HPMC K4M Research Articles

The Development of Alternative Dosage Form for Creatine Monohydrate: A Floating Tablet

Creatine monohydrate has been developed as a neuroprotective agent and can penetrate in vitro model of the blood-brain barrier. However, its delivery is hampered by its limited capacity of creatine transporter. The floating system is known to increase the residence time of drugs in the stomach; thus, the active substances can be absorbed more optimally. Therefore, this study is aimed to develop creatine monohydrate floating tablets by optimizing the proportion of HPMC K100M and NaHCO2 and evaluating the quality of floating tablets. The formula was designed Simplex Lattice Design method. Tablets were prepared by the wet granulation method and evaluated for granule and tablet parameters. The results showed that HPMC K100M significantly increased flow time, absorption rate, hardness, floating time, swelling index; decreased index tap, fragility, and floating lag time. Meanwhile, an increase in NaHCO2 significantly affects an increase in floating lag time. The optimum formula obtained was 18.87% HPMC K100M and 21.12% NaHCO2. Verification of the optimum formula showed that tablet parameters were not significantly different from the predicted formula. The studies suggest that this prototype can be developed to increase creatine residence time in the stomach.

Pre-exposure prophylactic mucoadhesive sodium alginate microsphere laden pessaries for intravaginal delivery of tenofovir disoproxil fumarate

The research aimed to develop novel bioadhesive sodium alginate (Na-Alg) microspheres laden pessaries for intravaginal delivery of tenofovir disoproxil fumarate (TDF), to overcome limitations of conventional dosage forms. Twelve batches of microspheres formulated by emulsification gelation method indicated that drug-polymer ratios and polymer type affected particle size, drug release, and entrapment efficiency (%EE). Microspheres of batch EH-8 with drug: polymer ratio of 1:4 containing equal amounts of Na-Alg and HPMC K100M displayed optimal %EE (62.09 ± 1.34 %) and controlled drug release (97.02 ± 4.54 % in 12 h). Particle size analysis in Matersizer indicated that microspheres (EH-8) displayed a surface-mean diameter of 11.06 ± 0.18 μm. Ex-vivo mucoadhesion studies on rabbit mucosa indicated that microspheres (EH-8) adhered well for 12 h. Microspheres integrated into pessaries displayed a sustained release profile (95.31 ± 1.37 % in 12 h) in simulated vaginal fluid. In vivo studies in rabbits indicated that pessaries displayed a significantly higher Cmax (41.18 ± 3.57 ng/mL) (P < 0.005) and reduced Tmax (1.00 ± 0.01 h) (P < 0.0001) of TDF concentrations in vaginal fluid compared to oral tablets. The microparticulate pessaries with the ability to elicit higher vaginal fluid levels in the crucial initial hours of insertion demonstrates a potential novel platform to offer better self-protection to HIV-negative women against HIV during sexual intercourse.

Formulation and evaluation of floating controlled drug delivery of anti-ulcer drug loaded microballoons

An attempt has been made to develop floating drug delivery system for improving the drug bioavailability by prolongation of gastric residence time of Famotidine in the stomach. The floating microballoons were prepared using polymer Eudragit RS100, HPMC K100M and Ethyl Cellulose. Famotidine was used as the model drug. Nine formulations (F1 to F9) were prepared by varying the ratio of polymers. The prepared Famotidine loaded micro balloons were characterized for percentage yield, particle size analysis, surface morphology, micromeritic properties, drug entrapment efficiency, buoyancy studies and in-vitro drug release. The formulated micro balloons were free flowing. The micro balloons with Eudragit RS100 showed higher buoyancy when compared with HPMC K100M and Ethyl Cellulose. On the basis of micromeritic properties, particle size, percentage yield, morphology, buoyancy study, drug entrapment, optimum in-vitro drug release and satisfactory release kinetics, formulation F2 was selected as an optimum formulation

Formulation and evaluation of topical gels incorporated with solid dispersions of an antiinflammatory drug

Formulation and development of a most effective product from poorly soluble drugs is one of the most challenging tasks in pharmaceutical industries. Solid dispersion is an efficient solubility enhancement method to overcome the solubility problem. The aim of this study was to formulate topical gels incorporated with solid dispersion of Aceclofenac to enhance permeability through the skin. Aceclofenac solid dispersions were prepared using suitable hydrophilic carriers to increase its aqueous solubility. In this study, solid dispersions of Aceclofenac were prepared by solvent evaporation and co-grinding method with two different hydrophilic carriers such as polyvinyl pyrrolidone (PVPk-30), and HPMC E15 LV. These were used in the ratio of (drug: carrier) 1: 1, 1:2 &amp; 1:3 respectively. Evaluation parameters for formulation optimization were drug content, percentage practical yield, DSC, , in-vitro dissolution studies &amp; FTIR. The optimized SD (F3) solid dispersion is incorporated in topical gels of different concentrations prepared by using two gelling agents such as Carbopol 934 and HPMC K100M. From the results of in-vitro dissolution studies it was found that formulation F3 containing PVP k30 (1 : 3 ratio of drug: PVP k30) shows a higher dissolution rate compared with other formulations and pure drug. Optimized solid dispersion was incorporated into topical gels prepared by using two gelling agents in different concentrations. From the stability data obtained, no significant changes in physical appearance, viscosity, pH, and drug contents were seen. The present research work could be concluded as a successful production of topical gels incorporated with Aceclofenac solid dispersion. Improvement in aqueous solubility and thereby greater skin permeation is expected

Preparation and evaluation of floating drug delivery system (fdds) containing an antiviral drug

Acyclovir, an antiviral drug has low oral bioavailability of about 15-30%. It shows more absorption in the upper gastro intestinal tract. The main objective is to evaluate the potential of floating alginate beads as a drug carrier for acyclovir to prolong gastric residence time of drug in its absorption window. Floating beads were prepared from sodium alginate solution containing CaCO3 as gas-forming agent using Ionotropic gelation method. To overcome the limitation of drug leaching during preparation and to have improved sustained release characteristics, alginate beads were prepared with the addition of polymers like Hydroxy propyl methyl cellulose (HPMC K4M), Eudragit RL 100 and Xanthan gum. Beads were also prepared by using Pectin (polyelectrolyte) containing cross linking solution. The compatibility of drug with the polymer was confirmed through the FT-IR studies. The prepared beads were evaluated for percentage drug loading, entrapment efficiency, surface morphology and in vitro release characteristics to know the effect of addition of these polymers to alginate solution and the addition of Pectin to cross linking solution. Pectin treated beads prepared with Xanthan gum &amp; Pectin not only showed improved percentage drug loading but also exhibited sustained drug release in the pH 1.2. So these floating alginate beads may act as a promising carrier for acyclovir to improve its oral bioavailability.

Formulation and Evaluation of Nifedipine Bilayer Floating Tablets

In the present investigation concern, the formulation and evaluation of bilayer floating tablet of Nifedipine which after an oral administration increase gastric residence time, to increase the bioavailability. Nifedipine is the Calcium channel blocker of the dihydropyridine type which used in angina pectoris and hypertension. It has a half-life of 2-4hours and bioavailability of 45-56%. It is advantageous to formulate bilayer floating tablet of Nifedipine helps to increase bioavailability, reduce dosing frequency, and reach maximum plasma concentration rapidly. Bilayer floating tablets comprised of two layers, immediate and sustain release layers. The immediate release layer is comprised of super disintegrating agent Karaya gum, and sustain release layer comprised of low density release retardant polymers like HPMC K4M and Guar gum; and sodium bicarbonate and citric acid gas generating agents. The prepared powder mixtures were subjected to FT-IR for all interaction. The tablets were prepared by direct compression. First, the powder blends of sustained release layer was pre-compressed and then powder blends of immediate release layer was added. Hardness, friability, drug content, floating lag time, total floating time, swelling index and in-vitro drug release were evaluated. In the present study, it was found that formulation F4 containing HPMC K4M and Guar gum in the ratio of 2:1 showed maximum drug release. The release data were adjusted to various mathematical models such as Higuchi, 1st order and zero order to evaluate the kinetics and mechanisms of the drug release and it was best suited for the Higuchi model. There were no notable changes in stability studies.

Utilizing Natural Mucoadhesive Polymers for Development of Nanoparticle Based Cilnidipine Buccal Films

The less oral bioavailability of Cilnidipine is primarily due to low solubility leads to reduced therapeutic efficacy. The study aimed to develop mucoadhesive buccal films to increase the bioavailability resulting in improved efficacy of this pooly soluble drug trough the buccal mucosa for the treatment of hypertension. Buccal films of Cilnidipine nanoparticles were developed by using different concentration of polymers such as HPMS K4M, HPMC K15M and Carbopol 934 by solvent casting technique. The developed films were characterized for the surface texture, thickness, surface pH, folding endurance, swelling index, content uniformity, mucoadhesive strength, moisture loss, moisture absorption, drug release, ex-vivo drug permeation and stability studies. F9 formulation was optimized as best formulation based on the physico chemical parameters, in vitro dissolution and ex-vivo permeation studies. The result indicates that the drug releases from the buccal films are slow and prolonged over the period of 12 h. There was no significance changes were observed during the stability studies indicates that, the prepared buccal films are stable. Hence, mucoadhesive buccal films can be used as an alternative particularly in the bed time with improved absorption of the dug through buccal mucosa, resulting in better bioavailability and therapeutic efficacy.

Formulation and Evaluation of Sustained Release Matrix Tablet of Valsartan

The aim of this study was to develop antihypertensive matrix tablets with sustained release of valsartan, an angiotensin type II receptor antagonist, using hydroxypropyl methylcellulose and combination of ethyl cellulose material as matrix in different proportions by wet granulation. The granules are evaluated by tapped density, bulk density, angle of repose and compressibility index. The tablets are tested for friability, hardness, weight variation and in vitro release. The granules showed good flow properties and compressibility properties and all tablet formulations showed pharmaceutical properties. The result of dissolution study indicate that the formulation prepared by combination of high grade HPMC K100M and ethyl cellulose showed maximum drug release for 12hrs and high drug release around 98.56% i.e., Formulation F8 is the best formulation.

EFFECT OF VARIOUS SUSTAINED RELEASE POLYMERS ON FLOATING TABLETS OF CARVEDILOL PHOSPHATE-A COMPARATIVE STUDY

Objective: This study aimed to develop floating tablets of Carvedilol phosphate containing various excipients such as HPMC K100M, Carbopol, Polyox WSR, HPMC K4M, and sodium bicarbonate to generate gas. Additionally, the impact of DCP, spray dried lactose, and HPβCD on drug release was investigated. Methods: A total of eighteen formulations were prepared using the direct compression method and evaluated for hardness, drug content, friability, floating lag time, floatation time and drug release properties. Results: FTIR analysis confirmed that there were no chemical interactions between Carvedilol phosphate and the excipients used in the formulation of the floating tablets. Most of the Carvedilol phosphate floating tablets, except for F9 and F10, did not disintegrate in water, alkaline fluids (pH 7.4), or acidic aqueous solutions (pH 1.2). These tablets exhibited satisfactory quality attributes in terms of hardness, drug content, and friability, making them suitable for sustained release. The floating lag time of the tablets ranged from 25 seconds to 34 min, while the floating duration varied from 2 to 24 h. The drug release from the tablets was gradual and sustained over 12 h, depending on the composition of the tablets. Polyox WSR (F9 and F10) resulted in a rapid drug release, whereas an increase in the polymer concentration led to a decrease in the rate of drug release across all formulations. Conclusion: The study reveals that the use of hydrophilic polymers enhanced the drug release, whereas hydrophobic polymers decreased the drug release. As such, formulations, F11, F15, and F16, which gave 100% drug release within 12 h are finalized as the optimized formulations of Carvedilol phosphate floating tablet.

Formulation and in vitro Evaluation of Verapamil Hydrochloride Floating Tablets

The present research work aims to formulate and evaluate novel sustained-discharge floating tablets of verapamilhydrochloride (VPH) which is used for the treatment of hypertension. We aim to use a direct compression technique to formulatethe floating tablets. The characterization of the formulation of VPH was carried out by employing FT-IR and DSC studies, whichshowed that there was no chemical interaction between the drug and polymers, such as HPMC K100M, chitosan, and sodiumalginate. The tablets are designed to have good in-vitro buoyancy, and they remain afloat in the dissolution medium. The bestformulation (F7) is chosen based on its maximum drug discharge (91.91±2.25%) and drug content (97.20±2.71%) over 12h. Thedischarge kinetics of the drug from the tablets are analyzed using various mathematical models, such as zero order, first order,Higuchi, and Korsmeyer's equations. These models help explain and predict drug discharge behavior over time. The studyconcludes that a proper balance between the sustained-release polymer and the gas-forming agent is essential for efficient in-vitrobuoyancy and sustained drug discharge. Formulation F7, which utilized sodium alginate, appears to be the most promising in termsof drug discharge and content.

KARAKTERISASI DAN OPTIMASI EMULGEL NA DIKLOFENAK DENGAN METODE SIMPLEX LATTICE DESIGN

Diclofenac Na is an NSAID class of drugs that functions to treat pain and inflammation of rheumatoid arthritis, osteoarthritis or joint disease. The aim of this study is to investigate the effect of carbopol 940, HPMC K15M and propyleneglycol variations on the emulgel physical properties, carbopol concentration, HPMC, propyleneglycol to produce an optimum formula.The method used in this optimization is Simplex Lattice Design. The independent variables which include carbopol 490 , HPMC K15M , propylene glycol were then included in the expert design to obtain 16 runs. Each formula was tested for viscosity, spreadability, adhesion, pH, diffusivity and physical stability. Each parameter has a contour plot and by superimposing it can be determined the shaded area which is the area of ​​the optimum formula. The optimum formula was carried out using a one sample t-test with a 95% confidence level. Based on the results of superimposed superimposed graphic observations for the manufacture of diclofenac narium emulgel with test parameters including spreadability, viscosity, adhesion, PH, diffusion ability and stability test, the composition of Carbobol 940 0.5 - 1.22%, HPMC K-15M 3.24 - 3.77 Propylene glycol 5 - 6.26%. The results of the t-test showed that the Simplex Lattice Design equation in the formula showed results that were not significantly different, this shows the significance value of the results before treatment with treatment results &gt; 0.05. This shows that the equation is valid and the stability test is stable.

Optimizing pulsatile release of febuxostat for managing gout flares: a chronotherapeutic approach

BackgroundChronic conditions such as nocturnal asthma, cardiac disorder, diabetes mellitus, joint pain and inflammation, and hypercholesterolemia necessitate a treatment strategy that can be planned in accordance with the disease's biological clock. The early morning spike in blood plasma uric acid was associated with gout. The treatment of these symptoms may not be feasible with immediate release formulations. Modified release formulations allow for controlled and consistent levels of medication in plasma throughout the day, but do not provide additional therapeutic levels when symptoms worsen. A chronotherapeutic system of febuxostat characterized by a time of no release (lag time) followed by a quick and complete release, can be designed to overcome this. The aim of the present study was to design a pulsincap of febuxostat to release the medication as per chronological conditions.ResultsThe study commenced with the optimization of the capsule body coating to maintain its integrity over a 12-h period. Subsequently, polymers for immediate and sustained release tablets were screened, and the prepared tablets were subjected to physicochemical evaluation. For the optimization of the erodible plug, a 32 full factorial design was employed, leading to the creation of nine different polymer combinations. The response curves of HPMC K15M demonstrated a negative impact on swelling index and lag time, while displaying a positive effect on hardness. In contrast, the aloe vera, guar gum mixture exhibited significant effects on swelling index and lag time, but negatively influenced hardness. Diagnostic plots and ANOVA were utilized to confirm the significance and goodness of fit of the model. An optimized formulation was then developed based on the desirability plot. The formulated capsule, consisting of 91.71 mg of HPMC K15M and 101.56 mg of aloe vera, guar gum mixture, exhibited promising properties. Notably, it demonstrated a 70.69% swelling rate, a hardness of 5.78 kg/cm2, and an 8.57-h lag time. The pulsincap successfully met the requirement of immediate release within the first hour, followed by a pulsatile release with a lag time lasting for at least 8–10 h.ConclusionsIn conclusion, the formulation effectively reduces the threat of gout flares and enhances patient compliance due to its night-time dosing convenience.

Ion-Sensitive in situ gelling Solution containing Tobramycin for Management of Ocular Infections

Stimuli Sensitive Drug Delivery Systems have become a promising approach in the field of drug delivery and contributed by use of polymers which are able to deliver drug in response to change in surrounding environmentsuch change in temperature, pH, ionic strength, enzymes or biomolecules. Ocular drug delivery often encounters the problems of low instillation quantity of medicament and also poor residence of drug in the ocular region which decreases the efficiency of the treatment. An ineffective antibacterial treatment would lead to bigger problems like resistance. Hence the current study was undertaken to formulate Ion-sensitive in-situ ophthalmic gelling solution of Tobramycin using Sodium alginate as ion sensitive polymer. The batches were prepared by using 32 factorial designwhere sodium alginate and HPMC K4M were selected as independent variables. The evaluation of various dependent parameters like clarity, viscosity, mucoadhesion and in vitro release was done. The formulations were ensured to be sterileand isotonic. The in-situ gelation occurred when the formulation came in contact with tear fluid with good mucoadhesion and gel strength. The Tobramycin drug release study showed release over a period of more than two hours. In vivoeye irritation test was done on white rabbits.

Formulation and in-vitro evaluation of floating pulsatile drug delivery of chronotherapeutic release of h2 receptor antagonist of famotidine

In the present study famotidine floating pulsatile drug delivery system was developed. Various type and different concentrations of superdisintegrants and polymer affect the drug release. FTIR studies concluded that there is no interaction between drug and excipients. Based on disintegration time and dissolution time the formulation (F2) which contains 8% sodium starch glycollate was optimised. The optimised formulation F2 was further coated with different concentrations of HPMC K4M,HPMC K 15M and HPMC K 100M..Based on the concentration of the coating layer and solubility of the coating layer and the dissolution data the formulation (F6) which was coated with 150mg of HPMC K 15M was optimised.

Formulation and In-Vitro Evaluation of Amlodipine Besylate Floating Tablets Using Different Polymers

Gastric-retentive amlodipine besylate effervescent tablets have been developed using a variety of hydrophilic polymers. Formulations were developed using different grades of different concentrations of polymer. H. HPMC K4M, HPMC K15M, HPMC K100 and xanthan gum were used as polymeric substances. The formulated mixtures have been subjected to various pre-formulation studies and flow properties, and all formulations show that the powder mixtures have good flow properties. Among all formulations, drug release was delayed for the desired period, H. 12 hours, for the HPMC K100 formulation as a polymer. The dissolution data showed that formulations made with HPMC K100M and xanthan gum as the polymer sustained drug release for the desired period. H. 12 hours at a concentration of 150 mg. On the other hand, in formulations containing HPMC K4M, HPMC K15M as polymer failed to produce the desired drug release. Therefore, the floating drug delivery system of amlodipine using the appropriate amount of appropriate polymer can increase the activity of the drug by prolonging the gastric residence time or decreasing the floating lag time. Keywords: Gastric-retentive, amlodipine besylate, effervescent tablets, HPMC K4M

Formulation, Development and Investigation of Matrix Type Sustained Release Tablet of Antiulcer Drug by Using Soluble Polymer as a Drug Release Retarding Agent

The main goals of sustained release drug delivery are to modify the medication's biopharmaceutical, pharmacokinetic, and pharmacodynamic properties in order to lessen adverse effects, increase patient compliance, and treat the illness. The current work set out to create sustained release tablets of nizatidine (220 mg) using a wet granulation process and different concentrations of polymers such as chitosan, Kollidon SR, and HPMC K100M. Pre-formulation characteristics were examined, including medication DSC analysis and FTIR research. We assessed a number of post-compression characteristics, including content homogeneity, thickness, hardness, friability, and weight uniformity. This study demonstrated how the post-compression characteristics of the drug formulation are influenced by the concentration of polymers.

Formulation and Evaluation of Pulsatile Drug Delivery System of Dexlansoprazole

Background: A pulsatile drug delivery system is intended to deliver drugs according to the circadian rhythm, or disease cycle. PDDS prepared by pulsincap technology contain a cross-linked hard gelatin capsule filled with the optimized immediate-release tablet, sodium alginate beads. Dexlansoprazole is used to treat the signs and symptoms of gastroesophageal reflux disease (GERD), erosive esophagitis, and stomach ulcers. Objective: The objective of the research is to develop and analyse a controlled-release pulsatile medication delivery system for the treatment of peptic ulcers that contains dexlansoprazole. Method: The Pulsincap system consists of a hard gelatin capsule containing an immediate-release tablet prepared by direct compression, sodium alginate beads prepared by the ionotropic gelatin method, and a hydrogel plug made through direct compression. The hydrogel plug was prepared by using various grades of HPMC polymer. The immediate-release tablet was prepared by direct compression. Result: The results of the present FTIR studies concluded that there was no interaction between dexlansoprazole and the excipient. Based on the evaluation parameter, it was found that the F2 tablet (1:2) ratio and 2% sodium alginate beads showed better results. Polymer HPMC K15M for Hydrogel showed the desired swelling time. Conclusion: It was concluded that the preparation of a pulsatile drug delivery system for dexlansoprazole through pulsincap technology can give drug release in a pulsed manner that is first immediate release, lag time, and sustain action.

Formulation Of Benzoyl Peroxide Microsponge-Based Transdermal Gel For Acne Infection And Its Evaluation.

Benzoyl peroxide is a peroxide with antibacterial, irritating, keratolytic, comedolytic, and anti-inflammatory properties. When benzoyl peroxide is applied topically, it breaks down and releases oxygen, which kills the germs of Propionibacterium acnes. Benzoyl peroxide's irritating impact causes an increase in epithelial cell turnover, which causes the skin to peel and aids in the healing of comedones. Treatment for acne vulgaris involves the use of benzoyl peroxide. The research is aimed at studying the formulation of Microsponge gel preparation of benzoyl peroxide by using Carbopol 934 as a gelling agent and evaluation of microsponge gel formulation for its physicochemical properties. Microsponges of Anti-acne agent benzoyl peroxide drug were prepared by quasi-emulsion method, and in-vitro drug release using a suitable membrane model using a simple diffusion cell. Prior to drying, the microsponge was filtered and rinsed using distilled water. Formulation containing benzoyl peroxide and Eudragit RS100 with a ratio of 1:4 showed a high 87.5% drug content and 78.20 % yield. The drug content of the microsponge gel was found to be 84%. Microbiological study on S. aureus was conducted by the cylinder cup method and found good results. The in-vitro diffusion of microsponge formulations was sustained for 8 hours. The drug release rate for Eudragit RS-100 was reported to be 88.87% after 8 hours based on the polymer: drug ratio (4:1). The quasi-emulsion solvent diffusion method was used to successfully prepare benzoyl peroxide microsponges using Eudragit RS100, Ethyl Cellulose, and HPMC K4M as polymers. The formulations with the highest medication concentration were made with the porous polymer Eudragit RS100.

Propranolol as a Model Drug to Treat Smoking Cessation and its Formulation as a Transdermal Patch for Effective Management

Background: Smoking causes cancer, heart attacks, and stroke and leads to asthma and breathing problems. Nicotine replacement therapy (NRT) is considered one of the most widely accepted methods to quit smoking. However, it can lead to relapsed physical and psychological dependence. Aim: The present study aimed to explore propranolol, as a model drug to treat relapsed physical and psychological dependence due to NRT in smoking cessation. Furthermore, for its effective management, the transdermal drug delivery system has opted for the effective and long-term release of propranolol. Objective: The objective of the present study was to investigate and establish the molecular associations between propranolol with different targets associated with smoking cessation. Material and Methods: The molecular association of propranolol with eight different potential targets, namely, Acetylcholine Binding Protein (AChBP), Cannabinoid Receptor, CB1 and CB2, Monoamine oxidase (MAO), human dopamine D3 receptor, kainite, Leu- biogenic amine transporters (BAT) and α- type peroxisome proliferator-activated receptor, was studied via molecular simulation models. Polymeric films containing propranolol HCI were prepared and evaluated to select a suitable formulation for developing transdermal drug delivery systems (TDDS). Films containing different ratios of HPMC K4M, HPMC 15M, and Sodium CMC were prepared by the solvent evaporation technique using PEG 4000 incorporated as a plasticizer, and SLS was used to act as a penetration enhancer. Manufactured transdermal films were physically evaluated for thickness, weight uniformity %, moisture content %, moisture uptake %, drug content % and folding endurance. Results: Results indicated that propranolol can interact with all eight receptors at the active binding site. It was found to show considerable interaction with Acetylcholine Binding Protein (AChBP), MAO, human dopamine D3 receptor, kainite, and Leu- biogenic amine transporters (BAT) with the binding energy of -6.27, -6.74, -7.07, -6.84, and -6.63 kcal/mol, respectively. The release rate of propranolol HCI decreased linearly with increasing polymer concentration in the film and depended on the film thickness. In contrast, the quantity of drug release was proportional to the square root of time. Kinetic data based on the release exponent, ‘n’ in the Peppas model showed that n values were between 0.95 and 1.08, indicating that drug release from polymer matrix was predominantly by diffusion with swelling. Conclusion: Transdermal drug delivery of propranolol could act as a potential regulator of all studied targets associated with physical and psychological dependence associated with NRT and smoking cessation. Furthermore, propranolol-loaded transdermal patches with optimized release could be utilized to deliver the drug with optimum bioavailability for a considerable time.

Preparation and Evaluation of In-house Fabricated Floating Tablets of Black Pepper Extract

In folk medicine, Black pepper (Piper nigrum) has found its role as a hepato protective agent, diaphoretic, stomachic and for its aromatic properties. Ayurvedic medicine uses pepper extensively as bio-enhancer. It is known to have antioxidant, antiulcer activity and gastro protective effects. Helicobacter pylori is identified as gastric carcinogen and known to cause gastric cancer through injecting CagA, avirulent toxin, followed by its translocation intoVacA. The present study was designedfor development as well as evaluation of Pepper extract floating tablets for the management of peptic ulcers due by H. pylori. In the current experiment, we have developed gastro-retentive floating tablets of standardized pepper extract. Directly compressed were subjected to evaluation for various in vitro parameters. Floating tabletscontaining ingredients viz Pepper extract, HPMC K100Mhydrophilic polymer, colophony as hydrophobic polymer were used. Sodium bicarbonate was used to generate gas. Lubricants such as Talc and Magnesium stearate were used and to improve compressibility, Lactose was utilized. Directly compressed tablets were then subjected to evaluation. Formulations were optimized based on buoyancy time and considering drug release in vitro.The formulation 3 with the ingredients viz, pepper extract, lactose, HPMC K100M, sodium carbonate, talc, magnesium stearate and colophonyshowed good floating behavior along with improved controlled drug release in comparison with other formulations.We conclude that, the developed formulations can be effectively used to treat ulcers and in the prevention of gastric carcinogenesis.