To improve the stimulation effect of sandstone reservoirs, NSDR is used to reduce the adsorption damage of hydroxypropyl guar gum fracturing fluid to sandstone the throats of sandstone. The adsorption capacity of guar gum in porous sandstone media is measured by an ultraviolet spectrophotometer. The effect of the nanometer silica desorption reagent (NSDR) on reducing adsorption damage was evaluated by displacement experiment combined with nuclear magnetic resonance, and the effects of temperature and residence time on the properties of NSDR were studied. The mechanism of reducing adsorption damage of NSDR was verified by X-ray electron spectroscopy and scanning electron microscope. The results show that NSDR can destroy the adsorption force between guar gum and rock and occupy the adsorption site on the rock surface, thus reducing the adsorption retention of HPG in sandstone porous media, reducing permeability damage, and improving pore throat structure. The temperature has little effect on the adsorbing properties of NSDR. The effect of NSDR is better after the residence time exceeds 240 min, and the longer the residence time, the better the effect. The addition of NSDR can effectively reduce the viscosity and surface tension of the gel breaker, and does not affect the rheological properties and gel breaking performance of the fracturing fluid. The field application results show that compared with the adjacent wells, the single well production of the NSDR application well increases obviously, and the cumulative production increases by 2.1 times after 100 days.