This paper focuses on the in-depth exploration and practice of innovation programs for college students in the context of new engineering disciplines, combined with the current development trend of generative AI technology. Through nearly 2 years of practical exploration of college students' imitative innovative thinking, especially in the new undergraduate colleges and universities, college students' innovative thinking cultivation effectiveness has achieved better results. This paper focuses on analyzing the impact of AI technology on the innovation and entrepreneurship projects of college students in new undergraduate colleges under the background of new engineering and the importance of cross-border integration and innovation under the concept of new engineering education, and summarizes and puts forward an inter-disciplinary fusion of imitative innovation of college students' innovation and entrepreneurship teaching ideas in new undergraduate colleges, which focuses on innovation inspiration, project practice, competition-driven, and inter-disciplinary fusion, and aims to improve the students' comprehensive innovation ability and ability to cope with complex problems. ability and the ability to deal with complex problems. It has been proved that this borrowed innovative thinking has significant effect on the cultivation of innovative thinking of college students in new undergraduate colleges and meets the cultivation requirements of local talents in the era of new engineering science.