Environmental contamination of heavy metals is now becoming increasingly a concern and a significant problem due to its harmful effects worldwide. The plant-meditated approach is encouraging to eliminate toxins avoiding side effects from polluted wastewater. For the development of appropriate plant species for the mechanisms of heavy metal absorption, transport, detoxification, identification, and signaling pathways would be important facts. Transporter genes like ATP-phosphoribosyl transferase (ATP-PRT), Yellow Stripe-like (YSL), NAS (nicotinamide synthase), SAMS (S-adenosyl-methionine synthetase), FER (ferritin Fe (III) binding), HMA (heavy metal ATPase), IREG (iron-regulated transporter), and proteins like cation diffusion facilitators (CDF), ZRT, IRT-like protein (ZIP), and natural resistance-associated macrophage protein (NRAMP) are active in heavy metal accumulation, translocalisation, sequestration, and resistance. Besides, chelating agents and metabolites can be used either to increase heavy metal bioavailability, which facilitates heavy metal accumulation in plants and further promote plant growth and fitness. This review paper addresses key roles and potential transporter genes and proteins for the remediation of heavy metals from hyperaccumulator plants. This review specifically focuses on the efficacy of transporter genes and proteins in hyperaccumulator plants in metal restoration, discussing the use of these plants for wastewater treatment processes. • Discusses the efficiency of hyperaccumulator plant for removal of metals. • Summarizes transporter gene and proteins in heavy metal uptake and tolerance. • Proposes improved prospects for wastewater treatment.