:3, ALA) is considered an essential fatty acid that is responsible for the formation of long-chain eicosapentaenoic acid (20:5) and docosahexaenoic acid (22:6, DHA). DHA is an important structural fatty acid of the human brain. The recent literature comes to the conclusion that ALA is an ideal source of DHA. T3 DM can cause, insulin resistance in the brain and impairment in glucose utilization. This has very serious implications on BBB integrity. It has been shown now that ALA very efficiently can provide energy to endothelial cells of the BBB by β-oxidation and facilitate DHA entry to the brain. It has also been shown that some DHA is formed in BBB and some ALA that enters the brain also gets converted to DHA. The role of other players such as Apolipoprotein E protein, Tau and Beta-amyloid, and glycogen synthase kinase are briefly mentioned. The new findings, that the primary event in BBB damage is the pathogenesis of AD, may help in the development of new more effective drugs and treatment modalities.

Construction of asymmetric ceramic membranes with identical source interlayer on fly ash support by dip-coating

As a highly efficient separation technology, ceramic membranes have been widely applied. The use of fly ash to prepare low-cost ceramic membranes has garnered significant attention in recent years. However, challenges remain in the preparation of asymmetric ceramic membranes with high performance. This study presents an efficient approach to fabricating asymmetric ceramic membranes with an identical source interlayer on fly ash supports using the dip-coating method. The alumina selective layer was co-sintered with the optimized interlayer at 1000°C. The average pore size of the asymmetric ceramic microfiltration membrane was approximately 120 nm, and the pure water permeance reached 870 L·m−2·h−1·bar−1. The ceramic microfiltration membrane demonstrated high efficiency in separating oil-in-water emulsions, achieving a stable permeance of 130 L·m−2·h−1·bar−1 and a TOC removal rate above 99 %. This work provides an efficient and effective construction method for producing fly ash-based ceramic membranes with high performance.

Efficacy and Significance of Bio Choline as Choline Source in Poultry

Choline chloride, an organic, colorless, alkaline substance that is treated as a vitamin, though not a vitamin of B complex category, due to its multifaceted functions in animal husbandry too. Specifically, in Poultry where it seems to be the prime reason for hepatic health, apart from its role in the various metabolic and physiological activities. The economic importance of Choline in Poultry has led to the stocking up of innumerable number of its Synthetic forms in the market. These are hygroscopic, corrosive, offensive, off-flavored, non eco-friendly and in being inferior quality and working wise. This has led to an effort and search for alternatives, leading to Phytogenic Herbals as ideal sources. The Bio choline from Indigenous Indian herbs like Azardarictha, Achyranthes, Andrographis, Allium sativum, Fumaria, Solanum, Silibum, and Tachyspermum, was non hygroscopic, non-corrosive, non-off flavored and ecofriendly. The Bio choline equivalence of these herbs was as Phosphotidylcholine with a capability of replacing Synthetic choline completely with good quality and excellent working.

Perfect transmission through lossy layers via ideal acoustic sources

Complementary acoustic metamaterials (CAMMs) have been proposed as a means of enhancing the transmission of acoustic imaging signals through aberrating layers. Aberrating layers with high impedance contrast compared to the surrounding material disrupt the acoustic field and hence distort acoustic images. However, conventional CAMMs are passive and thus unable to compensate for signal distortions associated with loss. This work presents an approach inspired by CAMMs that is not bound by the limits of passivity to compensate for both acoustic scattering and energy attenuation by augmenting a plane wave incident on a lossy material with monopolar and dipolar source fields to allow for perfect transmission, thus rendering the lossy medium acoustically transparent. We present a general approach to derive expressions for source magnitudes that are dimensionless with respect to frequency, system geometry, and the background medium. We validate these results with three-dimensional finite element simulations, where the appropriate monopolar and dipolar source fields are generated by prescribing velocities on finite-dimensional boundaries. We show the limitations of this approach with regard to frequency, system geometry, and lossy material characteristics via a parametric study.

Preparation of LiLaZrMO (M= Ga/Al) solid electrolytes for thermal batteries

Thermal batteries (TBs) are ideal power sources for high temperature environment due to their high specific energy, long storage time, and quick activation. However, the common molten salt electrolytes (MSE) suffer from overflow under overload or high spin state, which could lead to short circuit of the batteries. To address this issue, LiLaZrMO (LLZMO, M = Ga/Al) doped with different elements are prepared. The doping elements result in the phase change of LiLaZrO (LLZO) from tetragonal to cubic, alters the distribution of Li atoms and increases the ion transport bottleneck sizes. In particular, LiLaZrGaO (LLZGO) has the lowest activation energy (0.3 eV) and the highest total conductivity (2.57 × 10−2 S cm−1 at 500 °C) owing to the larger bottleneck and unique Li+ transport channel. TB with LLZGO provides the highest discharge specific capacity of 368.5 mAh g−1 and lowest internal resistance (0.23 Ω cm−2). Compared with the ones using LiF–LiCl–LiBr MSE, TB with LLZGO solid electrolyte (SE) also shows superior performance in pulse discharge capabilities due to the stable internal resistance as well as the fluctuation free characteristics. Therefore, LLZGO SE holds great potential as viable alternative to MSEs in TBs.

Synthesis strategies, regeneration, cost analysis, challenges and future prospects of bacterial cellulose-based aerogels for water treatment: A review

Clean water is an integral part of industries, agricultural activities and human life, but water contamination by toxic dyes, heavy metals, and oil spills is increasingly serious in the world. Aerogels with unique properties such as highly porous and extremely low density, tunable surface modification, excellent reusability, and thermal stability can contribute to addressing these issues. Thanks to high purity, biocompatibility and biodegradability, bacterial cellulose can be an ideal precursor source to produce aerogels. Here, we review the modification, regeneration, and applications of bacterial cellulose-based aerogels for water treatment. The modification of bacterial cellulose-based aerogels undergoes coating of hydrophobic agents, carbonization, and incorporation with other materials, e.g., ZIF-67, graphene oxide, nanoparticles, polyaniline. We emphasized features of modified aerogels on porosity, hydrophobicity, density, surface chemistry, and regeneration. Although major limits are relevant to the use of toxic coating agents, difficulty in bacterial culture, and production cost, the bacterial cellulose aerogels can obtain high performance for water treatment, particularly, catastrophic oil spills.

Ambient Electroreductive Carboxylation of Unactivated Alkyl Chlorides and Polyvinyl Chloride (PVC) Upgrading.

Electrosynthesis of alkyl carboxylic acids upon activating stronger alkyl chlorides at low-energy cost is desired in producing carbon-rich feedstock. Carbon dioxide (CO2), a greenhouse gas, has been recognized as an ideal primary carbon source for those syntheses, and such events also mitigate the atmospheric CO2 level, which is already alarming. On the other hand, the promising upcycling of polyvinyl chloride to polyacrylate is a high energy-demanding carbon-chloride (C-Cl) bond activation process. Molecular catalysts that can efficiently perform such transformation under ambient reaction conditions are rarely known. Herein, we reveal a nickel (Ni)-pincer complex that catalyzes the electrochemical upgrading of polyvinyl chloride to polyacrylate in 95 % yield. The activities of such a Ni electrocatalyst bearing a redox-active ligand were also tested to convert diverse examples of unactivated alkyl chlorides to their corresponding carboxylic acid derivatives. Furthermore, electronic structure calculations revealed that CO2 binding occurs in a resting state to yield an η2-CO2 adduct and that the C-Cl bond activation step is the rate-determining transition state, which has an activation energy of 19.3 kcal/mol. A combination of electroanalytical methods, control experiments, and computational studies were also carried out to propose the mechanism of the electrochemical C-Cl activation process with the subsequent carboxylation step.

Reducing penumbral blur in computed tomography by learning the inverse finite focal spot model

Penumbral blur is one of the major limitations of the high spatial resolution micro-CT, due to a nonideal large focal spot. Penumbral blur hinders the ability to resolve small features that may only be a few pixels in size. Reducing the focal spot size by decreasing the x-ray tube power is a straightforward solution, but it leads to prolonged scan durations. In this paper, we propose to mitigate the penumbral blur by learning the inverse finite focal spot model. First, we derived the finite focal spot model that builds a relationship from the ideal point source projection to the finite focal spot projection. Based on the derived model, we numerically compute a paired projection dataset. Second, we utilized two neural networks—U-net, and convolution modulation-based U-net (CMU-net) —to learn the inverse finite focal spot model. The goal is to estimate the ideal point source projection from the actual finite focal spot projection. CMU-net, which introduces convolution modulation blocks into the contracting path of the U-net, is proposed to boost the robustness of the U-net. Finally, the standard filtered back-projection (FBP) is employed for reconstruction using the estimated ideal point projection. The experiments show that both U-net and CMU-net can effectively reduce the penumbral blur, whereas CMU-net demonstrates better performance on the real data. Experiments on real measured data demonstrate that CMU-net is more robust than U-net and can effectively resolve fine details. This method has great potential in improving the efficiency of micro-CT acquisition. It allows increasing the tube power since our method can computationally compensate for the blur caused by an increased focal spot size.

Left-turn queue spillback identification based on single-section license plate recognition data

Left-turn queue spillback occurs when the queue of left-turn or adjacent through traffic exceeds the channelized section's capacity, resulting in discharge flow breakdown and inefficient use of green time. License plate recognition (LPR) systems, which offer lane-based data on individual vehicle discharging, present an ideal data source for the identification of queue spillback. Therefore, this paper proposes a method for left-turn queue spillback identification using single-section LPR data. The proposed method involves defining 10 types of left-turn spillbacks based on the queuing status of the left-turn and adjacent through lanes. Then, a lightweight algorithm is proposed to estimate lane-based queue lengths. At last, a rule-based identification algorithm is developed to specify spillback types by considering the left-turn phasing, estimated queue lengths, and lane capacity. The empirical experiment demonstrates a promising accuracy of 87.28%. Additionally, simulations with five left-turn phasing schemes further validate the proposed method, averaging nearly 90% accuracy in identifying spillbacks.

Seafood independence is within reach: a multi-scale assessment of seafood self-reliance in the United States

As a vital source of nutrition, cultural identity, and economic activity, seafood has become one of the most globally traded commodities worldwide. However, increased concerns about food security, coupled with the disruptive effects of climate change, contagious diseases, and geopolitical conflict, are bringing acute attention to the need for food system transformation at multiple scales. Here, we investigate the United States’ potential to achieve seafood “independence” and maximize health benefits to the nation by integrating production, utilization, yield, and consumption data across seven regions of the United States and nationally over 50 years (1970–2021). Although the United States is the second largest importer of seafood worldwide, findings from this study show that self-reliance at the national level is achievable, though the ability of different subregions to meet demand is variable. Achieving greater seafood independence would require shifts in consumer behavior, investments in infrastructure, and continual adaptation in the face of climate change.

Hydrogen-assisted recycling of Nd-Fe-B magnets from the end-of-life audio products

The transition towards green and sustainable technologies has significantly increased the demand for a subset of raw materials known as critical elements. Rare earth elements with their main use in Neodymium-Iron-Boron magnets (NdFeB) play a key role in clean energy technologies including electric vehicles and wind turbine generators. They are also a key component in electronic devices including mobile phones, hard disk drives, and loudspeakers. Here, we build on previous knowledge of the recycling of NdFeB magnets from hard disk drives, using a hydrogen process called HPMS (Hydrogen Processing of Magnet Scrap). This study investigates a new scrap stream from loudspeakers, specifically from vehicles and flat-screen TVs. The extracted magnets from loudspeakers typically had grades of N30/N33 with relatively low coercivity values. The interactions of the extracted magnets with hydrogen were monitored by gravimetric and thermal analyses. The thermodynamics and kinetics of the hydrogenation reaction appear to differ significantly based on their chemical composition, chemical homogeneity, coating state, and surface condition of the magnets. Overall, the HPMS process was demonstrated to successfully produce demagnetised hydrogen decrepitated powder at room temperature under 2 bar of hydrogen, in a commercially viable timeframe (approx. 4 h). Zinc was found to be the dominant coating material which peeled away during the HPMS process. The zinc content of the NdFeB alloy powder could be reduced after the hydrogen decrepitation by sieving. The remaining level of zinc had no noticeable impact on the magnetic properties of the recycled magnets. The particle size of the recycled alloy powder could be reduced to below 7 µm by ball milling and knife milling but with an increase in the oxygen level, limiting its sintering ability. Sintered magnet from the recycled alloy powder demonstrated similar magnetic properties (Br: 1.06 T, HcJ: 1240 kA/m, and (BH)max: 220 kJ/m3) after blending with 5 wt% of NdH3, making vehicles and flat-screen TV speakers ideal sources for a recycled magnet.

Exploring the Essence, Importance, and Distinctive Attributes of Islamic Culture: An In-depth Cultural Analysis

Islamic culture is a testament to the rich tapestry of human civilization, interwoven with history, religion, philosophy, and art. This paper embarks on a comprehensive exploration of Islamic culture's essence, importance, and distinctive attributes through an in-depth cultural analysis. Drawing upon a qualitative research methodology, the study focuses on the historical development, religious foundations, artistic expressions, and societal norms within Islamic civilization. By synthesizing data from academic literature, primary sources, and expert interviews, the paper provides a nuanced understanding of Islam's historical and cultural dimensions, particularly in society. The research methodology employed involves a systematic review of relevant literature and primary documents, supplemented by interviews with experts in Islamic culture. The study emphasizes the importance of Islamic culture, not only for Muslims but also for humanity as a whole, serving as a source of spiritual guidance, moral framework, and cultural identity. Furthermore, the paper examines the salient characteristics of Islamic culture, including its emphasis on monotheism, diversity, social cohesion, and intellectual legacy. It underscores the significance of Islamic culture in fostering cross-cultural dialogue, promoting mutual respect, and shaping global perspectives. In conclusion, the study advocates for a deeper appreciation and understanding of Islamic culture's enduring legacy, calling for efforts to promote peace, justice, and understanding in our diverse and interconnected world.

Tough and elastic hydrogel thermocells for heat energy utilization

Hydrogel thermocells possess great potential in the energy conversion field as they directly absorb waste heat from the environment to drive redox reactions for continuous electricity generation. However, achieving high toughness and good elasticity simultaneously in hydrogel thermocells remains a challenge because of the inherent contradiction of energy dissipation mechanisms, severely limiting their practical applications and lifespan. To address this, a skin-like hydrogel network with a highly dense interwoven network is developed to construct hydrogel thermocells with good elasticity and high toughness. The dense network structure can effectively disperse the stress and hinder crack propagation, thus breaking the contradiction between high toughness and good elasticity. The thermocell realizes a toughness of 460 J m−2 while reaching an elastic limit strain of 350 %, far exceeding the elasticity of previous stretchable hydrogel thermocells. Meanwhile, it exhibits ultra-low hysteresis and excellent fatigue resistance under tensile and compressive cyclic loads. Moreover, the thermocell can work stably over long periods, enabling stable voltage output even under compression, bending, and stretching. In addition, the thermocell can power the LED lamp and calculator, and can also be connected in series to form large arrays, thus rendering it an ideal power source for wearable devices.

Utility of MALDI-TOF MS for determination of species identity and blood meal sources of primary malaria vectors on the Kenyan coast.

Protein analysis using matrix-assisted laser desorption/ionisation time-of-flight mass-spectrometry (MALDI-TOF MS) represents a promising tool for entomological surveillance. In this study we tested the discriminative power of this tool for measuring species and blood meal source of main Afrotropical malaria vectors on the Kenyan coast. Mosquito collections were conducted along the coastal region of Kenya. MALDI-TOF MS spectra were obtained from each individual mosquito's cephalothorax as well as the abdomens of blood-engorged mosquitoes. The same mosquitoes were also processed using gold standard tests: polymerase chain reaction (PCR) for species identification and enzyme linked immunosorbent assay (ELISA) for blood meal source identification. Of the 2,332 mosquitoes subjected to MALDI-TOF MS, 85% (1,971/2,332) were considered for database creation and validation. There was an overall accuracy of 97.5% in the identification of members of the An. gambiae ( An. gambiae, 100%; An. arabiensis, 91.9%; An. merus, 97.5%; and An. quadriannulatus, 90.2%) and An. funestus ( An. funestus, 94.2%; An. rivulorum, 99.4%; and An. leesoni, 94.1%) complexes. Furthermore, MALDI-TOF MS also provided accurate (94.5% accuracy) identification of blood host sources across all mosquito species. This study provides further evidence of the discriminative power of MALDI-TOF MS to identify sibling species and blood meal source of Afrotropical malaria vectors, further supporting its utility in entomological surveillance. The low cost per sample (<0.2USD) and high throughput nature of the method represents a cost-effective alternative to molecular methods and could enable programs to increase the number of samples analysed and therefore improve the data generated from surveillance activities.

87‐2: Modeling and Simulation for Mitigating Display Noise Caused by PMIC Ripple

The output ripple of the Power Management IC (PMIC) is one of the causes of display panel noise. This paper introduces modeling and simulation methods aimed at predicting and mitigating noise induced by PMIC ripple. If the display panel simulation is performed using an ideal voltage source, the ripple characteristics of the PMIC cannot be included. The improved method accurately predicted the ripple of the voltage input to the panel by modeling flicker noise and thermal noise, which are the main causes of PMIC noise, and modeling the Z‐parameter and decoupling capacitor of the PCB. In addition, it was possible to minimize ripples and finally reduce display noise by optimizing the design of the power supply circuit.

37Ar source on-demand production and deployment for low-energy nuclear recoil measurement in ReD liquid Argon TPC

The search for light dark matter (< 10 GeV/c 2) has become increasingly important, since no conclusive evidence has been found in the higher dark matter (DM) mass region. In order to explore this light mass range, it is necessary to accurately model the response of the noble liquid time projection chamber (TPC) detectors, used in many experiments aimed at the direct measurement of DM, to low energy (< 1 keV) nuclear recoils (NRs). In this respect, 37Ar provides an ideal calibration source in the low-energy region due to its two low-energy peaks at 0.27 and 2.82 keV following electron capture with a 35-day half-life. We propose a method to produce 37Ar without chemical or heating treatments by using the 40Ca(n,α)37Ar reaction. This can be achieved by irradiating nano-CaO powder with a neutron source (e.g. AmBe) and allowing the produced 37Ar to diffuse into the argon used inside a double-phase TPC. By measuring the NR yields relative to those two low-energy points in the Recoil Directionality (ReD) experiment, other detectors can be cross-calibrated with the same source deployed. In this talk, the 37Ar source production, its deployment, and preliminary results will be presented.

A Review of Antidiabetic Medicinal Plants as a Novel Source of Phosphodiesterase Inhibitors: Future Perspective of New Challenges Against Diabetes Mellitus.

Intracellular glucose concentration plays a crucial role in initiating the molecular secretory process of pancreatic β-cells through multiple messengers and signaling pathways. Cyclic nucleotides are key physiological regulators that modulate pathway interactions in β -cells. An increase of cyclic nucleotides is controled by hydrolysed phosphodiesterases (PDEs), which degrades cyclic nucleotides into inactive metabolites. Despite the undeniable therapeutic potential of PDE inhibitors, they are associated with several side effects. The treatment strategy for diabetes based on PDE inhibitors has been proposed for a long time. Hence, the world of natural antidiabetic medicinal plants represents an ideal source of phosphodiesterase inhibitors as a new strategy for developing novel agents to treat diabetes mellitus. This review highlights medicinal plants traditionally used in the treatment of diabetes mellitus that have been proven to have inhibitory effects on PDE activity. The contents of this review were sourced from electronic databases, including Science Direct, PubMed, Springer Link, Web of Science, Scopus, Wiley Online, Scifinder and Google Scholar. These databases were consulted to collect information without any limitation date. After comprehensive literature screening, this paper identified 27 medicinal plants that have been reported to exhibit anti-phosphodiesterase activities. The selection of these plants was based on their traditional uses in the treatment of diabetes mellitus. The review emphasizes the antiphosphodiesterase properties of 31 bioactive components derived from these plant extracts. Many phenolic compounds have been identified as PDE inhibitors: Brazilin, mesozygin, artonin I, chalcomaracin, norartocarpetin, moracin L, moracin M, moracin C, curcumin, gallic acid, caffeic acid, rutin, quercitrin, quercetin, catechin, kaempferol, chlorogenic acid, and ellagic acid. Moreover, smome lignans have reported as PDE inhibitors: (+)-Medioresinol di-O-β-d-glucopyranoside, (+)- Pinoresinol di-O-β-d-glucopyranoside, (+)-Pinoresinol-4-O-β-d-glucopyranosyl (1→6)-β-dglucopyranoside, Liriodendrin, (+)-Pinoresinol 4'-O-β-d-glucopyranoside, and forsythin. This review provides a promising starting point of medicinal plants, which could be further studied for the development of natural phosphodiesterase inhibitors to treat diabetes mellitus. Therefore, it is important to consider clinical studies for the identification of new targets for the treatment of diabetes.

Phase-matched third-harmonic generation in silicon nitride waveguides.

Third-harmonic generation (THG) in silicon nitride waveguides is an ideal source of coherent visible light, suited for ultrafast pulse characterization, telecom signal monitoring and self-referenced comb generation due to its relatively large nonlinear susceptibility and CMOS compatibility. We demonstrate third-harmonic generation in silicon nitride waveguides where a fundamental transverse mode at 1,596 nm is phase-matched to a TM02 mode at 532 nm, confirmed by the far-field image. We experimentally measure the waveguide width-dependent phase-matched wavelength with a peak-power-normalized conversion efficiency of 5.78 × 10-7 %/W2 over a 660-μm-long interaction length.

Urban identity versus national identity in the global city: Evidence from six European cities

AbstractThis study explores the prioritization of urban identity over national identity in the context of the global city. Scholars have extensively discussed the fragmentation of national identity among individuals in the globalized world, and the relative proliferation of other communal identities, whether more cosmopolitan or place‐based. As globalization gradually erodes the cultural distinctiveness of nation states, cities are revealed as arenas within which inhabitants nurture a particular collective character, which is used as an attractive source of local, communal belonging. Global cities, in particular, are a compelling case to inquire into the interplay between national and urban identity. Due to their relative independence vis‐à‐vis the state, the global city can promote the values shared by inhabitants while constituting significant competition for nation‐based self‐determination and providing a unique source of urban identity that is simultaneously cosmopolitan and place‐based.In this paper we ask whether city‐zens living in highly globalized cities are more likely to prioritize their urban identity over their national identity. Utilizing the GaWC Index of cities’ globalization levels, we analyze the results of an original survey conducted among residents of six European cities: Paris, Madrid, Barcelona, Berlin, Utrecht and Glasgow. Our empirical evidence supports the hypothesis that in globalized cities a higher level of globalism accords with a more explicit tendency to prioritize urban identity over national identity. In conclusion, we interpret this evidence as an identities trade‐off that challenges the coexistence of urban and national identities within globalized cities, discussing its implications for future studies of contemporary politics.

Human amniotic epithelial stem cell is a cell therapy candidate for preventing acute graft-versus-host disease.

Graft-versus-host disease (GVHD), an immunological disorder that arises from donor T cell activation through recognition of host alloantigens, is the major limitation in the application of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Traditional immunosuppressive agents can relieve GVHD, but they induce serious side effects. It is highly required to explore alternative therapeutic strategy. Human amniotic epithelial stem cells (hAESCs) were recently considered as an ideal source for cell therapy with special immune regulatory property. In this study, we evaluated the therapeutic role of hAESCs in the treatment of GVHD, based on our previous developed cGMP-grade hAESCs product. Humanized mouse model of acute GVHD (aGVHD) was established by injection of huPBMCs via the tail vein. For prevention or treatment of aGVHD, hAESCs were injected to the mice on day -1 or on day 7 post-PBMC infusion, respectively. We showed that hAESCs infusion significantly alleviated the disease phenotype, increased the survival rate of aGVHD mice, and ameliorated pathological injuries in aGVHD target organs. We demonstrated that hAESCs directly induced CD4+ T cell polarization, in which Th1 and Th17 subsets were downregulated, and Treg subset was elevated. Correspondingly, the levels of a series of pro-inflammatory cytokines were reduced while the levels of the anti-inflammatory cytokines were upregulated in the presence of hAESCs. We found that hAESCs regulated CD4+ subset polarization in a paracrine mode, in which TGFβ and PGE2 were selectively secreted to mediate Treg elevation and Th1/Th17 inhibition, respectively. In addition, transplanted hAESCs preserved the graft-versus-leukemia (GVL) effect by inhibiting leukemia cell growth. More intriguingly, hAESCs infusion in HSCT patients displayed potential anti-GVHD effect with no safety concerns and confirmed the immunoregulatory mechanisms in the preclinical study. We conclude that hAESCs infusion is a promising therapeutic strategy for post-HSCT GVHD without compromising the GVL effect. The clinical trial was registered at www.clinicaltrials.gov as #NCT03764228.