Formulation, Characterization and Evaluation of the Topical Nano-formula Gel to Treat Acne Vulgaris

Abstract

Acne and its harmful effects are considered reasons for the deterioration of the health, social, professional and psychological status of many people, especially in the age of sexual maturity and may lead to chronic skin abnormalities. The treatments used orally and parenterally cause hormonal disorders in addition to side effects on the digestive system. Topical treatment is one of the most important ways to treat acne and the skin abnormalities associated with it, which is characterized by lack of absorption through the skin, but modulating the local formula with nanotechnology and adding absorption stimuli increases the effectiveness of topical treatments. This study has advantage of designing and testing a new topical formula with standard kinetic and effective properties with the nano crystallization of spironolactone-ciprofloxacin-clindamycin-ascorbic acid to form the acne free formula to treat acne as no such design has been tested in laboratory studies. The study aims to increase the absorption, efficacy, and stability of topical treatment through the combination of nano crystalline crystals of spironolactone-ofloxacin-clindamycin-ascorbic acid and then test the resulting compound by diagnosing physical-chemical properties and measuring the absorptivity of the formula across the skin as well as measuring response and clinical safety. The study was conducted within three designs, which are laboratory, animal, and clinical. The laboratory study included diagnosing the physical and chemical properties of the formula by means of optical spectroscopy, pH measurement, peroxide, viscosity, and image processor technology in comparison to the traditional formula. The longitudinal and cross-sectional clinical study of the reviewers’ registry included finding anti-inflammatory efficacy and assessing therapeutic safety. The random sample method and the statistical analysis of the results were adopted, the results showed that the acne free formula had the ideal physical properties as in Table 1 and the absorption is higher than the commercial formula and has stability for a period about 36 months. The rate of active substance absorption was 8% compared to 5% in the commercial formula. Also, the clinical safety parameters are better than their comparison. As in Figure 1 From the general results, there is a significant increase in absorptivity, efficacy, safety, and consistency of the formula acne-free compared to the commercial formula