Background: The present study was conducted to describe the first experience with hysterosalpingo-foam sonography (HyFoSy) as a routine office procedure to check for tubal patency in infertility clinic of Dubai Hospital. Materials and Methods: A retrospective, observational study was conducted. Hundred patients with subfertility and low risk of tubal pathology were examined. A non-toxic HyFoSy foam containing hydroxymethyl cellulose and glycerol was applied through the cervical applicator for contrast sonography. Tubal patency was determined by transvaginal ultrasound by demonstrating echogenic dispersion of foam in Fallopian tubes and or in the peritoneal cavity. Only in cases where patency could not be demonstrated, hystosalpingogram/laparoscopy was performed as a control. Inclusion Criteria: All patients who underwent HyFoSy in infertility clinic in Dubai hospital were included in the study. Exclusion Criteria: Any patient with active tubal disease such as pelvic inflammatory disease, endometriosis and previous ectopic pregnancy were excluded from the study. Results: One hundred patients were observed in the study. HyFoSy was successful in 97 patients (97%) and was failed in three patients (3%). Bilateral patency was seen in 72 patients (74%), bilateral blockage was seen in six cases (6.1%), delayed spill was seen in five patients (5%) and hydrosalpinx was found in 1 patient (1%). Antibiotics were given to 97 patients (100%). Out of the 97 patients who successfully underwent HyFoSy, 17 conceived within 6 months after the procedure. Conclusion: HyFoSy is a successful procedure to demonstrate tubal patency as the first step office procedure.