A computational mechanism has been formulated to scientifically analyze the phenomenon of combined convection in the occurrence of magnetohydrodynamic flow behavior of Casson nanofluid. This study emphasizes the trajectory of the nanofluid along a stretching sheet with nonlinear permeability, while considering additional physical effects such as reversible chemical reaction, thermal radiation, energy source/sink, suction and viscous dissipation. In this study, we have additionally integrated the nanofluid paradigm proposed by Buongiorno, which encompasses the repercussion of thermophoresis along with Brownian motion. The utilization of appropriate similarity renovations serves the purpose of recasting the dominant multivariate differential equations to a collection of nonlinear differential equations in single variable. The Runge–Kutta shooting mechanism is implemented for the intention of numerically determining the unknown boundary conditions. The solution to the dominant equations was obtained by employing the fourth-order Runge–Kutta technique and to ensure the dependability of the outcomes, the bvp4c method was employed. The graphical and tabulated observations are presented herein to facilitate a comprehensive analysis of the underlying physical characteristics inherent in the problem at hand. The utilization of the Casson parameter has been found to be advantageous in the reduction of shear stress rate, along with the enhancement of mass and energy transfer rates. Additionally, the application of suction has been observed to be beneficial in the enhancement of Sherwood number and energy transfer rate. Within the scope of the context of the esterification process, the purpose of this proposal is to evaluate the impact that numerous arithmetical values exert on the temperature field, the velocity profile and the volumetric concentration. An in-depth graphical analysis that takes into account the relevant physical consequences is used to evaluate the most important factors that relate to the physical quantities that describe the contours of temperature, velocity and concentration. In addition to being accompanied by their respective explanations, the tabular portrayal of the local Sherwood number, shear stress rate along with local Nusselt number all feature in this paper. There is a clear distinction that can be made between irreversible and reversible flows in the evaluation of the local Sherwood number, rate of shear stress and local Nusselt number. This differentiation is brought about by taking into analysis thermophoresis parameter, Brownian motion parameter and suction parameter. The results that were produced from the theoretical simulations have significant repercussions for a variety of fields that are related to energy engineering. The findings derived from the analysis indicate a negative correlation between the Brownian motion parameter and both irreversible and reversible flow in terms of rate of energy transfer and shear stress rate. It is imperative to highlight that reversible flow holds greater significance in comparison to irreversible flow.