NASA now has a focused mission for space exploration. We will continue to use ground based analogs and simulators, the Space Shuttle and the International Space Station as research and development platforms, but the challenges of time, distance and very hostile environments raise the challenges to human factors engineering designers to an even greater level. We will have a new generation of vehicles, equipment, habitats and space suits; operations and activity management will present novel scheduling, training and task allocation opportunities. The safety stakes will also be higher and the cold euphemisms of risk management will require some humanization, both for the crew and the public. Space vehicle launch, docking, navigation and landing will require complex interactions between automation and human operators. Commanders and pilots will require considerable simulator training and will be expected to perform flawlessly despite the debilitating exposure to extended time in space. Physical tasks on planetary surfaces will require protective suits that allow explorers to function effectively without the risk of excessive fatigue. Deviations from our familiar 24 hour day night cycle will demand innovative countermeasures if crew members are not to succumb to performance decrements due to cumulative sleep deprivation. Operation of complex life support, transportation, emergency response and scientific systems will require the development of effective and efficient job aids and procedures. Planetary surface habitats will be designed with the life support systems and home comforts necessary for long duration tenure. Finally, the safety of the human crew will be paramount and will require robust hybrid human-robotic systems, activity schedules and operations management. The NASA space human factors community is addressing these challenges by observing the performance of crew members in analogs, simulators and real missions and supporting this activity by basic and applied research in NASA laboratories and in collaboration with external scientists. The presentations in this panel will describe some of the current efforts to support this focused NASA exploration mission.