Human Uterine Contractility Research Articles

PGH 2, TxA 2 and PGI 2 have potent and differentiated actions on human uterine contractility

The contractile response to three different prostanoids of the isolated human myometrium and the different layers of the utero-tubal junction (UTJ) was studied in vitro . The prostaglandin endoperoxide, PGH 2, stimulated contractility of both the myometrium and the outer and inner muscle layers of the UTJ, whereas the intermediate layer of the UTJ was inhibited. Thromboxane A 2 generated from PGH 2 and a thromboxane synthase preparation caused a stimulation of both the myometrium and all three layers of the UTJ. The stimulatory response to TxA 2 occurred at concentrations as low as 50–70 pg/ml. The sodium salt of PGI 2 was found to relax both the myometrium and all the layers of the UTJ. Intravenous administration of PGI 2 in repeated doses between 2–8 μg induced facial flushing and headache but had little if any effect on in vivo uterine contractility. At least under in vitro conditions, these short-lived prostanoids and/or their metabolites apparently have a specific action on uterine contractility, an action which is manifested at comparatively low concentrations.

Paradoxical effect of flavoxate on human uterine contractility in vivo.

Flavoxate's effect on uterine contractility was investigated in 20 women with histories of primary dysmenorrhea. After 100 mg of the smooth muscle relaxant was infected intravenously, intrauterine pressure was recorded continuously for 1--2 hours. Immediately after the injection, intrauterine pressure and the frequency of contractions increased for 5--15 minutes at all phases of the menstrual cycle. After the activating response, there was a reduction in both the frequency of contractions and uterine tonus below preinjection levels in some patients. The paradoxical effect of flavoxate on uterine motility may be caused by its relaxation of vascular smooth muscle, which results in increased blood flow and, consequently, increased oxygen supply to the myometrium.

The influence of prostaglandin metabolites on the uterine response to PGF 2α. A clinical and pharmacokinetic study

Prostaglandin F 2α (PGF 2α) is rapidly metabolized in the human body following exogenous administration. Three main metabolites have been isolated and identified: 15-keto-PGF 2α, 15-keto-13, 14-dihydro-PGF 2α and 13, 14-dihydro-PGF 2α. One of these metabolites, 13, 14-dihydro-PGF 2α, stimulated human uterine contractility during midpregnancy both following intravenous and intra-amniotic administration. The activity approaches that of the parent compound, PGF 2α. Since the concentration of the metabolites in peripheral serum during continuous intravenous infusion of PGF 2α is only slightly lower than that found for PGF 2α, it is likely that 13, 14-dihydro-PGF 2α is of importance for the stimulatory effect of PGF 2α on human uterine activity in vivo. Intravenous injection of high doses of 15-keto-13, 14-dihydro-PGF 2α (2–4 mg) slightly stimulated uterine contractility but most likely this effect was not due to the compound itself but to the formation of its metabolite, 13, 14-dihydro-PGF 2α.

In vivo effect of amyl nitrite on human pregnant uterine contractility: An objective evaluation

In vivo effect of amyl nitrite on human pregnant uterine contractility: An objective evaluation

An objective evaluation of paracervical block on human uterine contractility

An objective evaluation of paracervical block on human uterine contractility

In vitro and in vivo effects of promethazine hydrochloride on human uterine contractility

Abstract 1. In vitro inhibitory effect of promazine hydrochloride on the myometrium from the uteri of pregnant and nonpregnant patients has been confirmed. 2. In vivo promazine also decreases uterine activity, the changes being in the amplitude and frequency of the contractions. No change in tonus was noted.

In vitro and in vivo effects of Sparine (promazine hydrochloride) on human uterine contractility

1. In vitro inhibitory effect of promazine hydrochloride on the myometrium from the uteri of pregnant and nonpregnant patients has been confirmed.2. In vivo promazine also decreases uterine activity, the changes being in the amplitude and frequency of the contractions. No change in tonus was noted.

Studies on human premature births: II. In vivo effect of smoking and in vitro effect of nicotine on human uterine contractility

1. To the best of our knowledge, for the first time, in 17 gravidas near term in vivo effect of cigarette smoking has been reported objectively on the spontaneous activity of the human uterus. The effect of nicotine, per se, has also been evaluated on human pregnant and nonpregnant myometrial strips.2. In more than half of the gravidas near term a definite increment in uterine activity was noticed during cigarette smoking. However, nicotine in vitro experiments on human myometrial strips did not show any oxytocic effect.3. The significance and the mechanism of action of smoking on uterine contractility have been discussed.

In vitro and in vivo effects of magnesium sulfate on human uterine contractility

In vitro and in vivo effects of magnesium sulfate on human uterine contractility

In vitro and in vivo effects of sparteine sulfate on human uterine contractility—an objective evaluation

In vitro and in vivo effects of sparteine sulfate on human uterine contractility—an objective evaluation

Effect of dihydroergotamine on human uterine contractility: Bruns, Paul D., Snow, Robert H., and Drose, Vera E.: Obst. & Gynec. 1: 188, 1953

Effect of dihydroergotamine on human uterine contractility: Bruns, Paul D., Snow, Robert H., and Drose, Vera E.: Obst. & Gynec. 1: 188, 1953

STUDIES ON THE MOTILITY OF THE HUMAN UTERUS IN VIVO

The present study was begun in January 1937 primarily to determine the nature of the uterine contractions in functional dysmenorrhea. It was soon realized that to evaluate these findings properly a thorough investigation of the fundamental aspects of human uterine contractility was a necessary preliminary. The following material was utilized in the study.