Human Psychopharmacology Research Articles

Pharmacology of Sleep

Human Psychopharmacology: Clinical and ExperimentalVolume 11, Issue 3 p. 257-257 Book Review Pharmacology of Sleep Ian Hindmarch, Ian Hindmarch GodalmingSearch for more papers by this author Ian Hindmarch, Ian Hindmarch GodalmingSearch for more papers by this author First published: May 1996 https://doi.org/10.1002/(SICI)1099-1077(199605)11:3<257::AID-HUP794>3.0.CO;2-LAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume11, Issue3May 1996Pages 257-257 RelatedInformation

Current awareness in human psychopharmacology

Current awareness in human psychopharmacology

Pharmacology of Sleep

Human Psychopharmacology: Clinical and ExperimentalVolume 11, Issue 3 p. 257-257 Book Review Pharmacology of Sleep Ian Hindmarch, Ian Hindmarch GodalmingSearch for more papers by this author Ian Hindmarch, Ian Hindmarch GodalmingSearch for more papers by this author First published: May 1996 https://doi.org/10.1002/(SICI)1099-1077(199605)11:3<257::AID-HUP794>3.0.CO;2-LAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume11, Issue3May 1996Pages 257-257 RelatedInformation

Current awareness in human psychopharmacology

Human Psychopharmacology: Clinical and ExperimentalVolume 11, Issue 2 p. 151-158 Miscellaneous Current awareness in human psychopharmacology First published: March 1996 https://doi.org/10.1002/hup.470110202AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume11, Issue2March 1996Pages 151-158 RelatedInformation

Whither lithium?

Human Psychopharmacology: Clinical and ExperimentalVolume 11, Issue 2 p. 81-84 Editorial Whither lithium? Mogens Schou, Mogens Schou The Psychiatric Hospital, 2 Skovagervej, DK-8240 Risskov, DenmarkSearch for more papers by this author Mogens Schou, Mogens Schou The Psychiatric Hospital, 2 Skovagervej, DK-8240 Risskov, DenmarkSearch for more papers by this author First published: March 1996 https://doi.org/10.1002/(SICI)1099-1077(199603)11:2<81::AID-HUP758>3.0.CO;2-TCitations: 2AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume11, Issue2March 1996Pages 81-84 RelatedInformation

Masthead

Human Psychopharmacology: Clinical and ExperimentalVolume 11, Issue 2 p. fmi-fmi MastheadFree Access Masthead First published: March 1996 https://doi.org/10.1002/hup.470110201AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume11, Issue2March 1996Pages fmi-fmi RelatedInformation

Objective analysis of placebo response by substitution tests

Human Psychopharmacology: Clinical and ExperimentalVolume 11, Issue 2 p. 145-146 Correspondence Objective analysis of placebo response by substitution tests A.K. Agarwal, A.K. Agarwal Department of Pharmacology, Christian Medical College, Ludhiana-141008, IndiaSearch for more papers by this authorM.V. Natu, Corresponding Author M.V. Natu Department of Pharmacology, Christian Medical College, Ludhiana-141008, IndiaDepartment of Pharmacology, Christian Medical College, Ludhiana-141008, IndiaSearch for more papers by this author A.K. Agarwal, A.K. Agarwal Department of Pharmacology, Christian Medical College, Ludhiana-141008, IndiaSearch for more papers by this authorM.V. Natu, Corresponding Author M.V. Natu Department of Pharmacology, Christian Medical College, Ludhiana-141008, IndiaDepartment of Pharmacology, Christian Medical College, Ludhiana-141008, IndiaSearch for more papers by this author First published: March 1996 https://doi.org/10.1002/(SICI)1099-1077(199603)11:2<145::AID-HUP760>3.0.CO;2-EAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume11, Issue2March 1996Pages 145-146 RelatedInformation

Human psychopharmacology of hoasca, a plant hallucinogen used in ritual context in Brazil.

A multinational, collaborative, biomedical investigation of the effects of hoasca (ayahuasca), a potent concoction of plant hallucinogens, was conducted in the Brazilian Amazon during the summer of 1993. This report describes the psychological assessment of 15 long-term members of a syncretic church that utilizes hoasca as a legal, psychoactive sacrament as well as 15 matched controls with no prior history of hoasca ingestion. Measures administered to both groups included structured psychiatric diagnostic interviews, personality testing, and neuropsychological evaluation. Phenomenological assessment of the altered state experience as well as semistructured and open-ended life story interviews were conducted with the long-term use hoasca group, but not the hoasca-naive control group. Salient findings included the remission of psychopathology following the initiation of hoasca use along with no evidence of personality or cognitive deterioration. Overall assessment revealed high functional status. Implications of this unusual phenomenon and need for further investigation are discussed.

Oral anticoagulation under the influence of reversible and irreversible MAO inhibitors

Human Psychopharmacology: Clinical and ExperimentalVolume 11, Issue 1 p. 69-70 Correspondence Oral anticoagulation under the influence of reversible and irreversible MAO inhibitors H. Hampel, Corresponding Author H. Hampel National Institutes of Health, National Institute on Aging, Bethesda, MD, USADr H. Hampel, 3401 38th Street, 620, N.W., Washington DC 20016, USA.Search for more papers by this authorC. Berger, C. Berger Department of Psychiatry, University of Munich, D-80336 Munich, GermanySearch for more papers by this authorH.-J. Möller, H.-J. Möller Department of Psychiatry, University of Munich, D-80336 Munich, GermanySearch for more papers by this authorF. Müller-Spahn, F. Müller-Spahn Department of Psychiatry, University of Basle, CH-4025 Basle, Switzerland.Search for more papers by this author H. Hampel, Corresponding Author H. Hampel National Institutes of Health, National Institute on Aging, Bethesda, MD, USADr H. Hampel, 3401 38th Street, 620, N.W., Washington DC 20016, USA.Search for more papers by this authorC. Berger, C. Berger Department of Psychiatry, University of Munich, D-80336 Munich, GermanySearch for more papers by this authorH.-J. Möller, H.-J. Möller Department of Psychiatry, University of Munich, D-80336 Munich, GermanySearch for more papers by this authorF. Müller-Spahn, F. Müller-Spahn Department of Psychiatry, University of Basle, CH-4025 Basle, Switzerland.Search for more papers by this author First published: January 1996 https://doi.org/10.1002/(SICI)1099-1077(199601)11:1<69::AID-HUP737>3.0.CO;2-JAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume11, Issue1January 1996Pages 69-70 RelatedInformation

Current awareness in human psychopharmacology

Current awareness in human psychopharmacology

Benzodiazepine Site Pharmacokinetic/Pharmacodynamic Quantification in Man: Direct Measurement of Drug Occupancy and Effects on the Human Brain In Vivo

To date, the study of the relationship between drug occupancy and action in the brain has had to rely on the use of either animal models or of indirect kinetic measures in man, e.g. serum concentrations of unbound drug (as a measure of “free” drug in brain). We describe the first set of experiments which directly measure agonist-induced changes in both pharmacodynamic effects and pharmacokinetic parameters simultaneously and which demonstrate the feasibility of these studies in man. Five healthy volunteers each had two PET scans using [11C]flumazenil (a radiolabelled benzodiazepine site antagonist) as part of a study investigating kinetic models and the relationship between occupancy and effect of benzodiazepine site ligands. In both studies the [11C]flumazenil was displaced from the brain by an infusion of midazolam administered i.v. 30 min into the scan. In one study a higher dose of midazolam was administered than in the other (range 12.5–50 μg/kg). Time-activity curves of the concentration of radioligand were derived in 17 different brain regions using a stereotactic automatic method of region selection. We demonstrated that there are significant differences in an index of occupancy, induced by the two different doses of midazolam, both across brain regions and within subjects. There was a significant correlation between measured occupancy index change and pharmacodynamic effects as measured by the peak change in beta1 spectral power observed on EEG. There was no significant correlation between dose administered and EEG changes; plasma concentrations of midazolam were correlated with the occupancy index and with the EEG measures. In addition, we have demonstrated that a non-regional total index of brain occupancy can be obtained by analysing the non-tomographic data obtained with the PET scanner (total radioactivity counts head curve) and that this index shows significant correlations both with the dose administered and with the pharmacodynamic measure. This last finding validates the use of other non-tomographic counting techniques (Malizia et al., 1995a) where an index of displacement can be obtained after the administration of less than 1% of the dose of radiation needed for a PET study. These studies are likely to be useful in human psychopharmacology, in particular in the assessment of tolerance and of putative changes in benzodiazepine sensitivity in anxiety disorders. The same principles can be applied to other ligand studies and will be useful to validate current PK/PD models. Copyright © 1996 Elsevier Science Ltd

Current awareness in human psychopharmacology

Human Psychopharmacology: Clinical and ExperimentalVolume 10, Issue 6 p. 497-504 Current Awareness Current awareness in human psychopharmacology First published: November/December 1995 https://doi.org/10.1002/hup.470100619AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume10, Issue6November/December 1995Pages 497-504 RelatedInformation

Clinical psychopharmacology. Edited by David J. King. Gaskell Press, London, 1995. pp. 534. £20.00

Human Psychopharmacology: Clinical and ExperimentalVolume 10, Issue 6 p. 495-495 Book Review Clinical psychopharmacology. Edited by David J. King. Gaskell Press, London, 1995. pp. 534. £20.00 David Healy, David Healy BangorSearch for more papers by this author David Healy, David Healy BangorSearch for more papers by this author First published: November/December 1995 https://doi.org/10.1002/hup.470100616AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume10, Issue6November/December 1995Pages 495-495 RelatedInformation

Depression and mania—from neurobiology to treatment. G. L. Gessa, W. Fratta, L. Pari and G. Serra Vol. 49. Advances in biochemical psychopharmacology. Raven Press, New York, 1995. $91.00. ISBN 0‐7817‐0307‐7

Human Psychopharmacology: Clinical and ExperimentalVolume 10, Issue 6 p. 495-496 Book Review Depression and mania—from neurobiology to treatment. G. L. Gessa, W. Fratta, L. Pari and G. Serra Vol. 49. Advances in biochemical psychopharmacology. Raven Press, New York, 1995. $91.00. ISBN 0-7817-0307-7 B. E. Leonard, B. E. Leonard GalwaySearch for more papers by this author B. E. Leonard, B. E. Leonard GalwaySearch for more papers by this author First published: November/December 1995 https://doi.org/10.1002/hup.470100617AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume10, Issue6November/December 1995Pages 495-496 RelatedInformation

Meyler's side effects of drugs, 12th edition. Edited by M. N. G. Dukes. Elsevier Science, Amsterdam, 1992. £297. ISBN 0‐444‐8952‐8

Human Psychopharmacology: Clinical and ExperimentalVolume 10, Issue 6 p. 494-494 Book Review Meyler's side effects of drugs, 12th edition. Edited by M. N. G. Dukes. Elsevier Science, Amsterdam, 1992. £297. ISBN 0-444-8952-8 David Healy, David Healy BangorSearch for more papers by this author David Healy, David Healy BangorSearch for more papers by this author First published: November/December 1995 https://doi.org/10.1002/hup.470100615AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume10, Issue6November/December 1995Pages 494-494 RelatedInformation

Announcement

Human Psychopharmacology: Clinical and ExperimentalVolume 10, Issue 6 p. 511-511 Announcement Announcement First published: November/December 1995 https://doi.org/10.1002/hup.470100620AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume10, Issue6November/December 1995Pages 511-511 RelatedInformation

The role of nitric oxide in physiology and pathophysiology. Edited by H. Koprowski and H. Maeda. Springer‐Verlag, Berlin, 1995. pp. 90. DM 139, S. Fr. 133.50. ISBN 3‐540‐58214‐2

Human Psychopharmacology: Clinical and ExperimentalVolume 10, Issue 6 p. 496-496 Book Review The role of nitric oxide in physiology and pathophysiology. Edited by H. Koprowski and H. Maeda. Springer-Verlag, Berlin, 1995. pp. 90. DM 139, S. Fr. 133.50. ISBN 3-540-58214-2 Maeve Caldwell, Maeve Caldwell GalwaySearch for more papers by this author Maeve Caldwell, Maeve Caldwell GalwaySearch for more papers by this author First published: November/December 1995 https://doi.org/10.1002/hup.470100618AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume10, Issue6November/December 1995Pages 496-496 RelatedInformation

Current awareness in human psychopharmacology

Human Psychopharmacology: Clinical and ExperimentalVolume 10, Issue 5 p. 437-444 Current Awareness Current awareness in human psychopharmacology First published: September/October 1995 https://doi.org/10.1002/hup.470100512AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume10, Issue5September/October 1995Pages 437-444 RelatedInformation

The NMDA receptor, second edition. Edited by G. L. Collinridge, and J. C. Watkins. Oxford University Press, Oxford, 1994. pp. 503. £30. ISBN 019262502 0 (Pbk)

Human Psychopharmacology: Clinical and ExperimentalVolume 10, Issue 5 p. 435-435 Book Review The NMDA receptor, second edition. Edited by G. L. Collinridge, and J. C. Watkins. Oxford University Press, Oxford, 1994. pp. 503. £30. ISBN 019262502 0 (Pbk) M. Maginn, M. Maginn GalwaySearch for more papers by this author M. Maginn, M. Maginn GalwaySearch for more papers by this author First published: September/October 1995 https://doi.org/10.1002/hup.470100511AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume10, Issue5September/October 1995Pages 435-435 RelatedInformation

Current awareness in human psychopharmacology

Human Psychopharmacology: Clinical and ExperimentalVolume 10, Issue 4 p. 359-366 Current Awareness Current awareness in human psychopharmacology First published: July/August 1995 https://doi.org/10.1002/hup.470100425AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume10, Issue4July/August 1995Pages 359-366 RelatedInformation