With the intention to explore bile salts applications as drug delivery vehicles, the mixed interfacial as well as micellar behavior of the sodium salt of ibuprofen (NaIbuF) and bile salts mixtures in aqueous/electrolyte solutions has been evaluated by tensiometric method at 298.15 K. Bile salts (sodium cholate (NaC) and sodium deoxycholate (NaDC)) used in the present study are anionic in nature and form small micelles. Various theoretical models such as Clint, Rubingh, and Rosen were utilized to acquire information concerning the nature of interaction among the components in the solution as well as at the interface. Because of the presence of inorganic salt (100 mmol·kg–1 NaCl) a decrease in the surface charge of the micelles takes place and ensuing micellization occurs at poorer concentration. The value of the micellar mole fraction (X1m) is found to be greater for NaIbuF + NaDC mixtures in comparison to NaIbuF + NaC mixtures, signifying that participation of NaDC is greater in mixed micelles as compared...