This study was conducted to investigate the effect of the variabIe Dependency Ratio, Affirmation Physical DAK, Gross RegionaI Domestic Product on the Human Development lndex in Underdeveloped Regions in West Papua Province years 2019-2023. The methodlused the studyiis paneI dataaregression analysis with the Fixed Effect ModeI (FEM) estimation. The data used in this study is the 2019-2023 period with 8 districts included in the category of disadvantaged areas. The results obtained indicate the dependency ratio has a significantlnegative effect at the Human DeveIopment lndex, if the dependency ratio decreases, the Human Development Index will increase. For DAK Physical Affirmation has no influence on the Human Development Index, because there are still development inequality in 8 underdeveloped regions in West Papua Province due to natural topography, and socio-cultural factors. While the GRDP variable own a positive as well as significant infIuence, imediately from GRDP increases, the Development Index will also increase because GRDP at constant prices reflects the economic growth of a region.