This experimental study presents the results of the growth of herbaceous plants of the genus Arum (Arum korolkowii) of a red-book nature. The experiments were carried out by the DWC (deep-sea culture) method in a low-volume hydroponic installation in the conditions of the South clinical and genetic laboratory (South Kazakhstan Medical Academy). The paper also presents analyses and analysis of various substrates for conducting experiments in closed and open ground, growing and developing plants for industrial and private purposes, and also examines the patterns of substrate selection depending on the goals of the experiment. Solutions to the noted problems are proposed. Conclusions about the optimal conditions of cultivation of the studied crops are formulated. A review of the literature data on the medicinal plant Arum endemic to the territory of Kazakhstan and of great interest for phytochemical study. The main reasons for the disappearance of many types of these plants in recent years are the negative interference of wild animals and humans, and the deterioration of environmental conditions. When discussing the medicinal properties of plants of the Araceae family, it is doubly sad, especially their importance cannot be underestimated. Despite the fact that these herbs reduce the signs of a number of pathologies and facilitate their course, medicinal species of Arum in Kazakhstan are in danger of extinction. On October 31, 2006, the Government of the Republic of Kazakhstan entered a list of plants in the Red Book, including the plant of the Arum.