Virtual humans (VHs) are gaining increasing attention in various fields, including games and cultural heritage and technological contexts including virtual reality and augmented reality. Recently, since VHs can simulate human-like behavior, VHs have been proposed as virtual assistants (VAs) for all sorts of education and training applications, including applications focused on the improvement of quality of life (QoL) and well-being. In this research work, we consider the quality and efficiency of VHs implemented as part of the MyHealthWatcher project, which focuses on the monitoring of health-related parameters of elder users to improve their QoL and self-management of chronic conditions. To validate our hypothesis that the increased quality of the VH has a positive effect on user satisfaction and user quality of interaction with the system, we developed and integrated into the MyHealthWatcher system two VH variations. The first was developed with mainstream technologies and the second was developed using a professional pipeline. The two variations developed were assessed by representative target users through a between-subject focus group study. The development and validation process of the two variations allowed us to draw valuable conclusions, which are discussed in this paper.