Background: Learning by students is the cornerstone of the educational system, as well as the issues associated with this basic axis. One of the foundations of learning is the attendance of students in classes and attention to the instructions. Objectives: The present study aimed to discover the root causes of absenteeism among medical students at Guilan University of Medical Sciences (GUMS). Methods: This descriptive-analytical study was conducted on 127 basic science students at GUMS. Data were collected using a valid questionnaire consisting of 24 items to investigate the four components of the influential factors in absenteeism (S-CVI/Ave = 0.93; CVR ≥ 0.62; α = 91%). Data analysis was performed in SPSS version 21 using descriptive and analytical statistics at the significance level of P ≤ 0.05. Results: Among the four influential factors, professors’ performance (mean score: 18.26 ± 7.12) had the most significant effect and students' personal and family issues (mean score: 14.89 ± 6.76) had the least significant effect on absenteeism. In addition, significant correlations were observed between the status of medical sciences in the community with the variables of age, marital status, and housing occupancy status, as well as students' personal and family issues with marital status, professors' performance with the students' grade point average, and housing occupancy status and personal and family issues with professors' performance. Conclusions: Based on the results, it is recommended that educational planners and policymakers pay more attention to the factors mentioned by students as the most important causes of absenteeism, so that students would become more willing to attend educational environments and the teaching-learning process could be promoted.