Hybrid Fiber Reinforced Polymers (HFRP) have excellent mechanical properties. However, preparation with 3D-printing technology is prone to hydrothermal aging compared to conventional method. Currently, complex hygrothermal aging and degradation mechanisms of 3D-printed HFRP are still unclear. Thus, hygrothermal aging and durability prediction of 3D-printed HFRP with continuous carbon/Kevlar-fiber and short carbon-fiber are studied, which considers four typical stacking sequences. All experimental samples are manufactured by Fused Deposition Modeling (FDM) 3D-printing. The artificial accelerate aging testing is conducted on samples at different times, and then flexural testing is adopted to evaluate the residual mechanical properties and failure modes. The results show that the stacking sequence significantly influences the moisture absorption behaviors, and [OC4O2K4]S absorbed more moisture than [OK4O2C4]S. During the aging process, the flexural properties of the 3D-printed HFRP first decrease rapidly and then keep stable. Among them, [OK4O2C4]S have the fastest degradation but possessed the highest residual strength. OC8O4K8O possess the slowest degradation but have a lower residual strength. The morphologies and micro failure modes/mechanisms are analyzed to explain the significant mechanical degradation. Finally, the Arrhenius relationship is adopted to accurately predict and analyze the degradation evolution process of specimens. This work offers a novel perspective on the hygrothermal aging and durability of 3D-printed HFRP.