The dramatic increase in the use of Artificial Intelligence (AI) in workplaces around the world can be attributed to the potential for increased profitability. While AI has numerous useful applications and can help speed up business processes or transform systems, its use in human resources (HR) processes and systems presents a complex series of pros and cons requiring organizational leaders to tread with caution. AI is helping transform the nature of jobs and workplace employment relationships. Robots can replace humans as employees, while platforms are able to supervise human employees. However, organizations employing AI to manage their people will need to be accountable for improving the employee experience, increasing investments in their skill development, building organizational competency, and enhancing transparency to ensure responsible usage. In this paper, we discuss the possible misuses of AI algorithms and argue that these could adversely impact the organization’s human resources, if not devised and implemented with caution. In reviewing the literature linking AI and HR through the ethical lens, we discuss how AI is now an integral part of the HR architecture, and why it must be deployed with caution. If AI is to co-exist with humans, organizations will need to assure that their corporate philosophies honor their obligations to the social contract with stakeholders by implementing responsible HR policies and practices.