The geomorphology of a basin makes it possible for us to understand its hydrological pattern. Accordingly, satellite-based remote sensing and geo-information technologies have proven to be effective tools in the morphology analysis at the basin level. Consequently, this present study carried out a morphological analysis of the Sinú river basin, analyzing its geometric characteristics, drainage networks, and relief to develop integrated water resource management. The analyzed zone comprises an area of 13,971.7 km2 with three sub-basins, the upper, the middle, and the lower Sinú sub-basins, where seventeen morphometric parameters were evaluated using remote sensing (RS) and geographical information system (GIS) tools to identify the rainwater harvesting potential index. The Sinú basin has a dendritic drainage pattern, and the results of the drainage network parameters make it possible for us to infer that the middle and lower Sinú areas are the ones mainly affected by floods. The basin geometry parameters indicate an elongated shape, implying a lesser probability of uniform and homogeneous rainfall. Additionally, the hypsometric curve shape indicates that active fluvial and alluvial sedimentary processes are present, allowing us to conclude that much of the material has been eroded and deposited in the basin’s lower zones as it could be confirmed with the geological information available. The obtained results and GIS tools confirm the basin’s geological heterogeneity. Furthermore, they were used to delimit the potential water harvesting zones following the rainwater harvesting potential index (RWHPI) methodology. The research demonstrates that drainage morphometry has a substantial impact on understanding landform processes, soil characteristics, and erosional characteristics. Additionally, the results help us understand the relationship between hydrological variables and geomorphological parameters as guidance and/or decision-making instruments for the competent authorities to establish actions for the sustainable development of the basin, flood control, water supply planning, water budgeting, and disaster mitigation within the Sinú river basin.