Teachers in Asian countries confront major problems adjusting to online teaching and establishing a minimum extent of communication with students to support their learning and growth during the COVID-19 pandemic. This study aimed to examine the challenges faced by English as a second language teachers in Asia while implementing e-learning during COVID-19. The study employed a quantitative cross-sectional research technique using a total of 300 ESL teachers from the selected Asian countries, Malaysia, India, Indonesia, Sri Lanka, Thailand, and China, with different demographic backgrounds. The data was analyzed using a standard multiple regression model. The results showed that the teachers’ ICT competence, the infrastructure, and resources available to the teachers, and the suitability of working environment had a significant positive impact on implementing e-learning during Covid-19. This study suggested that policymakers can use the findings to plan curriculum by considering teachers' ICT skills as well as access to infrastructure and online resources.