The world has been in combat with COVID-19 since December 2019. The United States has been paralyzed, with the highest number of cases and more deaths than any other country. However, the disease has devastated almost every nation across the globe, from the Far East to Europe, Latin America, Russia, and India. In this article, we cover emerging blood gas monitoring devices and techniques to create the sensors and IC structures to transform bulky benchtop instruments into miniaturized, next-generation bio-medical devices. We also explore currently available technologies, with a short glance back to the evolution of blood gas sensing systems.