The terahertz absorption of water is mainly caused by internal hydrogen bonds, and many proteins can maintain their biological activity only in liquid environment. This paper mainly studies the effect of active protein buffer solution on water-hydrogen bond to minimize the effect of water in buffer solution on terahertz. In order to improve the accuracy of the experimental results, a metamaterial absorber was designed to study its terahertz absorption characteristics by injecting protein buffer solution into the metamaterial-absorber. The effects of anions and cations of different protein buffer solutions on hydrogen bonds in water molecules were analyzed. The results show that the effect on the hydrogen bond of water molecules is mainly affected by the viscosity coefficient. The hydrogen bond association of water molecules can be broken when the viscosity coefficient is less than 0, and can be promoted when the viscosity coefficient is greater than 0. Therefore, the protein buffer solution can be composed of anions and cations whose viscosity coefficients are all less than 0.