Ideal Profile Research Articles

Ideal micro-lenticular lens based on phase modulation of optically isotropic liquid crystal-polymer composite with three terminals

Optical phase modulation in a transparent polymer film composed of nano-sized liquid crystal (LC) droplets embedded within a polymer matrix exhibits a micro-lenticular lensing effect under controlled in-plane field switching (IPS) with interdigitated electrodes. Despite of the lensing effect, the lens profile does not match ideal one and its effective phase modulation is relatively small owing to the weak field strength over the electrodes, which causes an invariant refractive index in these regions. To achieve ideal lens profile and high phase modulation, a vertical electric field is applied between top plane and bottom interdigitated electrodes, while maintaining the in-plane fields between the bottom interdigitated electrodes. The combined effect, referred to as the vertical and in-plane switching (VIS) mode, can achieve larger phase modulation (Δδ) than the IPS mode. Consequently, the proposed micro-lenticular lens has a shorter focal length and a significantly better lens profile, similar to the ideal one. Furthermore, the diffraction efficiency (Df) is effectively improved by ∼ 6.7%, 4%, and 2% for the zeroth (0th), ±1st, and ± 2nd orders, respectively, compared to those in the IPS mode. The improved phase profile with the proposed micro-lenticular device can be used in a switchable lens from 2-dimensions (2D) to 3-dimension (3D) and tunable diffractors.

How Similar are the Dentoskeletal Characteristics of Class III Double-Jaw Surgery Patients with Ideal Post- Treatment Profiles and Class I Subjects?

To define the dental and skeletal characteristics of Class III surgery patients with ideal final soft-tissue profiles, and to compare them with those of Class I subjects. Also, to show how soft-tissues respond to surgical jaw movements and contribute to the outcome. This short-term, retrospective study was conducted using pre-treatment (T0), pre-surgery (T1), and post-treatment (T2) records of 50 double-jaw Class III surgery patients who presented with ideal cephalometric characteristics in sagittal (Holdaway and soft-tissue convexity angles) and vertical dimensions (GoGn. SN angle and upper-to-lower face harmony) at the end of treatment, and 50 control subjects. At T2, the horizontal distance between the vertical reference plane (a perpendicular plane to the horizontal reference plane that is angulated 7° clockwise to the SN plane) and hard-tissue A, B and Pog points, lower lip, soft-tissue B, and pogonion points were greater, Wits appraisal was more negative, U1.PP was higher, IMPA was lower, and soft-tissue chin (Pog-Pog') was thicker in Group 1 when compared to Group 2 (p<0.05). Moreover, upper lip and subnasal (A-A') thicknesses were decreased, and chin thickness (Pog-Pog') was increased significantly (p<0.05). Dentoskeletal characteristics of an ideally-treated Class III surgery patient differed from a Class I subject concerning a protrusive maxilla and soft-tissue pogonion, and incisors that were not fully-decompensated. Soft-tissues hindered the actual surgical correction to 66% and 73% in the mid- and lower-faces, respectively.

Differentiating Abnormal, Normal, and Ideal Personality Profiles in Multidimensional Spaces

Abstract: Current dimensional taxonomies of personality disorder (PD) establish that intense traits do not suffice to diagnose a disorder, and additional constructs reflecting dysfunction are required. However, traits appear able to predict maladaptation by themselves, which might avoid duplications and simplify diagnosis. On the other hand, if trait-based diagnoses are feasible, it is the whole personality profile that should be considered, rather than individual traits. This takes us into multidimensional spaces, which have their own particular – but poorly understood – logic. The present study examines how profile-level differences between normal and disordered subjects can be used for diagnosis. The Dimensional Assessment of Personality Pathology – Basic Questionnaire (DAPP-BQ) and the Personality Inventory for DSM-5 (PID-5) were administered to a community and a clinical sample each (total n = 1,925 and 3,543 respectively). Intense traits proved to be common in the general population, so empirically-based thresholds are indispensable not to take as abnormal what is at most unideal. Profile-level parameters such as Euclidean and Mahalanobis distances outperformed individual traits in predicting mental problems and equaled the performance of published measures of dysfunction or severity. Personality profiles can play a more central role in identifying disorders than is currently acknowledged, provided that adequate metrics are used.

Antitumor activity of the PI3K δ-sparing inhibitor MEN1611 in PIK3CA mutated, trastuzumab-resistant HER2 + breast cancer

PurposeDysregulation of the PI3K pathway is one of the most common events in breast cancer. Here we investigate the activity of the PI3K inhibitor MEN1611 at both molecular and phenotypic levels by dissecting and comparing its profile and efficacy in HER2 + breast cancer models with other PI3K inhibitors.MethodsModels with different genetic backgrounds were used to investigate the pharmacological profile of MEN1611 against other PI3K inhibitors. In vitro studies evaluated cell viability, PI3K signaling, and cell death upon treatment with MEN1611. In vivo efficacy of the compound was investigated in cell line- and patient-derived xenografts models.ResultsConsistent with its biochemical selectivity, MEN1611 demonstrated lower cytotoxic activity in a p110δ-driven cellular model when compared to taselisib, and higher cytotoxic activity in the p110β-driven cellular model when compared to alpelisib. Moreover, MEN1611 selectively decreased the p110α protein levels in PIK3CA mutated breast cancer cells in a concentration- and proteasome-dependent manner. In vivo, MEN1611 monotherapy showed significant and durable antitumor activity in several trastuzumab-resistant PIK3CA-mutant HER2 + PDX models. The combination of trastuzumab and MEN1611 significantly improved the efficacy compared to single agent treatment.ConclusionsThe profile of MEN1611 and its antitumoral activity suggest an improved profile as compared to pan-inhibitors, which are limited by a less than ideal safety profile, and isoform selective molecules, which may potentially promote development of resistance mechanisms. The compelling antitumor activity in combination with trastuzumab in HER2 + trastuzumab-resistant, PIK3CA mutated breast cancer models is at the basis of the ongoing B-Precise clinical trial (NCT03767335).

Analysis of Teacher Performance in the Context of Successful Implementation of the Pancasila Student Profile Program at SDN 04 Birugo, Bukittinggi City

The author sees a gap or discrepancy between the expected ideal conditions and the existing reality. The ideal condition in question is a condition where young teachers have high performance. High teacher performance can be said to be an ideal teacher figure at school. This study aims to analyze teacher performance in the framework of the success of Pancasila Student Profiles in Elementary Schools in the City of Bukittinggi. This type of research is qualitative with the objects studied at SDN 04 namely the principal, teachers, and students. Data collection techniques were carried out in 3 ways, namely interviews, document review, and observation. The data analysis technique in the form of 3 (three) stages, namely (1) data display, (2) data reduction, and (3) conclusion. The results of the study show that basically the implementation of the Pancasila student profile program at SDN 04 Birugo, Bukittinggi City has been going well. But regarding the achievement results are still not optimal, which are described as follows; (1) The quality of teacher work is not optimal in implementing Pancasila student profiles. This is due to the not optimal cooperation between teachers and the timeliness of implementation which is measured according to the length of time it takes to achieve it compared to the target plan. (2) the factors that influence teacher performance in implementing the Pancasila student profile are the leadership factor of the school principal, the teacher's motivating factor towards an ideal teacher profile, factors of facilities and infrastructure and cooperation factors among teachers based on coordination and synergy. (3) The principal's efforts in improving teacher performance to improve the implementation of Pancasila student profiles are to motivate individual teachers to develop cooperative attitudes among teachers and to take a persuasive and democratic approach by applying a type of transformative leadership in issuing policies.

New Perspectives for Human and Artificial Intelligence Interactions for Leadership e-Recruitment

In order to adapt to the post-pandemic era, e-recruitment systems should change their requirements to search for a more competitive leader profile. These systems currently search for individual skills specific to leaders, taking into consideration whether a leader has the required skills and abilities for a certain job. The aim of this study is to improve e-recruitment searches for capable leaders in this new environment. In this regard, the study proposes to search for combinations of complementary skills. These skills, to be effective, should necessarily support each other in order to create successful management. The author’s proposal is to call this combination of skills: Leadership Complementary Skills (LCS). Understanding that some skills should be complementary in order to be viable, the LCS’ new insight into the hiring process was developed to comply with the aim of a performant organization. The idea was drawn from the author’s half a century of real-world experience and from several discussions with employers, employees, consultants and MBA students, debating cases along working and teaching. Statements are presented regarding proposals of appropriate combinations of skills to be implemented in the software of e-recruitment systems, their influence on employees’ behavior and the possible consequences on organizational outcomes. Consistent with the proposals, the author has also developed the Honeycomb Complementary Skills Model for Leadership as a first step in this endeavor, inviting future researchers to find other LCS to be added to the model and accomplish the actual ideal profile of a leader, opening as such a new field of research.

Executive functions and psycho-behavioural skills in artistic gymnasts: age, developmental stage and sex-related differences

ABSTRACT During the talent development (TD) process in sport, cognitive and psycho-behavioural skills are necessary to successfully overcome TD-specific challenges. This cross-sectional study explored executive functions (EF) and psycho-behavioural skills (PCDE), in male and female high-level artistic gymnasts between 9 and 26 years old. The first objective was to investigate if an ideal profile would emerge for these gymnasts. In the youngest age group (9–12yo), a general improvement with age for EF was observed, and gymnasts scored higher on imagery use than the quasi-control group. The older age group showed that gymnasts had significantly higher scores on inhibition, imagery use and self-directed control and management than the quasi-control group. The second objective was to conduct a person-centred approach, investigating the individual profiles of a selected group of four high-level gymnasts. The radar charts revealed a relatively similar profile in all four gymnasts and the quasi-control group for the EF components, while there was a pronounced within group and between groups variation for the PCDE profiles. This study showed that inhibition, imagery use and self-directed control and management could be potential performance indicators in gymnastics. The radar charts support the idea that, once an athlete scores above a specific threshold on all variables, there is no necessity for trying to maximise each and every of these skills but rather, it might be better to leave room for individual profile variation. Since individually different profiles were indeed observed, we recommend an athlete-centred approach in all TD phases from a young age onwards.

The Profile of Palaeontology Teaching in Undergraduate Courses in Brazil

Background: Currently, palaeontology professors have been challenged to update and incorporate innovative teaching approaches into their planning to help students develop the necessary skills and competencies. However, today there is a mismatch between the current and the ideal teaching profiles. Objective: To describe the palaeontology teaching profile in undergraduate courses in Brazil. Design: Descriptive and exploratory study. Setting and participants: Palaeontology professors (n=37) in undergraduate courses at several Brazilian higher education institutions. Data analysis collection: Data were collected through a semi-structured online form (survey), triangulated and categorised into (a) general characteristics, (b) teacher education, (c) teaching experience, (d) undergraduate courses, (e) curriculum, syllabus, and programme discussion meetings, (f) inter and multidisciplinarity, and (g) curriculum. Results: Despite the limited scope (small sample size), the study results guided the focus of the research and improvement efforts, as there are still many difficulties and challenges to be overcome to raise the quality of teaching in undergraduate palaeontology across the country. Conclusions: The data from this study can serve as a valuable basis for professors-researchers, educational managers, and policymakers interested in implementing innovative continuing education programmes and in supporting management and policy decisions regarding potential reforms of palaeontology teaching in Brazilian undergraduate courses in higher education institutions.

Cardiovascular health profiles, systemic inflammation, and physical function in older adults: A population-based study

We examined the association of modifiable cardiovascular health (CVH) metrics with physical function among rural older adults in China and the potential role of inflammatory mechanisms in the association. This study included 3733 stroke- and dementia-free participants (age ≥65 years; 56.9% women) in the baseline survey of a multimodal intervention study in rural China. From March-September 2018, data were collected via face-to-face interviews, clinical assessments, and laboratory tests. The Short Performance Physical Battery (SPPB) test was performed to assess physical function. We defined six modifiable CVH metrics according to the modified American Heart Association's recommendations. Serum interleukin (IL)-6 was measured in a subsample (n = 1156). Data were analyzed with multiple general linear and logistic regression models and structural equation modeling. Poor physical function (SPPB score ≤9) was defined in 1443 participants. Ideal CVH (vs. poor CVH) was associated with multivariable-adjusted odds ratio of 0.60 (95%CI 0.48–0.75) for poor physical function. Ideal CVH was significantly associated with higher scores on balance, chair stand, and walking speed tests (all p < 0.05). Moreover, ideal CVH profile was associated with lower serum IL-6 (multivariable-adjusted β=-0.04; 95% CI -0.06, -0.01). Mediation analysis revealed that serum IL-6 accounted for 14% of the association of CVH with total SPPB score and 10% of the association with walking speed score (p < 0.05). This study suggests that an ideal CVH profile is associated with better physical function among stroke- and dementia-free older adults, partly via inflammatory mechanisms. The preventive implications of these findings warrant further investigation in cohort studies.

Few-Layered Hexagonal Boron Nitrides as Highly Effective and Stable Solid Adsorbents for Ammonia Separation

Solid adsorbents with high NH3 separation performance and good stability are particularly important for industrial applications. In our work, few-layered hexagonal boron nitrides (h-BNs) were synthesized and proposed as a kind of solid adsorbent by utilizing the abundant Lewis acidic B atoms on h-BNs. The synthesized h-BNs were investigated for NH3 separation both experimentally and theoretically. It is found that the NH3 isotherms of h-BNs slightly deviate from the ideal profiles, suggesting that the h-BNs enable moderate interactions with NH3. At the pressure of 0.1 and 1 bar, the h-BNs can adsorb as much as 2.33 and 8.67 mmol/g of NH3, respectively. The h-BNs also demonstrate highly selective adsorption of NH3 from other gases such as N2, H2, and CO2, regardless of calculated ideal selectivities or breakthrough adsorption of mixed gases. The NH3 adsorption of h-BNs can be completely reversed, and the h-BNs also exhibit high oxidative resistance, which is of vital importance for the long-term application in industry. Density functional theory calculations and molecular dynamics simulations were further conducted to rationalize the effective separation of NH3 by h-BNs and disclose the underlying mechanism at the molecular level.

Connecting Feelings of School Belonging to High School Students’ Friendship Quality Profiles

Utilizing a person-centered approach, the present study explored 614 adolescents’ reports of self-disclosure, help, conflict, and conflict resolution with a close friend to investigate variability in profiles of friendship quality, whether gender and gender homophily and ethnicity homophily of friends are associated with profile membership, and how the profiles relate to feelings of school belonging. A latent profile analysis revealed three profiles of friendship: an ideal friendship profile (25.57% of the sample), a realistic friendship profile (54.56%), and a somewhat problematic friendship profile (19.87%). Compared to adolescents in the somewhat problematic profile, female adolescents were more likely to have a realistic or ideal friendship profile than males. Adolescents with ideal and realistic friendship profiles reported the highest feelings of school belonging; those in the somewhat problematic profile reported the lowest school belonging. The advantages of attending to profiles that incorporate multiple dimensions of friendship quality to understanding the social and academic experiences of adolescents are discussed.

Sea Surface Wind Structure in the Outer Region of Tropical Cyclones Observed by Wave Gliders

AbstractUnderstanding the sea surface wind structure during tropical cyclones (TCs) is the key for study of ocean response and parameterization of air‐sea surface in numerical simulation. However, field observations are scarce. In 2019, three wave gliders were deployed in the South China Sea and the adjacent Western Pacific region, which acquired sea surface wind structure of eight TCs. Analysis of the field data suggests that the wave glider‐observed surface winds are consistent with most analysis/reanalysis data (i.e., ERA5, Cross‐Calibrated Multi‐Platform, and National Centers for Environmental Prediction‐Global Data Assimilation System) and Soil Moisture Active Passive. Both wave glider observations and analysis/reanalysis data indicate that TC wind fields induce an obvious increase in speed toward the sea surface together with a sharp change in direction, showing an asymmetric wind structure which is sensitive to TC translation speed and intensity. Larger mean values of wind speed and inflow angle are located on the right side along TC tracks. The inflow angle shows a highly dynamic dependence on the radial distance from the TC center, the TC intensity, as well as the TC‐relative azimuth. Comparisons between field observations and theoretical models indicate that the most widely used, ideal TC wind profile models can largely represent the observed sea surface wind structure, but generally underestimate the wind speed due to lack of consideration of background wind. Moreover, simple ideal models (e.g., the modified Rankine vortex model) may outperform complex models when accurate information of TCs is limited. Wave glider observations have potential for better understanding of air‐sea exchanges and for improvements of the corresponding parameterization schemes.

Reducing dietary crude protein in broiler diets positively affects litter quality without compromising growth performance whereas a reduction in dietary electrolyte balance further improves litter quality but worsens feed efficiency

Reducing crude protein (CP) in broiler feed is a nutritional strategy that allows to partially reduce dietary soybean meal (SBM) inclusions to reduce feed costs, with proven benefits. In addition, reduction of dietary CP leads to a lower dietary electrolyte balance (dEB) due to the concomitant reduction of potassium (K). The aim of the present study is therefore two-fold: 1) to evaluate the potential of reduction of dietary CP until performance drops (1, 2 or 3 % points of reduction) and 2) to combine it with a reduction of dEB (by reducing dietary K) to validate the benefit of reduced dEB/K on litter quality without compromising performance. In total, 9100 male Ross 308 chicks were randomly allotted to 35 pens of 260 broilers. They were fed 5 dietary treatments from 10 to 20d and 20–30d.There was a “positive control” diet (CONTROL; 20.7 % CP in grower, 19.5 % CP in finisher) and 3 levels of dietary CP reduction by 1 % (CP-1 %), 2% (CP-2 %) and 3 % (CP-3 %), all diets formulated to respect at least the ideal AA profile for indispensable AA. In addition, an extra diet called “negative control” (NC CP-3 %) was formulated to have the same ingredient composition as the CP-3 % diet but with lower K and dEB level. Reducing dietary CP as low as 3 % points and maintaining AA and dEB levels resulted in similar or better production performance from 10 to 30d for weight gain, feed intake, feed conversion ratio (FCR) and carcass traits, reduced daily water intake and water-to-feed ratio, excreta N and moisture as well as lower litter moisture and footpad lesions (FPL). Reducing dEB level at − 3 % CP (negative control) increased feed intake and FCR but reduced water intake, water-to-feed ratio, and FPL. It is therefore possible to feed broilers with lower CP diets without compromising performance, with clear benefit on litter quality. As reducing dietary CP is often associated to reduced dietary K, due to lower SBM inclusion, the extent of reduction of K and the control of dEB by Na, Cl and K need to be further explored, especially on litter quality, to facilitate the adoption of low protein diets in practice.

Current Trends in Ideal Nasal Aesthetics Show Younger Patients Have a Preference Toward Longer Augmented Noses.

Aesthetic norms fluctuate over time and often result in generational differences in preferred ideal nasal aesthetics. While some traditional concepts of the ideal nasal aesthetic have been suggested in our literature, there has been no study to date that has identified contemporary preferences across different age groups. To understand the general population's current perception of ideal nasal profiles. Two-dimensional images of female noses (n = 10) of varying ethnicities were simulated to alter either the radix height or nasolabial angle (NLA) independently. Radix height was manipulated by increasing or decreasing the height by 5 mm relative to baseline. For NLA, 3 images were created with the following measurements: (1) 90°, (2) 100°, and (3) 110°. Groups were categorized by generation and age at the time of completing the study: Generation Z (Gen Z; age 18-23), Millennial 20s (age 24-30), Millennial 30s (age 31-39), and Generation X (Gen X; age 40-55). Each figure consisted of either 3 variations in radix height (n = 10) or 3 variations in NLA (n = 10). Within each figure, volunteers were asked to choose their preferred nose. The younger generations, Gen Z and Millennial 20s and 30s, preferred a more augmented radix compared to Gen X which preferred a baseline radix height. Gen Z, Millennial 20s, and Gen X preferred a 90° NLA, while Millennial 30s preferred an NLA of 100°. The authors found that younger populations (Gen Z, Millennial 20s, and Millennial 30s) preferred a more augmented appearance to the nasal radix and, on average, a more acute NLA than published data suggest.

Chitosan-coated ultrapure silicon nanoparticles produced by laser ablation: biomedical potential in nano-oncology as a tumor-targeting nanosystem.

Ultrapure silicon nanoparticles (SiNPs) produced by femtosecond laser ablation in water have attracted great interest in the area of cancer therapy as they are efficient as photosensitizers in photodynamic therapy modality and can induce cell hyperthermia under radiofrequency radiation. Recently, we showed that these biocompatible nanoparticles were not able to reach tumors after intravenous injection in mice due to their rapid clearance from the bloodstream. In order to increase their half-life time and therefore their chances to reach and accumulate in tumors by an enhanced permeation retention (EPR) effect, a capping agent on SiNP surface acting as a colloidal stabilizer suspension is required. In this regard, this work focuses for the first time on the functionalization of SiNPs through the modification of their surface by chitosan (SiNPs-CH) in order to enhance their therapeutic properties in cancer therapy. Here, in vivo experiments were carried out during 15 days on nude mice developing a subcutaneously grafted malignant human brain tumor (glioblastoma). The characterization of SiNPs-CH showed an average hydrodynamic size of around 142 ± 65 nm as well as a relatively neutral charge (-5.2 mV) leading to a high colloidal suspension stability. The point of our work concerns the improvement of the biodistribution of SiNPs-CH with regard to tumors, the bloodstream, and organs. After the intravenous administration of 20 mg kg-1, all the studied parameters (animal behavior, organs' morphology, and histopathology) were in accord with the absence of toxicity due to SiNPs-CH, confirming their biocompatibility and even size and surface charge were modified compared to bare nanoparticles. Moreover an increased time in the bloodstream circulation of up to 7 days was observed, indicating the stealth of the nanoparticles, which could escape opsonization and premature elimination by macrophages and the reticuloendothelial system. As evidenced by silicon assessment, the interaction of the SiNPs-CH with the liver and spleen was significantly reduced compared to the bare nanoparticles. At the same time, SiNPs-CH were concentrated progressively in tumors from 12.03% after 1 day up to 39.55% after 7 days, confirming their uptake by the tumor microenvironment through the enhanced permeability retention effect. Subsequently, the silicon level declined progressively down to 33.6% after 15 days, evidencing the degradation of pH-sensitive SiNPs-CH under the acidic tumor microenvironment. Taken together, the stealthy SiNPs-CH exhibited an ideal biodistribution profile within the tumor microenvironment with a sustainable biodegradation and elimination profile, indicating their promising application in the nano-oncology field as a tumor-targeting system.

A fundamental investigation of the interaction and impact of controlled torque ripples on gear mesh dynamics

Gear trains are plagued by self-excited vibrations that are concentrated at the mesh frequency and its harmonics due to their varying mesh stiffness and deviations from the ideal involute profile. This is even more pronounced in spur gears due to their lower contact ratio in comparison to helical gears. For an electric vehicle, due to the absence of an internal combustion engine, noise and vibration signature of the gearbox becomes an important aspect of the vehicle's comfort. However, the presence of a traction motor offers the advantage of having a potential actuator for actively countering these vibrations without adding any additional weight or packaging constraints. This paper presents a fundamental insight into the effect of introducing controlled torque ripples at the mesh frequency and its harmonics, on the noise and vibration characteristics, and the efficiency of the gear mesh. The study utilises a dynamic model of a single stage gear train that accounts for the time varying mesh stiffness and sliding friction at the gear teeth contact. This model is used to provide an understanding of gear mesh dynamics and their resulting interaction with the imposed torque ripples. The study demonstrates the positive effects that controlled torque ripples can have on the noise and vibration behaviour of gear trains and the underlying mechanics that govern this improvement.

Small-molecule inhibitors of bacterial-producing metallo-β-lactamases: insights into their resistance mechanisms and biochemical analyses of their activities.

Antibiotic resistance (AR) remains one of the major threats to the global healthcare system, which is associated with alarming morbidity and mortality rates. The defence mechanisms of Enterobacteriaceae to antibiotics occur through several pathways including the production of metallo-β-lactamases (MBLs). The carbapenemases, notably, New Delhi MBL (NDM), imipenemase (IMP), and Verona integron-encoded MBL (VIM), represent the critical MBLs implicated in AR pathogenesis and are responsible for the worst AR-related clinical conditions, but there are no approved inhibitors to date, which needs to be urgently addressed. Presently, the available antibiotics including the most active β-lactam-types are subjected to deactivation and degradation by the notorious superbug-produced enzymes. Progressively, scientists have devoted their efforts to curbing this global menace, and consequently a systematic overview on this topic can aid the timely development of effective therapeutics. In this review, diagnostic strategies for MBL strains and biochemical analyses of potent small-molecule inhibitors from experimental reports (2020-date) are overviewed. Notably, N1 and N2 from natural sources, S3-S7, S9 and S10 and S13-S16 from synthetic routes displayed the most potent broad-spectrum inhibition with ideal safety profiles. Their mechanisms of action include metal sequestration from and multi-dimensional binding to the MBL active pockets. Presently, some β-lactamase (BL)/MBL inhibitors have reached the clinical trial stage. This synopsis represents a model for future translational studies towards the discovery of effective therapeutics to overcome the challenges of AR.

Historical Transformation of the Ideal Citizen Profile in Turkey (1789-1938)

Historical Transformation of the Ideal Citizen Profile in Turkey (1789-1938)

Strategy to define the profile of excellence of a commercial talent, as a competitive advantage of human capital for a leading company in northern Mexico

The human capital represents, without a doubt, an indispensable force to increase productivity and efficiency in companies overseas. The objective was to define a profile of excellence for talents who can participate in a leading company in northern Mexico. A second objective was to prepare a judgment of the company regarding its recruitment and personnel selection procedure. The parameters were qualitative and a questionnaire with open questions was used as a data collection instrument. The ideal profile for each position was identified considering previous experience, academic training, skills, and even intangible variables such as the company's organizational culture. The coordination of the candidate's work area and the recruitment area, as well as the selection of personnel, was analyzed. The priority of company employees to fill their vacancies over external candidates was considered. In addition, a structuring of a competency model was pondered. The results showed that in the selection process, the verification of the information provided in the resume, such as personal and work references, is emphasized.

Integrasi Metode Kano dan Turf dalam Evaluasi Sensori Minuman Cokelat Instan Komersial

Sensory attribute is one of quality parameter that affects buying intention of consumer for commercial instant chocolate drink product. Evaluation of consumer liking using hedonic method or ideal profile method was not enough to fulfill consumer satisfaction. This research aims to identify sensory attributes which are able to give consumer satisfaction using survey method integrated with structural equation model (SEM), Kano method, and total unduplicated reach and frequency (TURF). Kano method is used to evaluate sensory attributes based on consumer satisfaction, while TURF is used to identify sensory component which is able to increase buying intention of consumers with regard to the range and frequency for chocolate instant commercial drink. Preliminary research conducted by modelling consumer preferences suggested that there was an influence of 0.76 sensory attributes to consumer satisfaction. Seven samples were purchased from market and evaluated by 30 untrained panelists using home use test with an approach of consumer habit to consume hot chocolate drink once a week. The panelists were chosen from people who consume commercial instant chocolate drink. Results of this research showed that sensory attributes creamy (texture) and dark chocolate (color) were attractive features which were able to improve consumer satisfaction. Atribute sweet (taste) was categorized as must-be features, while flavor, aroma, and color were classified as one-dimensional features. Combination of attributes in one category can improve the range to reach the targeted consumers and frequency of consumers towards the product, for example attribute creamy can reach 97%, but combination of attributes creamy and thickness can reach 100% of the targeted consumers.