As the secondary fault of the Niushoushan-Luoshan Fault Zone, the Liumugao Fault records the northeastward expansion of the Tibetan Plateau. Based on WorldDEM data, 11 rivers (R1-R11) that flow across the Liumugao Fault and their drainage basins were extracted using ArcGIS technology and a MATLAB script. The longitudinal profiles, Hack profiles, and stream length-gradient (SL) indexes of these rivers, as well as the hypsometric integral (HI) of their drainage basins, were extracted and calculated and combined with field observations to quantitatively analyze the activity of Liumugao Fault. The results show that: (1) the longitudinal profiles of the 11 rivers are steep, the Hack profiles of most rivers drop sharply at the main fault, and the average HI value of the drainage basins is ∼0.4. These phenomena indicate that the current activity of the fault is strong. (2) The average HI values of the drainage basins in the northern, middle, and southern segments of Liumugao Fault are 0.32, 0.37 and 0.45, respectively. Accordingly, the average normalized stream-gradient (SL/K) values of the three segments are 3.72, 4.64 and 7.16, respectively. These data show that the activity of the Liumugao Fault gradually increases from north to south.