Ideal Physical Properties Research Articles

Evaluation of Surface Quality and Productivity in Conventional Milling of Copper Beryllium Using Minimum Quantity Lubrication

Copper Beryllium (C17200) has ideal physical and mechanical properties of high fatigue strength, thermal conductivity, and hardness, making the alloy ideal for various high-reliability applications in aerospace, producing inserts and tooling for hazardous environments. However, surface quality and productivity challenges are prominent when processing the alloy due to its properties. This study evaluates the surface quality and productivity in end-milling of Copper Beryllium by analyzing the effects of feed rate, minimum quantity lubrication (MQL) flow rate, and cutting depth on surface roughness (Ra) and material removal rate (MRR). The experiment was designed using the Box-Behnken design, and the samples were machined on a CNC milling machine. The results showed that the MQL flow rate was significant to surface roughness, while the cutting depth was significant to MRR. The optimum parameters were determined as a feed rate of – 60 mm/min, an MQL flow rate of – 80 ml/hr., and a cutting depth of – 0.511 mm, which yielded a surface roughness of 0.12 µm and MRR of 10.19 g/min. The study's novelty is that it considers MQL flow using vegetable oil-based cutting fluid (CF) as an input parameter in machining, offering insight into eco-friendly and cost-effective machining practices. Finally, the significance of the study lies in investigating the machinability of Cu-Be alloy material, addressing challenges related to surface quality and productivity during milling operation.

Orally Bioavailable Proteolysis-Targeting Chimeras: An Innovative Approach in the Golden Era of Discovering Small-Molecule Cancer Drugs.

Proteolysis-targeting chimeras (PROTACs) are an emerging therapeutic modality that show promise to open a target space not accessible to conventional small molecules via a degradation-based mechanism. PROTAC degraders, due to their bifunctional nature, which is categorized as 'beyond the Rule of Five', have gained attention as a distinctive therapeutic approach for oral administration in clinical settings. However, the development of PROTACs with adequate oral bioavailability remains a significant hurdle, largely due to their large size and less than ideal physical and chemical properties. This review encapsulates the latest advancements in orally delivered PROTACs that have entered clinical evaluation as well as developments highlighted in recent scholarly articles. The insights and methodologies elaborated upon in this review could be instrumental in supporting the discovery and refinement of novel PROTAC degraders aimed at the treatment of various human cancers.

A personalized biomimetic dual-drug delivery system via controlled release of PTH1-34 and simvastatin for in situ osteoporotic bone regeneration.

Patients with osteoporosis often encounter clinical challenges of poor healing after bone transplantation due to their diminished bone formation capacity. The use of bone substitutes containing bioactive factors that increase the number and differentiation of osteoblasts is a strategy to improve poor bone healing. In this study, we developed an in situ dual-drug delivery system containing the bone growth factors PTH1-34 and simvastatin to increase the number and differentiation of osteoblasts for osteoporotic bone regeneration. Our system exhibited ideal physical properties similar to those of natural bone and allowed for customizations in shape through a 3D-printed scaffold and GelMA. The composite system regulated the sustained release of PTH1-34 and simvastatin, and exhibited good biocompatibility. Cell studies revealed that the composite system reduced osteoblast death, and promoted expression of osteoblast differentiation markers. Additionally, by radiographic analysis and histological observation, the dual-drug composite system demonstrated promising bone regeneration outcomes in an osteoporotic skull defect model. In summary, this composite delivery system, comprising dual-drug administration, holds considerable potential for bone repair and may serve as a safe and efficacious therapeutic approach for addressing bone defects in patients with osteoporosis.

A simplified and efficient preparation process of pineapple leaf fibers via in-situ retting and degumming by Bacillus subtilis XW-18

Pineapple leaves are agricultural waste but rich in the pineapple leaf fiber (PALF) with superior mechanical properties. The conventional PALF preparation usually include two steps of manual/mechanical extraction and chemical degumming, resulting in adverse issues such as fiber loss, inferior fiber quality, and environmental pollution. In the present study, a simplified and efficient preparation process of PALF, without any pretreatment and subsequent bleaching, was successfully achieved through in-situ inoculation of Bacillus subtilis XW-18 to fresh pineapple leaves. Results showed that B. subtilis XW-18 was rich in the diversified degumming-related enzymes, which could exert an direct retting and degumming action on the fresh pineapple leaves by simultaneously secreting high-activity pectinase, mannanase, and xylanase but low-activity cellulase. Due to the ideal combination of degumming-related enzymes in B. subtilis XW-18, the prepared PALF reached 2.29% of fiber yield and 3.50% of residual gum content, displaying a dispersed fibrous structure and white appearance. Structural characterizations and chemical compositions of PALF further confirmed that B. subtilis XW-18 had an effective action on removal of the non-cellulosic macromolecules such as gummy substances, hemicelluloses, and lignin, thus acquiring a high cellulose content up to 79.36 wt%. Furthermore, the method using in-situ inoculation of B. subtilis XW-18 achieved the prepared PALF with ideal physical and mechanical properties. In summary, B. subtilis XW-18 offered a promising alternative option for the green and efficient preparation of PALF, not only due to its one-step process for PALF preparation, but also due to its ideal combination of the degumming-related enzymes.

Fundamental Properties and Biocompatibility Classification of Extraoral Prosthesis: A Review

This review article discusses on fundamentals of extraoral prosthesis and concerns on the biocompatibility classifications of extraoral prosthesis as medical device. Maxillofacial prosthodontics is a field that seldom being explored. Due to the circumstances, the progression and evolution of research of this area for evidence-based practice are slower comparing to another dental field. Hence, the purpose of this paper is to contribute and provide additional scientific knowledge in related field. Electronic search was done on several databases with keywords ‘maxillofacial prostheses and ‘biocompatibility’. In general, maxillofacial prosthesis can be divided into extraoral prosthesis, intraoral prosthesis, or combination of both depending on the location and function. Ideal properties can be divided into ideal processing characteristics, ideal biologic properties, and ideal physical and mechanical properties of processed extraoral prosthesis materials. Extraoral prosthesis can be classify as Class I or Class II depending on the retentive system according to FDA, and USP Class I and Class III depending on the underlying tissue.

A hyaluronic acid/silk fibroin/poly-dopamine-coated biomimetic hydrogel scaffold with incorporated neurotrophin-3 for spinal cord injury repair

Bio-factor stimulation is essential for axonal regeneration in the central nervous system. Thus, persistent and efficient factor delivery in the local microenvironment is an ideal strategy for spinal cord injury repair. We developed a biomimetic hydrogel scaffold to load biofactors in situ and release them in a controlled way as a promising therapeutic modality. Hyaluronic acid and silk fibroin were cross-linked as the basement of the scaffolds, and poly-dopamine coating was used to further increase the loading of factors and endow the hydrogel scaffolds with ideal physical and chemical properties and proper biocompatibility. Notably, neurotrophin-3 release from the hydrogel scaffolds was prolonged to 28 days. A spinal cord injury model was constructed for hydrogel scaffold transplantation. After eight weeks, significant NF200-positive nerve fibers were observed extending across the glial scar to the center of the injured area. Due to the release of neurotrophin-3, spinal cord regeneration was enhanced, and the cavity area of the injury graft site and inflammation associated with CD68 positive cells were reduced, which led to a significant improvement in hind limb motor function. The results show that the hyaluronic acid/silk fibroin/poly-dopamine-coated biomimetic hydrogel scaffold achieved locally slow release of neurotrophin-3, thus facilitating the regeneration of injured spinal cord. Statement of significanceHydrogels have received great attention in spinal cord regeneration. Current research has focused on more efficient and controlled release of bio-factors. Here, we adopted a mussel-inspired strategy to functionalize the hyaluronic acid/silk fibroin hydrogel scaffold to increase the load of neurotrophin-3 and extend the release time. The hydrogel scaffolds have ideal physiochemical properties, proper release rate, and biocompatibility. Owing to the continuous neurotrophin-3 release from implanted scaffolds, cavity formation is reduced, inflammation alleviated, and spinal cord regeneration enhanced, indicating great potential for bio-factor delivery in soft tissue regeneration applications.

Pyrolyzed Silk Carbon Fabric-Enabled Wearable Functional Actuators With Heating and Sound-Emitting Capabilities

Textile-based wearable electronics are widely favored by researchers due to their superior comfort. However, there are few studies on textile-based flexible actuators with multiple uses. In this article, a highly flexible actuator with heating and sound-emitting capabilities enabled by pyrolyzed silk carbon fabrics is developed. The functionalized fabrics with ideal physical properties are prepared by a high-temperature reduction method, which is simple and efficient. Its electrothermal and photothermal effects endow the device with heating function. The steady-state temperature can reach 188 °C and 280 °C under 0.80-W/cm2 electricity power density and 1.46-W/cm2 laser power density with high stability, respectively. By taking advantage of thermoacoustic effect, it can also produce intuitive sound messages. Test results show that acoustic properties are in good agreement with theoretical model. The output sound pressure level can be stabilized at about 55 dB in the range of 8–20 kHz under 101-mW power. The actuator carries great potentials in wearable thermal and acoustic applications.

Fabrication of Monolithic Para-Aramid Nanofibers/Cellulose Acetate Composite Aerogels with Homogeneous and Durable Cross-Linked Nanostructures for Filtration, Adsorption, and Drug Delivery

Aerogels with porous nanostructures and extremely low densities have drawn a lot of interest recently due to their huge potential applications, but it remains a great challenge to construct tough aerogels with controllable structures. Herein, monolithic composite aerogels consisting of para-aramid nanofibers (ANFs) and cellulose acetate (CA) were successfully fabricated through the “sol–gel-aerogel” process and supercritical fluid drying. The possible presence of complex and strong hydrogen bonds between ANFs and CA was verified by attenuated total reflectance-Fourier transform infrared (ATR-FTIR). To provide a thorough understanding of ANFs/CA composite aerogels, we carefully analyzed their gelation process, macromorphology, micromorphology, porosity, mechanical property, and adsorption capacity. The results show that CA plays a key role in the structural enhancement, porous morphology adjustment, and additional functionalities of the ANFs/CA composite aerogels. ACA-2 exhibited balanced performance across all samples, which has a specific surface area of 315 m2/g, an average pore diameter of 8.53 nm, a pore volume of 0.671 m3/g, a bulk density of 0.0269 g/cm3, a porosity of 98.03%, and a compressive modulus of 1.208 MPa. This work will contribute to the design and production of polymer-based fibrous aerogels with ideal chemical and physical properties. ANFs/CA composite aerogels may have considerable application potential in the fields of filtration, adsorption, and drug delivery.

Development and characterization of chitosan/bacterial cellulose/pullulan bilayer film with sustained release curcumin

A natural biopolymer bilayer film based on chitosan and bacterial cellulose with a protective layer of pullulan was developed by a two-step solution casting method. Curcumin was incorporated as an active antioxidant and antibacterial agent into the inner layer. The films with different curcumin concentrations were systematically characterized. Fourier transform infrared spectroscopy and X-ray diffraction analyses showed high compatibility between curcumin and the polysaccharide matrix through intermolecular interactions, which was verified by enhanced mechanical and barrier properties. The curcumin incorporation improved the thermal stability by >35.4 %, along with lower visible and ultraviolet light transmittance (< 8.6 %) and water solubility (< 25.1 %). The film had both antibacterial and antioxidant properties, and the sustained release of curcumin was largest (> 58.8 %) in the fatty food simulant lasting for over 155 h. The results suggested that the film containing 0.2 % curcumin had ideal physical and functional properties, suggesting its potential as a novel packaging material for the preservation of high-fat food.

Systematic error in the internal friction measurement of coatings for gravitational wave detectors

Low internal friction coatings are key components of advanced technologies such as optical atomic clocks and high-finesse optical cavity and often lie at the forefront of the most advanced experiments in Physics. Notably, increasing the sensitivity of gravitational-wave detectors depends in a very large part on developing new coatings, which entails developing more suitable methods and models to investigate their loss angle. In fact, the most sensitive region of the detection band in such detectors is limited by the coating thermal noise, which is related to the loss angle of the coating. Until now, models which describe only ideal physical properties have been adopted, wondering about the use of one or more loss angles to describe the mechanical properties of coatings. Here we show the presence of a systematic error ascribed to inhomogeneity of the sample at its edges in measuring the coating loss angle. We present a model for disk-shaped resonators, largely used in loss angle measurements, and we compare the theory with measurements showing how this systematic error impacts on the accuracy with which the loss model parameters are known.

Molecularly Precise, Bright, Photostable, and Biocompatible Cyanine Nanodots as Alternatives to Quantum Dots for Biomedical Applications

Fluorescent imaging with fluorophores has become a powerful way to explore complex biological systems and visualize nanoparticles for drug delivery. However, it is challenging to develop fluorophores with ideal physical and optical properties. We report a method to synthesize cyanine nanodots with a single-molecule structure, well-defined particle size, customizable fluorescent spectrum, and bright and stable fluorescence. These cyanine nanodots are acquired by the divergent synthesis of cyanine-dye-cored polylysine (PLL) dendrimers. We demonstrated the feasibility of the method by synthesizing cyanine 3 (Cy3), cyanine 5 (Cy5), or cyanine 7 (Cy7) cored single-molecule nanodots up to eight generations with a size of around 11 nm. We show that these cyanine nanodots are capable of multiple biomedical applications, including multicolor cellular tracing and cancer imaging. These cyanine nanodots possess many merits of organic dots and quantum dots that are promising for future application.

Molecularly Precise, Bright, Photostable, and Biocompatible Cyanine Nanodots as Alternatives to Quantum Dots for Biomedical Applications.

Fluorescent imaging with fluorophores has become a powerful way to explore complex biological systems and visualize nanoparticles for drug delivery. However, it is challenging to develop fluorophores with ideal physical and optical properties. We report a method to synthesize cyanine nanodots with a single-molecule structure, well-defined particle size, customizable fluorescent spectrum, and bright and stable fluorescence. These cyanine nanodots are acquired by the divergent synthesis of cyanine-dye-cored polylysine (PLL) dendrimers. We demonstrated the feasibility of the method by synthesizing cyanine 3 (Cy3), cyanine 5 (Cy5), or cyanine 7 (Cy7) cored single-molecule nanodots up to eight generations with a size of around 11 nm. We show that these cyanine nanodots are capable of multiple biomedical applications, including multicolor cellular tracing and cancer imaging. These cyanine nanodots possess many merits of organic dots and quantum dots that are promising for future application.

Preparation of superabsorbent lignin-based composite inhibitor and research on its prevention and control characteristics of coal spontaneous combustion

ABSTRACT With the potential safety hazard of coal spontaneous combustion becomes more and more serious, in order to solve the problems of low water absorption rate and high cost of hydrogel inhibitor, in this study, a superabsorbent lignin-based composite inhibitor (SAP + SLS + Ben) was prepared. The water absorption/retention rate, micromorphology, inhibition capacity, air-leakage blocking efficiency and fire-extinguishing performance of SAP + SLS + Ben were studied. Results have revealed that: SAP + SLS + Ben had excellent water absorption/retention capacity; SEM images revealed that sodium lignosulfonate (SLS) and bentonite (Ben) provided the structural basis for the high water absorption/retention of SAP + SLS + Ben; Compared with SAP, SAP + SLS + Ben could effectively inhibit the oxidation of reactive functional groups in coal, and the amount of CO released from coal treated with SAP + SLS + Ben was significantly reduced at high temperature; The air-leakage blocking and fire-extinguishing experiments showed that SAP + SLS + Ben had good filling and blocking performance, and could effectively reduce the temperature of coal spontaneous combustion and prevent the re-ignition of coal. Hence, SAP + SLS + Ben had ideal physical and chemical inhibition properties, which could effectively prevent coal spontaneous combustion in goaf.

Formulation and Evaluation of Topical Formula Gel for Dermatitis and Inflammations

Skin allergy is a widespread skin problem at the level of different ages, and it occurs when an irritant comes into contact with the skin, and immune system believes it is under attack, so it overreacts and sends antibodies to help fight invaders. Oral corticosteroids are used to treat the symptoms caused by all kinds of allergic reactions. Long-term use may cause many side effects, such as white water on the eyes, brittleness, weak bones, and stomach ulcers and an increase in blood sugar (glucose) and growth retardation for children. Oral corticosteroids may also worsen high blood pressure. This study has the advantage of designing and testing new topical formulas with standard kinetics and efficacy properties by combining tocopherol with glycolate in addition to antihistamines (phenylephrine hydrochloride and diphenhydramine) to form a Noder formula for the treatment of hypersensitivity. The current study was formulated to manufacture the Noder formula which was submitted to extensive investigations and analyzes by four important models. The results showed that the Noder formula has the ideal physical properties and the absorption is higher than the commercial formula and it has stability for a period of 24 months. The therapeutic efficiency in reducing the degree of redness and sensitivity was 60% compared to 56% in the commercial formula, as well as the clinical safety parameters are better from its comparison of general results, there is a significant increase in absorptivity, efficacy, safety, and consistency of the formula Noder compared to the commercial formula.

Formulation, Characterization and Evaluation of the Topical Nano-formula Gel to Treat Acne Vulgaris

Acne and its harmful effects are considered reasons for the deterioration of the health, social, professional and psychological status of many people, especially in the age of sexual maturity and may lead to chronic skin abnormalities. The treatments used orally and parenterally cause hormonal disorders in addition to side effects on the digestive system. Topical treatment is one of the most important ways to treat acne and the skin abnormalities associated with it, which is characterized by lack of absorption through the skin, but modulating the local formula with nanotechnology and adding absorption stimuli increases the effectiveness of topical treatments. This study has advantage of designing and testing a new topical formula with standard kinetic and effective properties with the nano crystallization of spironolactone-ciprofloxacin-clindamycin-ascorbic acid to form the acne free formula to treat acne as no such design has been tested in laboratory studies. The study aims to increase the absorption, efficacy, and stability of topical treatment through the combination of nano crystalline crystals of spironolactone-ofloxacin-clindamycin-ascorbic acid and then test the resulting compound by diagnosing physical-chemical properties and measuring the absorptivity of the formula across the skin as well as measuring response and clinical safety. The study was conducted within three designs, which are laboratory, animal, and clinical. The laboratory study included diagnosing the physical and chemical properties of the formula by means of optical spectroscopy, pH measurement, peroxide, viscosity, and image processor technology in comparison to the traditional formula. The longitudinal and cross-sectional clinical study of the reviewers’ registry included finding anti-inflammatory efficacy and assessing therapeutic safety. The random sample method and the statistical analysis of the results were adopted, the results showed that the acne free formula had the ideal physical properties as in Table 1 and the absorption is higher than the commercial formula and has stability for a period about 36 months. The rate of active substance absorption was 8% compared to 5% in the commercial formula. Also, the clinical safety parameters are better than their comparison. As in Figure 1 From the general results, there is a significant increase in absorptivity, efficacy, safety, and consistency of the formula acne-free compared to the commercial formula

Preparation and characterization of chitosan films incorporating epigallocatechin gallate: Microstructure, physicochemical, and bioactive properties

Novel chitosan films incorporating epigallocatechin gallate (EGCG) were prepared and demonstrated the ideal physical and mechanical properties required of candidate food packaging materials alongside desirable antioxidant and antibacterial activity. Compared with traditional chitosan films, chitosan films incorporated with EGCG were thicker, had higher tensile strength and water solubility, and had lower elongation at break, moisture content, degree of swelling, and water contact angles. Although EGCG-containing films were slightly darker in color than pure chitosan films, they exhibited a greater inhibitory effect on light-induced oxidation with obviously improved UV–vis barrier capability and opacity. Scanning electron microscopy results suggested that EGCG-incorporated samples had a rougher surface structure. This was further confirmed by atomic force microscopy and indicated that the addition of EGCG facilitated the formation of protective barriers through the interaction between the film and food surface. FTIR spectroscopy confirmed that EGCG interacted with chitosan by intermolecular hydrogen bonding and effectively improved the thermal stability of chitosan films. Notably, the incorporation of EGCG significantly enhanced the antioxidant and antibacterial activity of chitosan films. Hence, chitosan films incorporating EGCG have potential applications in the food industry as a novel active packaging material, especially in preventing food oxidation and spoilage in perishable foods.

A Review on the Current State and Future Perspectives of [99mTc]Tc-Housed PSMA-i in Prostate Cancer.

Recently, prostate-specific membrane antigen (PSMA) has gained momentum in tumor nuclear molecular imaging as an excellent target for both the diagnosis and therapy of prostate cancer. Since 2008, after years of preclinical research efforts, a plentitude of radiolabeled compounds mainly based on low molecular weight PSMA inhibitors (PSMA-i) have been described for imaging and theranostic applications, and some of them have been transferred to the clinic. Most of these compounds include radiometals (e.g., 68Ga, 64Cu, 177Lu) for positron emission tomography (PET) imaging or endoradiotherapy. Nowadays, although the development of new PET tracers has caused a significant drop in single-photon emission tomography (SPECT) research programs and the development of new technetium-99m (99mTc) tracers is rare, this radionuclide remains the best atom for SPECT imaging owing to its ideal physical decay properties, convenient availability, and rich and versatile coordination chemistry. Indeed, 99mTc still plays a relevant role in diagnostic nuclear medicine, as the number of clinical examinations based on 99mTc outscores that of PET agents and 99mTc-PSMA SPECT/CT may be a cost-effective alternative for 68Ga-PSMA PET/CT. This review aims to give an overview of the specific features of the developed [99mTc]Tc-tagged PSMA agents with particular attention to [99mTc]Tc-PSMA-i. The chemical and pharmacological properties of the latter will be compared and discussed, highlighting the pros and cons with respect to [68Ga]Ga-PSMA11.

Fabricating Network-Link Acetamiprid-Loading Micelles Based on Dopamine-Functionalized Alginate and Alkyl Polyglucoside To Enhance Folia Deposition and Retention.

The development of an eco-friendly nanopesticide formulation can alleviate the problems of low pesticide utilization and environmental pollution. However, the development of green nanopesticide carriers with ideal physical properties and specific bioavailability is still a challenging task at present. In this study, we propose a novel binary additive pesticide carrier system that is a functional polysaccharide-based polymer/surfactant (Alg-DA/APG) to improve the deposition and retention of pesticide droplets. The self-assembled micelle morphology of Alg-DA/APG and its effect on the apparent viscosity were investigated by transmission electron microscopy (TEM) and a Discovery HR-2 rotational rheometer. Surface tension was carried out to investigate the surface activity and critical micelle concentration (CMC) of Alg-DA/APG. The drop impacting experiments exhibited superior antisplash performance of Alg-DA/APG. Furthermore, a binary additive was used as the carrier material and loaded acetamiprid to prepare nanopesticide formulation Ace@Alg-DA/APG. The encapsulation efficiency (EE) and acetamiprid release behavior from Ace@Alg-DA/APG were also studied. Moreover, the dynamic contact angle (DCA) and retention experiment showed that the DCA and wetting radius at 600 s were, respectively, 6.8 ± 2.39° and 4.044 ± 0.0662 mm for the Ace@0.05 wt % Alg-DA/0.05 wt % APG on the banana foliage surface, and its retention rates on foliage surface were up to 74.80% after washing. The novel binary additive as a nanopesticide carrier has the potential to alleviate the problems of low pesticide utilization and environmental pollution in the future.

Effect of mixing temperature in the development of green polypropylene – coal bottom ash composite slab

Coal bottom ash (CBA) is a residue produced from the burning of pulverized coal for electricity generation. The high porosity and low abrasion resistance of CBA hindered its commercialization; thus tonnes of CBA were discharged in landfills and surface impoundments. Considering the adverse social and environmental issues associated with disposal management, it is imperative to optimize the utilization of CBA. About 30% of CBA were homogeneously blended with Polypropylene (PP) to produce a “green” PP-CBA composite slab. The influences of mixing temperatures on the physical, chemical and mechanical properties of the fabricated slabs were examined in the study. FESEM micrographs illustrated a smoother surface with a low density of voids in composite systems mixed at low temperatures (190°C). Moisture content was retained in the PP-CBA matrix and imparted supplementary strength to the composite. The relatively amorphous state of the composite allowed for easier dispersion of molecules under applied stress. From the tests, PP-CBA composite slabs mixed at 190°C exhibited the largest drop impact energy and ideal physical and structural properties.

Quality characterization of tight sandstone reservoirs in the Yanchang Formation of the Honghe oilfield, Ordos Basin, central China

Reservoir quality is one of the important geological factors controlling the development of tight oil in the Honghe oilfield, Ordos Basin, northwestern China. Analyses of core, well logging, mud logging and geophysical data as well as thin sections (casting and fluorescence) were combined with testing methods (such as grain size analysis, constant-rate mercury injection, and scanning electron microscopy) to characterize the micropore–throat development in reservoirs of the eighth member of Yanchang Formation in the oilfield. From the perspective of sedimentation and diagenesis, the mechanisms causing reservoir quality difference were explored and a method for characterizing reservoir quality difference and distribution was proposed. The results show that complex and diverse pore–throat configurations and multi-scale throat development are the microscale manifestations of reservoir quality differences in the member. Three types of pore–throat combinations are recognized, including intergranular pore-wide lamellar throat, intergranular and intragranular pore-wide lamellar throat, and intergranular/clustered micropore-wide lamellar throat. Different diagenesis processes and intensities under the control of sedimentary conditions determine the differential development of the reservoirs. Diagenetic facies are the indicators of reservoir quality. Diagenetic facies with chlorite cementation-moderate dissolution indicates reservoirs with the most ideal physical properties for hydrocarbon accumulation, while that with moderate calcite and kaolinite cementations are usually observed in reservoirs with less ideal physical properties. Reservoirs with the worst physical properties often correlate with diagenetic facies with strong calcite cementation and compaction facies. A multi-level constrained method under the control of sedimentation and diagenetic facies is proposed for characterizing tight reservoir quality difference in the member. The spatial distribution of sedimentary elements is analyzed through sedimentary configurations, the diagenetic facies distribution is constrained by sedimentary elements and the reservoir quality distribution is predicted with constraint of diagenetic facies. It suggests that the high-quality reservoirs in the member occur vertically in the middle of thick channel sandstone, while poor reservoirs occur in the upper or lower parts of the channel sandstone due to intensive compaction and cementation. Laterally, the quality of reservoirs enhances along the channels with a change in shape to lens or strips along the middle and downstream sections.