Human Test Subjects Research Articles

Improving the accuracy of infrared measurements of skin temperature

In principle, infrared (IR) imagery of exposed skin and clothing can provide a valuable source of data for thermo-physiological studies. In practice, and despite the fall in the cost of IR cameras, infrared imagery is not universally collected during human subject testing. One reason for this may be the relatively poor accuracy of IR cameras (typically ±2 °C). The repeatability of the measurements taken with a particular IR camera (both spatially and temporally) is much better than its accuracy, i.e., close to the camera's sensitivity. An IR camera's sensitivity (and repeatability) is typically on the order of hundredths of a degree Celsius. Consequently, a reference with known temperature and emissivity placed in the camera's field-of-view when taking measurements can provide two potential benefits: First, measurement error can be reduced by using a calibration procedure. Second, IR imagery taken by different IR cameras during different test episodes can be directly compared.

Comparison of Simulated Workplace Protection Factors Offered by N95 and P100 Filtering Facepiece and Elastomeric Half-Mask Respirators against Particles of 10 to 400 nm.

This study compared the simulated workplace protection factors (SWPFs) between NIOSH-approved N95 respirators and P100 respirators, including two models of filtering facepiece respirator (FFR) and two models of elastomeric half-mask respirator (EHR), against sodium chloride particles (NaCl) in a range of 10 to 400 nm.Twenty-five human test subjects performed modified OSHA fit test exercises in a controlled laboratory environment with the N95 respirators (two FFR models and two EHR models) and the P100 respirators (two FFRs and two EHRs). Two Scanning Mobility Particle Sizers (SMPS) were used to measure aerosol concentrations (in the 10–400 nm size range) inside (Cin) and outside (Cout) of the respirator, simultaneously. SWPF was calculated as the ratio of Cout to Cin. The SWPF values obtained from the N95 respirators were then compared to those of the P100 respirators.SWPFs were found to be significantly different (P<0.05) between N95 and P100 class respirators. The 10th, 25th, 50th, 75th and 90th percentiles of the SWPFs for the N95 respirators were much lower than those for the P100 models. The N95 respirators had 5th percentiles of the SWPFs > 10. In contrast, the P100 class was able to generate 5th percentiles SWPFs > 100. No significant difference was found in the SWPFs when tested against nano-size (10 to 100 nm) and large-size (100 to 400 nm) particles.Overall, the findings suggest that the two FFRs and two EHRs with P100 class filters provide better performance than those with N95 filters against particles from 10 to 400 nm, supporting current OSHA and NIOSH recommendations.

Ocular Blood Flow Response to Applied Force: In Vivo Tests Toward Noninvasive Intracranial Pressure Monitoring1

Ocular Blood Flow Response to Applied Force: In Vivo Tests Toward Noninvasive Intracranial Pressure Monitoring1

Lower Leg Injury Reference Values and Risk Curves from Survival Analysis for Male and Female Dummies: Meta-analysis of Postmortem Human Subject Tests

Objective: Derive lower leg injury risk functions using survival analysis and determine injury reference values (IRV) applicable to human mid-size male and small-size female anthropometries by conducting a meta-analysis of experimental data from different studies under axial impact loading to the foot–ankle–leg complex.Methods: Specimen-specific dynamic peak force, age, total body mass, and injury data were obtained from tests conducted by applying the external load to the dorsal surface of the foot of postmortem human subject (PMHS) foot–ankle–leg preparations. Calcaneus and/or tibia injuries, alone or in combination and with/without involvement of adjacent articular complexes, were included in the injury group. Injury and noninjury tests were included. Maximum axial loads recorded by a load cell attached to the proximal end of the preparation were used. Data were analyzed by treating force as the primary variable. Age was considered as the covariate. Data were censored based on the number of tests conducted on each specimen and whether it remained intact or sustained injury; that is, right, left, and interval censoring. The best fits from different distributions were based on the Akaike information criterion; mean and plus and minus 95% confidence intervals were obtained; and normalized confidence interval sizes (quality indices) were determined at 5, 10, 25, and 50% risk levels. The normalization was based on the mean curve. Using human-equivalent age as 45 years, data were normalized and risk curves were developed for the 50th and 5th percentile human size of the dummies.Results: Out of the available 114 tests (76 fracture and 38 no injury) from 5 groups of experiments, survival analysis was carried out using 3 groups consisting of 62 tests (35 fracture and 27 no injury). Peak forces associated with 4 specific risk levels at 25, 45, and 65 years of age are given along with probability curves (mean and plus and minus 95% confidence intervals) for PMHS and normalized data applicable to male and female dummies. Quality indices increased (less tightness-of-fit) with decreasing age and risk level for all age groups and these data are given for all chosen risk levels.Conclusions: These PMHS-based probability distributions at different ages using information from different groups of researchers constituting the largest body of data can be used as human tolerances to lower leg injury from axial loading. Decreasing quality indices (increasing index value) at lower probabilities suggest the need for additional tests. The anthropometry-specific mid-size male and small-size female mean human risk curves along with plus and minus 95% confidence intervals from survival analysis and associated IRV data can be used as a first step in studies aimed at advancing occupant safety in automotive and other environments.

Improving Longevity of Gelatin Ultrasound Trainers

Medical schools are increasingly integrating ultrasound training into their curricula as ultrasound utility expands in medical practice. Homemade ballistic gelatin ultrasound trainers have been developed as teaching tools that bypass the logistical complications of human test subjects and expense of commercial phantoms. This study explored methods to impede mold growth and extend the longevity of homemade trainers through chemical additives and physical barriers. Thirty‐five 500 mL forms with a base formula of gelatin (10% by weight) and Metamucil (2.5% by weight) in water were created in 750 mL Tupperware containers. Five had no additives or surface coverings; 8 contained the preservative Carolina's Perfect Solution; 7 contained the antiseptic surgical scrub Betasept; and 5 each had the exposed surface covered in plastic wrap, Duoderm bandages, or Tegaderm bandages. All containers were lidded, refrigerated at 4⁰ C and checked weekly for number and diameter of growing mold colonies. By week 6, all gelatin forms except those treated with Betasept or covered with Duoderm bandages had developed mold, with colony number ranging from 1‐4 and diameters from 1‐16 mm. While 2 of 5 Duoderm trials developed mold in week 10, all Betasept trials remained mold free through 25 weeks. Adding 1% Betasept by weight during gelatin trainer creation is recommended as a low cost, low hazard method for preventing mold growth.

Simulation of Occupant Response in Space Capsule Landing Configurations With Suit Hardware

The purpose of this study was to compare the response of the total human model for safety (THUMS) human body finite element model (FEM) to experimental postmortem human subject (PMHS) test results and evaluate possible injuries caused by suit ring elements. Experimental testing evaluated the PMHS response in frontal, rear, side, falling, and spinal impacts. The THUMS was seated in a rigid seat that mirrored the sled buck used in the experimental testing. The model was then fitted with experimental combinations of neck, shoulder, humerus and thigh rings with a five-point restraint system. Experimental seat acceleration data was used as the input for the simulations. The simulation results were analyzed and compared to PMHS measurements to evaluate the response of the THUMS in these loading conditions. The metrics selected to compare the THUMS simulation to PMHS tests were the chest acceleration, seat acceleration and belt forces with additional metrics implemented in THUMS. The chest acceleration of the simulations and the experimental data was closely matched except in the Z-axis (superior/inferior) loading scenarios based on signal analysis. The belt force data of the model better correlated to the experimental results in loading scenarios where the THUMS interacted primarily with the restraint system compared to load cases where the primary interaction was between the seat and the occupant (rear, spinal and lateral impacts). The simulation output demonstrated low injury metric values for the occupant in these loading conditions. In the experimental testing, rib fractures were recorded for the frontal and left lateral impact scenarios. Fractures were not seen in the simulations, most likely due to variations between the simulation and the PMHS initial configuration. The placement of the rings on the THUMS was optimal with symmetric placement about the centerline of the model. The experimental placement of the rings had more experimental variation. Even with this discrepancy, the THUMS can still be considered a valuable predictive tool for occupant injury because it can compare results across many simulations. The THUMS also has the ability to assess a wider variety of other injury information, compared to anthropomorphic test devices (ATDs), that can be used to compare simulation results.

Finite Element Study of Human Pelvis Model in Side Impact for Chinese Adult Occupants

Objective: The occupant's pelvis is very vulnerable to side collision in road accidents. Finite element (FE) studies on pelvic injury help to design occupant protection devices to improve vehicle safety. This study was aimed to develop a highly biofidelic pelvis model of Chinese adults and assess its sensitivity to variations in pelvis cortical bone thickness, bone material properties, and loading conditions.Methods: In this study, 4 different FE models of the pelvis were developed from the computed tomography (CT) data of a volunteer representing the 50th percentile Chinese male. Two of them were meshed using entirely hexahedral elements with variable and constant cortical thickness distribution (the V-Hex and C-Hex models), and the others were modeled with hexahedral elements for cancellous bone and variable or constant thickness shell elements for cortical bone (the V-HS and C-HS models). In model developments, the semi-automatic multiblock meshing approach was employed to maintain the pelvis geometric curvature and generate a high-quality hexahedral mesh. Then, several simulations with postmortem human subjects (PMHS) tests were performed to obtain the most accurate model in predicting pelvic injury. Based on the most accurate model, sensitivity studies were conducted to analyze the effects of the cortex thickness, Young's modulus of the cortical and cancellous bone, impactor velocity, and impactor with or without padding on the biomechanical responses and injuries of pelvis.Results: The results indicate that the models with variable cortical bone thickness can give more accurate predictions than those with constant cortical thickness. Both the V-Hex and V-HS models are favorable for simulating pelvic response and injury, but the simulation results of the V-Hex model agree with the tests better. The sensitivity study shows that pelvic response is more sensitive to alterations in the Young's modulus of cortical bone than cancellous bone. Compared to failure displacement, peak force is more sensitive to the cortical bone thickness. However, displacement is more sensitive to the Young's modulus of cancellous bone than peak force. The padding attached on the impactor plays a significant role in absorbing the impact energy and alleviating pelvic injury.Conclusions: The all-hex meshing method with variable cortical bone thickness has the highest accuracy but is time-consuming. The cortical bone plays a determining role in resisting pelvic fracture. Peak impact force appears to be a reasonable injury predictor for pelvic injury assessment. Some appropriate energy absorbers installed in the car door can significantly reduce pelvic injury and will be beneficial for occupant protection.

Correlation of Respirator Fit Measured on Human Subjects and a Static Advanced Headform

This study assessed the correlation of N95 filtering facepiece respirator (FFR) fit between a Static Advanced Headform (StAH) and 10 human test subjects. Quantitative fit evaluations were performed on test subjects who made three visits to the laboratory. On each visit, one fit evaluation was performed on eight different FFRs of various model/size variations. Additionally, subject breathing patterns were recorded. Each fit evaluation comprised three two-minute exercises: “Normal Breathing,” “Deep Breathing,” and again “Normal Breathing.” The overall test fit factors (FF) for human tests were recorded. The same respirator samples were later mounted on the StAH and the overall test manikin fit factors (MFF) were assessed utilizing the recorded human breathing patterns. Linear regression was performed on the mean log10-transformed FF and MFF values to assess the relationship between the values obtained from humans and the StAH.This is the first study to report a positive correlation of respirator fit between a headform and test subjects. The linear regression by respirator resulted in R2 = 0.95, indicating a strong linear correlation between FF and MFF. For all respirators the geometric mean (GM) FF values were consistently higher than those of the GM MFF. For 50% of respirators, GM FF and GM MFF values were significantly different between humans and the StAH. For data grouped by subject/respirator combinations, the linear regression resulted in R2 = 0.49. A weaker correlation (R2 = 0.11) was found using only data paired by subject/respirator combination where both the test subject and StAH had passed a real-time leak check before performing the fit evaluation. For six respirators, the difference in passing rates between the StAH and humans was < 20%, while two respirators showed a difference of 29% and 43%. For data by test subject, GM FF and GM MFF values were significantly different for 40% of the subjects. Overall, the advanced headform system has potential for assessing fit for some N95 FFR model/sizes.

J0240106 筋制御法を用いた低速後突時の頭頚部挙動予測

Whiplash injury with neck pain is the most frequent injury due to low-speed rear-end impacts in Japan, but the injury mechanism is still unknown. Some researchers proposed their hypotheses for the injury mechanisms from their studies based on Post Mortem Human Subject (PMHS) tests, volunteer tests, and computer simulations using human body finite element (FE) models. Although the human body FE models are useful to evaluate the hypotheses, the active muscles should be modeled and integrated with a human body FE model to investigate the injury mechanism in real-world accidents. In this study, we developed a human body FE model with active muscles and a muscle controller for posture maintenance. The model was used under a rear impact condition with 8 km/h, and reproduced the same head-neck responses as the volunteer test data. The human body FE model with the muscle controller have the potential to investigate damages due to elongations of neck muscles during low-speed rear-end impacts.

Biomechanical response and injury effects on occupant's thorax-abdomen under seat belt loading

In this study, a Finite Element (FE) model of adult occupant was developed to investigate the thoracic and abdominal injuries caused by seat belt wearing. A model geometry was created from the CT data of a volunteer representing the 50th percentile Chinese male. The anatomical structures and physical characteristics were modelled the same as those in the real human body. Especially the thorax and abdomen model included details of the ribcage, thoracic and lumbar spine, pelvis, internal organs, skin, muscles, ligaments, main arteries and veins, and other soft tissues. Through simulations against Post–Mortem Human Subjects (PMHS) tests of seat belt loading, good agreements were achieved between them in terms of the force and deflection responses and injury distributions. Moreover, the effective analyses of seat belt design parameters indicated that the belt fabric tape stiffness, pre–tension force and upper slipping position played an important role on the thoracic and abdominal injuries.

BIOMECHANICAL RESPONSE AND INJURY OF OCCUPANT'S PELVIS IN SIDE IMPACTS: EFFECTS OF THE FEMORAL HEAD AND LOADING CONDITIONS

The occupant's pelvis is most susceptible to injuries in side collision accidents. To further investigate the pelvis biomechanical responses and injury mechanisms in side impacts, a biofidelic pelvis finite element (FE) model was created. In contrast to previous studies, the model was based directly on the CT data of a volunteer representing the 50th percentile Chinese male. Both cortical and cancellous bone were modeled with hexahedral elements. Through model validations against Post Mortem Human Subjects (PMHS) tests, the pelvis responses and injuries under side impacts were analyzed. Meanwhile, additional simulations were carried out utilizing the validated model to study the effects of the femoral head, impactor pad and impactor velocity on pelvic injuries. The results indicated that the most frequent injury type of the pelvis is pubic rami fracture, followed by fractures of the femoral head, greater trochanter and acetabulum. In validation against the test of Guillemot et al., the critical load of pelvic fracture was 3.8 kN. In validation against the tests of Beason et al., the peak impact force under unpadded load and padded load was 4.3 kN and 3.1 kN, respectively, while the (VC)maxwas 0.25 m/s and 0.16 m/s, respectively. Peak impact force appears to be a reasonable criterion to assess pelvic injury. Moreover, the femoral head and impactor pad play an important role in absorbing impact energy, distributing impact load, and alleviating pelvic injury.

An objective method for screening and selecting personal cooling systems based on cooling properties

A method is proposed for evaluation and selection of a personal cooling system (PCS) incorporating PCS, subject, and equipment weights; PCS run time; user task time; PCS cooling power; and average metabolic rate. The cooling effectiveness method presented is derived from first principles and allows those who select PCSs for specific applications to compare systems based on their projected use. This can lower testing costs by screening for the most applicable system. Methods to predict cooling power of PCSs are presented and are compared to data taken through standard manikin testing. The cooling effectiveness ranking is presented and validated against human subject test data. The proposed method provides significant insight into the application of PCS on humans. However, the interaction a humans with a PCS is complex, especially considering the range of clothing ensembles, physiological issues, and end use scenarios, and requires additional analysis.

Simulation of a textile sleeve on a manikin arm undergoing elbow flexion: effect of arm-sleeve friction

The effect of friction on the interaction between a protective fabric sleeve and a manikin arm undergoing elbow flexion has been investigated both numerically and experimentally. The experimental studies used a cylindrical Kevlar sleeve on the right arm of a Hybrid III crash-test dummy. A load frame was used to produce elbow flexion and to measure the force required to produce that motion. Friction was varied by performing the elbow flexion task with and without a tight-fitting white knit polyester undergarment, and friction coefficients were determined experimentally. Corresponding numerical simulations using LS-DYNA were also performed, with the textile sleeve represented by orthotropic shell elements with geometric non-linearity based on experimental literature data. The results show that the presence of the Kevlar sleeve significantly increases the force required to execute elbow flexion, but that the addition of the friction-reducing undergarment reduces the flexion force generated by the Kevlar sleeve. Furthermore, this behavior can be effectively captured by the numerical simulation. These results demonstrate the possibility of direct simulation of the mechanical burden generated by protective clothing, which could lead to computational design of protective garments with improved comfort, and reduced reliance on human subject testing.

Human-inspired feedback synergies for environmental interaction with a dexterous robotic hand

Effortless control of the human hand is mediated by the physical and neural couplings inherent in the structure of the hand. This concept was explored for environmental interaction tasks with the human hand, and a novel human-inspired feedback synergy (HFS) controller was developed for a robotic hand which synchronized position and force feedback signals to mimic observed human hand motions. This was achieved by first recording the finger joint motion profiles of human test subjects, where it was observed that the subjects would extend their fingers to maintain a natural hand posture when interacting with different surfaces. The resulting human joint angle data were used as inspiration to develop the HFS controller for the anthropomorphic robotic hand, which incorporated finger abduction and force feedback in the control laws for finger extension. Experimental results showed that by projecting a broader view of the tasks at hand to each specific joint, the HFS controller produced hand motion profiles that closely mimic the observed human responses and allowed the robotic manipulator to interact with the surfaces while maintaining a natural hand posture. Additionally, the HFS controller enabled the robotic hand to autonomously traverse vertical step discontinuities without prior knowledge of the environment, visual feedback, or traditional trajectory planning techniques.

Energy-efficient comfort with a heated/cooled chair: Results from human subject tests

A novel heated/cooled chair was evaluated for its effect on thermal sensation and comfort. The chair is exceptionally efficient, allowing standalone battery operation over long periods. Its capabilities at providing comfort needed to be established.Twenty-three college students participated in 69 2.25-h tests. Four heated/cooled chairs were placed in an environmental chamber resembling an office environment. The chamber temperatures were 16 °C, 18 °C and 29 °C. During the tests the subjects had full control of the chair power through a knob located on the chair. The heated/cooled-chair results could be compared to those of conventional mesh and cushion chairs tested in the same three environmental conditions in a previous study, as well as to a thermoelectrically heated and cooled chair.Subjective responses for thermal sensation and comfort were obtained at 15-min intervals. The results show that the heated/cooled chair strongly influences the subjects’ thermal sensation and improves thermal comfort and perceived air quality. No significant differences were found between men and women. The chair provided comfortable conditions for 92% of the subjects in a range of temperatures from 18 °C to 29 °C.

Time-lapse imaging of human heart motion with switched array UWB radar.

Radar systems for detection of human heartbeats have mostly been single-channel systems with limited spatial resolution. In this paper, a radar system for ultra-wideband (UWB) imaging of the human heart is presented. To make the radar waves penetrate the human tissue the antenna is placed very close to the body. The antenna is an array with eight elements, and an antenna switch system connects the radar to the individual elements in sequence to form an image. Successive images are used to build up time-lapse movies of the beating heart. Measurements on a human test subject are presented and the heart motion is estimated at different locations inside the body. The movies show rhythmic motion consistent with the beating heart, and the location and shape of the reflections correspond well with the expected response form the heart wall. The spatial dependent heart motion is compared to ECG recordings, and it is confirmed that heartbeat modulations are seen in the radar data. This work shows that radar imaging of the human heart may provide valuable information on the mechanical movement of the heart.

Evaluation of variability in real-ear attenuation testing using a unique database—35 years of data from a single laboratory

The gold standard in measuring hearing protector attenuation since the late 1950s has been real-ear attenuation at threshold (REAT). Though well understood and standardized both in the U. S. (ANSI S3.19-1974 and ANSI S12.6-2008) and internationally (ISO 4869-1:1990), and known to provide valid and reliable estimates of protection for the test panel being evaluated, an area that is not clearly defined is the variability of the test measurements within a given laboratory. The test standards do provide estimates of uncertainty, both within and between laboratories, based on limited test data and interlaboratory studies, but thus far no published within-laboratory data over numerous tests and years have been available to provide empirical support for variability statements. This paper provides information from a one-of-a-kind database from a single laboratory that has conducted nearly 2500 studies over a period of 35 years in a single facility, managed by the same director (the lead author). Repeat test data on a controlled set of samples of a foam earplug, a premolded earplug, and two different earmuffs, with one of the data sets comprising 25 repeat tests over that 35-year period, will be used to demonstrate the inherent variability of this type of human-subject testing.

An experimental and numerical study on the effect of air terminal types on the performance of stratum ventilation

The purpose of this paper is to investigate the effect of air terminal types on the design and performance of stratum ventilation. Four types of air terminals, including circular diffusers, square diffusers, perforated diffusers and double deflection grilles were studied by experimental and numerical methods. Human subject tests of thermal sensations and comfort were conducted under various experimental conditions. The performance of stratum ventilation was evaluated by six indicators: airflow pattern, temperature distribution, air diffusion performance index, thermal sensation and comfort feedback, local mean age of air and CO2 concentration. The results indicate that air terminal type has a significant effect on airflow pattern. Good air diffusion performances were achieved with four types of diffusers. More than 80% subjects felt thermally comfortable with circular and perforated diffusers. In terms of air quality, the local mean age of air for the circular diffuser case was the oldest, while the CO2 concentration in the breathing zone was the second lowest and the most uniform for this case. Thus, the circular diffuser can be a better choice for stratum ventilation.

Optimized Lower Leg Injury Probability Curves From Postmortem Human Subject Tests Under Axial Impacts

Objective: Derive optimum injury probability curves to describe human tolerance of the lower leg using parametric survival analysis.Methods: The study reexamined lower leg postmortem human subjects (PMHS) data from a large group of specimens. Briefly, axial loading experiments were conducted by impacting the plantar surface of the foot. Both injury and noninjury tests were included in the testing process. They were identified by pre- and posttest radiographic images and detailed dissection following the impact test. Fractures included injuries to the calcaneus and distal tibia–fibula complex (including pylon), representing severities at the Abbreviated Injury Score (AIS) level 2+. For the statistical analysis, peak force was chosen as the main explanatory variable and the age was chosen as the covariable. Censoring statuses depended on experimental outcomes. Parameters from the parametric survival analysis were estimated using the maximum likelihood approach and the dfbetas statistic was used to identify overly influential samples. The best fit from the Weibull, log-normal, and log-logistic distributions was based on the Akaike information criterion. Plus and minus 95% confidence intervals were obtained for the optimum injury probability distribution. The relative sizes of the interval were determined at predetermined risk levels. Quality indices were described at each of the selected probability levels.Results: The mean age, stature, and weight were 58.2 ± 15.1 years, 1.74 ± 0.08 m, and 74.9 ± 13.8 kg, respectively. Excluding all overly influential tests resulted in the tightest confidence intervals. The Weibull distribution was the most optimum function compared to the other 2 distributions. A majority of quality indices were in the good category for this optimum distribution when results were extracted for 25-, 45- and 65-year-olds at 5, 25, and 50% risk levels age groups for lower leg fracture. For 25, 45, and 65 years, peak forces were 8.1, 6.5, and 5.1 kN at 5% risk; 9.6, 7.7, and 6.1 kN at 25% risk; and 10.4, 8.3, and 6.6 kN at 50% risk, respectively.Conclusions: This study derived axial loading-induced injury risk curves based on survival analysis using peak force and specimen age; adopting different censoring schemes; considering overly influential samples in the analysis; and assessing the quality of the distribution at discrete probability levels. Because procedures used in the present survival analysis are accepted by international automotive communities, current optimum human injury probability distributions can be used at all risk levels with more confidence in future crashworthiness applications for automotive and other disciplines.

Modeling the comfort effects of short-wave solar radiation indoors

Exposure to sunlight indoors produces a substantial effect on an occupant's comfort and on the air conditioning energy needed to correct for it, yet has in the past not been considered in design or in thermal comfort standards. A public online model of the effects of solar radiation on human heat gain and comfort has been developed to make this possible. SolarCal is a whole-body model for ease of use in early design. Its predictions compare closely (<0.1 PMV mean absolute error) to results of a human subject test. It can be used to determine the allowable transmittance of fenestration in a perimeter office.