Formulation and In-Vitro Evaluation of Amlodipine Besylate Floating Tablets Using Different Polymers

Abstract

Gastric-retentive amlodipine besylate effervescent tablets have been developed using a variety of hydrophilic polymers. Formulations were developed using different grades of different concentrations of polymer. H. HPMC K4M, HPMC K15M, HPMC K100 and xanthan gum were used as polymeric substances. The formulated mixtures have been subjected to various pre-formulation studies and flow properties, and all formulations show that the powder mixtures have good flow properties. Among all formulations, drug release was delayed for the desired period, H. 12 hours, for the HPMC K100 formulation as a polymer. The dissolution data showed that formulations made with HPMC K100M and xanthan gum as the polymer sustained drug release for the desired period. H. 12 hours at a concentration of 150 mg. On the other hand, in formulations containing HPMC K4M, HPMC K15M as polymer failed to produce the desired drug release. Therefore, the floating drug delivery system of amlodipine using the appropriate amount of appropriate polymer can increase the activity of the drug by prolonging the gastric residence time or decreasing the floating lag time. Keywords: Gastric-retentive, amlodipine besylate, effervescent tablets, HPMC K4M